Protein Alignment Nepl16 and mmel1

DIOPT Version :10

• Sequence 1: NP_001097912.1
• Gene: Nepl16 / 43014
• FlyBaseID: FBgn0039277
• Length: 752
• Species: Drosophila melanogaster
• Sequence 2: XP_017213856.1
• Gene: mmel1 / 560703
• ZFINID: ZDB-GENE-101112-2
• Length: 765
• Species: Danio rerio
• Alignment Length: 800
• Identity: 176/800 - (22%)
• Similarity: 291/800 - (36%)
• Gaps: 196/800 - (24%)

  Fly    98 TSAAVHKMAITSATLLVTTLLVASPILFLISTAPSPLPRDCYMDGDRC------SPAVSAPPECS 156
            |....|:..:....|.|..||::..:..||....|.| |:.:...|..      |.|.|  ..|:
Zfish    15 TKPRKHRWTVVEIGLSVIVLLMSCALAGLIVLYTSAL-RERFNINDSSKGLKYRSDADS--NVCT 76

  Fly   157 DPICEAVASSIQARLNWNKDPCTEFKKFSC--WRNTPNKNITNLIEMGNSQKSV-----DSQMLY 214
            .|.|...|:.:...::.:.|||..|.:::|  |..      .::|...:|..||     |...:.
Zfish    77 TPQCVTAAARLLQNMDPSVDPCQNFYQYACGGWIE------RHVIPETSSLHSVFNILRDELEIV 135

  Fly   215 L-----FQNKIMNGSFGILHNLFESCLQ----QTTNSTVMHRIFDSLGGYLPVGSVGPSSIAPLI 270
            |     .:||....:|.....|:.||:.    :..:|..:.|:.||:|.:            |:.
Zfish   136 LKGVLEMENKDDREAFKKAKTLYSSCMNEILIEQRDSQPLLRLIDSIGDW------------PVA 188

  Fly   271 AKIYDLGPSPLVDLYHDLSYGRRPHILLIISGPSTSSTILERKIRWMSPKAPPSRI------RQG 329
            ::::: |.|.......|        .|.:::|......:||..: |...:.....|      ..|
Zfish   189 SEVWN-GTSEQTWSLED--------TLAVLNGRYNKKAVLEMFV-WPDDRDSSRYIIHVDQPALG 243

  Fly   330 VPK---LLAD-----LIENFLPYFVSYAQRVSEKD---------------TIFEFIKDLNKLQVE 371
            :|.   .|:|     :.|.:|.:.||.| |::.:|               .:.|...|:......
Zfish   244 MPSRDYYLSDGNYKKVREAYLEFMVSMA-RIAREDRNLTQDEERVLEDMSQVLELETDIANATSP 307

  Fly   372 HSRRGFWDSTVLYNVSSLQDLYPV-----LNWTLLIPQNWSG---------PIVVRNSDYLKALE 422
            ...|.  |.|||||..:|::....     .|||..|....|.         |||:..|.||:.|.
Zfish   308 AEERN--DITVLYNKMTLREAQQTFNLNGFNWTRYIQGIMSSVSISVQSDEPIVIYCSPYLEKLS 370

  Fly   423 YFLTKYPTRVAHNSL---LLLSALQILPRDYPSPEV------------------CTRSTMWALPE 466
            ..|:|:..|...|.|   |::..:..:.|.:.....                  |.|.....:..
Zfish   371 EVLSKHSHRTLQNYLVWMLIMDRVSSMSRRFKDVRAHYRKALHGTTVEEARWRDCVRYVQGNMEN 435

  Fly   467 LSSSLYIAQHSSEDLKDTTKR--AEIIFKSLKAHLKRAPSL-----KGAALVKLSALKIQSQTWE 524
            ...:||:    .|.....:||  .|:|.|..:|:::....|     :.....:..|:.|..|.
Zfish   436 AVGALYV----RETFSGNSKRMVGELIKKIQEAYVETLEELSWMDEQSKVKAREKAMAISEQI-- 494

  Fly   525 GF------SNTTDLLKSLQPLNITSECWFQNILEI--------YKKNKLEPNDISLNGGSHDAWA 575
            |:      .....|.:....||.:.|.:|:||||.        :||.: ||.|       .|.|.
Zfish   495 GYPDHILEEENKKLDQEYAHLNFSEENYFENILENLAASAQKGHKKLR-EPVD-------PDMWI 551

  Fly   576 Y-PIVSTIFYDTLSHSIVVPLSVILIPYFNAVLPPYLHYASVGVSIAKEILRSIT---KSFD--- 633
            . ..|...||....:.||.|..::..|:|:......|::..:|:.|..||.....   ::||
Zfish   552 IGAAVVNAFYSHNRNQIVFPAGILQPPFFSEKQLQALNFGGIGMVIGHEITHGFDDHGRNFDKDG 616

  Fly   634 --------------EKAMRCVPHSVNIFS-------NYSRMDIL----IHSGGMQISYHSMLSLT 673
                          |...:|:......||       |.|.:..|    ..:||::.:|.:.:...
Zfish   617 NMYNWWSNYSAERFEDQSKCMVEQYGRFSWKLAGGQNVSGITTLGENIADNGGVRQAYKAYVKWV 681

  Fly   674 GPIKGMARLPGLNLTPTQIFFLVSAQELC--AESNY----LGIDTNAPEFDNILGWLVAQGGSA- 731
            .......|||||::...|:|||..||..|  ....|    :..|.::|....:||.|  |...|
Zfish   682 EREGEEPRLPGLDMNHKQLFFLNFAQVWCGACRPEYAIQTIKTDPHSPLEYRVLGSL--QNFEAF 744

  Fly   732 TEVFKCPSGSMINVQKTCNV 751
            :|.|.|..|:.:|.::.|.|
Zfish   745 SEAFHCARGAPMNPEEKCRV 764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..750	CDD:472708	155/713 (22%)
mmel1	XP_017213856.1	M13	95..763	CDD:341056	155/714 (22%)