DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl16 and Nepl13

DIOPT Version :9

Sequence 1:	NP_001097912.1	Gene:	Nepl16 / 43014	FlyBaseID:	FBgn0039277	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster

Alignment Length:	739	Identity:	142/739 - (19%)
Similarity:	265/739 - (35%)	Gaps:	200/739 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 EAVASSIQARLNWNKDPCTEFKKFSC--WRNTPNKNITNLIEMGNSQKSVDSQMLYLFQNKIM-- 221
            :.:|:.:|..:|.:.||||:|.:::|  | ...:|......|:..:|:.:::::....|..:.
  Fly    54 QKIATDVQKYMNLSADPCTDFFEYACGQW-GRYHKRQLRPDELSTAQQLMETKISEQLQQLLTQP 117

  Fly   222 -------NGSFGI-------LHNLFESCLQQTTNSTVMHR----IFDSLGGYLPVGSVGPSS--- 265
                   ||..|.       :...:|||:....|::...|    |....||...|    |:|
  Fly   118 LPPQHHPNGYSGASMTNVRKVRAFYESCVAVEANASERRRFLMKILKDNGGLRNV----PNSNWQ 178

  Fly   266 -----IAPLIAKIYDLGPSPLVDLYHDLS---------YGRRPHILLIISGPSTSSTILERKIRW 316
                 :..|.....:.|...|:.|..||:         |...|.:.:|   |:.....|..:
  Fly   179 HNRQWVQTLGELRRNYGLDILLGLEIDLNLQTMKGNTIYFGEPKLTII---PAEHCNALATR--- 237

  Fly   317 MSPKAPPSRIRQGVPKLLADLI-ENFLPYF---VSYAQRVSEKDTI---FEFIKDLNKLQVEHSR 374
                  .:::|..|.:|:...: ||...:|   ...|.|.: .|.|   ||..|.:.:..::...
  Fly   238 ------GAQVRDEVYELVQQQVTENLRDWFGMDTGEAARFA-GDIIRFEFELCKQMGEQDIQKPE 295

  Fly   375 RGFWDS--TVLYNVSS-------------------LQDLYPVLNWTLLI----PQNWSGPIVVRN 414
            ..|..:  ..:|...|                   ..::...|::.:|:    ...:...:.:|:
  Fly   296 EEFPPAIQAQIYGARSRTGQERLRRQKGGMTLTELTSEMGNHLDFKMLVEVILESQYPSQVYLRS 360

  Fly   415 SDYLKALEYFLTKYPTRVAHNSLLLLSALQIL---PRDYPSPEV--CTRSTMWALPELSSSLYIA 474
            .:|:|.: ....|...|:.....:|..||..|   |.:.||...  |.:.|....|::...:: .
  Fly   361 PEYVKHV-VRTVKANNRITVGGYILYVALNELNQPPEEAPSQRARQCVQVTQRLFPQVLGEMF-Q 423

  Fly   475 QHSSED---------LKDTTKRAEIIFKSLKAHLK-RAPSLKGAALVKLSALKIQSQTWEGFSNT 529
            :|...|         ..|..|..|..|     |:: ...:.:.||..:||..::.
  Fly   424 RHVQRDNAKHDLDAVFNDVIKALEEQF-----HVEWMDENDRRAARTRLSQYRVS---------- 473

  Fly   530 TDLLKSLQPLNIT------SECWFQNILEI---YKKNK----LEPNDISLNGGSHDAWAYPIVST 581
               |...|.|::|      ||.:::. |||   |:.::    |..||...:....|  |:.:.:.
  Fly   474 ---LPDYQSLDLTDLQFQKSEDYWRR-LEIALKYRSHQQFEALRGNDFGQDADGLD--AFEVRAA 532

  Fly   582 IFYDTLSHSIVVPLSVILIPYFNAVLPPYLHYASVGVSIAKEILRS------------------I 628
            :  ......::|...::..||:|...|..|.||.:|..:|..::::                  :
  Fly   533 L--SPRQQMVLVGWGLLQAPYYNYYYPKSLKYALLGHRLASALVQAFDDEGWNNHPQATAQWNEV 595

  Fly   629 TKSFDEKAMRC--------VPHSVNIFSNYSRM-DILIHSGGMQISYHSMLS-------LTGPIK 677
            |.|....|..|        :.:....|.|.:|: :|:....|:.:::::.|:       ...|:.
  Fly   596 TMSGYRNASECQRAQYSSYLYNEPGEFRNATRLREIIADGSGLNLAFNAYLAWLEQQDHKLRPLL 660

  Fly   678 GMARLPGLNLTPTQIFFLVSAQELC-AESNYLGI--------------DTNAPEFDNILGWLVAQ 727
            ....|..||.|.||:||:..||..| |:.|...|              |.|.|         ::.
  Fly   661 AKETLSELNFTNTQLFFIYFAQTRCWAKDNQDAILDSMPLMQHTPERWDVNGP---------LSN 716

  Fly   728 GGSATEVFKCPSGSMINVQKTCNV 751
            .......|.|..|:.:|....|.|
  Fly   717 SAEFGREFGCALGTPMNSGDKCLV 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..749	CDD:301352	137/720 (19%)
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	137/720 (19%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	137/721 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910