DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl16 and Ecel1

DIOPT Version :9

Sequence 1:	NP_001097912.1	Gene:	Nepl16 / 43014	FlyBaseID:	FBgn0039277	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_068544.2	Gene:	Ecel1 / 60417	RGDID:	61806	Length:	775	Species:	Rattus norvegicus

Alignment Length:	740	Identity:	153/740 - (20%)
Similarity:	256/740 - (34%)	Gaps:	198/740 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 SAPPECSDPICEA-VASSIQARLNWNKDPCTEFKKFSC--W---RNTPNKNIT--NLIEMGNSQK 206
            :.|..|.:....| .|..:.|.|:.:.|||.:|..|:|  |   ...|:..:|  .:..:|..
  Rat    95 ACPEGCPERKAFARAARFLSANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAAIGEQ-- 157

  Fly   207 SVDSQMLYLFQNKIMNGSFGI----LHNLFESCLQ----QTTNSTVMHRIFDSLGG--------- 254
              :.:.|.....:...|..|.    :...|.|||.    :......|..:.:..||
  Rat   158 --NEERLRRLLARPTGGPGGAAQRKVRAFFRSCLDMREIERLGPRPMLEVIEDCGGWDLGGAADR 220

  Fly   255 ------------YLPVGSVGPSSIAPLIAKIYDLGPSPLVDLYHDLSYGRRPHILLIISGPSTSS 307
                        |...|....:::..|...:.|...|..| :..|......|...|.::....|.
  Rat   221 PGAARWDLNRLLYKAQGVYSAAALFSLTVSLDDRNSSRYV-IRIDQDGLTLPERTLYLAQDEESE 284

  Fly   308 TIL-------ERKIRWMSPKAPPSRIRQGVPKLLADLIENFLPYFVSYAQR-----VSEKDTIFE 360
            .:|       ||.:|.:.                ||.:|......:...||     |||.|
  Rat   285 KVLAAYKVFMERLLRLLG----------------ADAVEQKAQEILQLEQRLANISVSEYD---- 329

  Fly   361 FIKDLNKLQVEHSRRGFWDSTVLYN---VSSLQDLYPVLNWTLLIPQ------NWSGPIVVRNSD 416
               ||.:           |.:.:||   :..||.:.|.|.|..|:.|      :....:|:..:|
  Rat   330 ---DLRR-----------DVSSVYNKVTLGQLQKITPHLQWKWLLDQIFQEDFSEEEEVVLLATD 380

  Fly   417 YLKALEYFLTKYPTRVAHNSL-----LLLS---------ALQILPR-----DYPS--PEVCTRST 460
            |::.:...:...|.|:.||.|     ::||         ||..|.:     |.|.  ..||....
  Rat   381 YMQQVSQLIRSTPRRILHNYLVWRVVVVLSEHLSPPFREALHELAKEMEGNDKPQELARVCLGQA 445

  Fly   461 MWALPELSSSLYIAQHSSEDLKDTTKRAEIIFKSLKAHL-KRAPSL-------KGAALVKLSALK 517
            .........:|::.:|.|...|   .:.:.:.:.:|..| :|...|       |.||..||..:.
  Rat   446 NRHFGMALGALFVHEHFSAASK---AKVQQLVEDIKYILGQRLEELDWMDAQTKAAARAKLQYMM 507

  Fly   518 IQSQTWEGFSNTTDLLKSLQPLNITSECWFQNILEIYKKNKLEPNDISLNGG--------SHDAW 574
            :.    .|:   .|.|  |:|..:..|..|:...:.|.||.|.....|:...        ....|
  Rat   508 VM----VGY---PDFL--LKPEAVDKEYEFEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKSTW 563

  Fly   575 AYPIVS-TIFYDTLSHSIVVPLSVILIPYFNAVLPPYLHYASVGVSIAKEILRSITKSFDE---- 634
            ..|..: ..:|....:.:|.|..::....::...|..|:|..:|..|..|    :|..:|:
  Rat   564 LLPPQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHE----LTHGYDDWGGQ 624

  Fly   635 ---------------------KAMRCVPHSVNIFSNYSRM--------DILIHSGGMQISYHSML 670
                                 || .|:....:.|:.|::.        :.:...||::::|::..
  Rat   625 YDRSGNLLHWWTEASYSRFLHKA-ECIVRLYDNFTVYNQRVNGKHTLGENIADMGGLKLAYYAYQ 688

  Fly   671 SLT---GPIKGMARLPGLNLTPTQIFFLVSAQELC----AESNYLGI--DTNAPEFDNILGWLVA 726
            ...   ||...:.|   |..|..|:||:..||..|    ::|.||.:  |.:|||...:|| .|:
  Rat   689 KWVREHGPEHPLHR---LKYTHNQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLG-SVS 749

  Fly   727 QGGSATEVFKCPSGSMINVQKTCNV 751
            |.......|.||..|.:|....|:|
  Rat   750 QFEEFGRAFHCPKDSPMNPVHKCSV 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..749	CDD:301352	145/709 (20%)
Ecel1	NP_068544.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..51
Ecel1	NP_068544.2	M13	121..773	CDD:341056	145/711 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910