DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl16 and Nep2

DIOPT Version :9

Sequence 1:	NP_001097912.1	Gene:	Nepl16 / 43014	FlyBaseID:	FBgn0039277	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster

Alignment Length:	824	Identity:	173/824 - (20%)
Similarity:	287/824 - (34%)	Gaps:	252/824 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 LVTTLLVASPILFLI-------------STAPSPLPRDCYMDGDRCSPAVSAPPE---------- 154
            |..:|||:..|:|::             .|:|...|:...:.||  |..::..|.
  Fly    17 LEKSLLVSLGIMFVVLATGFGLWIGKVLRTSPPSNPQATALHGD--STTINQVPTGTASKGKSGD 79

  Fly   155 ----CSDPICEAVASSIQARLNWNKDPCTEFKKFSCWRNTPNKNITNLIEMGNSQKSVDSQMLYL 215
                |....|...||::..::....:||..|.:|:|......:||.: .::..|..||.|..|..
  Fly    80 SGDVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPD-DKVSISTFSVISDKLQE 143

  Fly   216 FQNKIMNGS--------FGILHNLFESCLQQTTNSTV----MHRIFDSLGGYLPVGSVGPSSIAP 268
            ....|:...        |.:.:.|:::|:.:|...|:    :.|:.:.|||:            |
  Fly   144 QLKDIITAERPETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGW------------P 196

  Fly   269 LI-----------------AKIYDLGPSPLVDLYHDLSYG-------RRPHILLIISGPSTSSTI 309
            ||                 .|....|.|  :|...|.|.|       :|      :.....||..
  Fly   197 LIKGDSWNADDSWTWQEQVKKFRTAGFS--MDYIIDFSIGVDLQNSTKR------LIDLDQSSLA 253

  Fly   310 LERKIRWMSPKAPPSRIRQGVPKLLADLIENFLPYFVSYAQRVSEKDTIFEFIKDLNKLQV---- 370
            |.|:..              |......|:..:..|.|..|       .:|...:||.|.::
  Fly   254 LSREYL--------------VKGFNETLVTAYYKYMVDIA-------VLFGANRDLAKTELLLSL 297

  Fly   371 ------------EHSRRGFWDSTVLYNV---SSLQDLYPVLNW----TLLIPQ----------NW 406
                        ...||   :|:.|||:   :.||..||.:.|    ..|:|:          |.
  Fly   298 EFEMALANISWPNEKRR---NSSELYNLRTPAQLQAAYPYVQWVDYMNALLPEGLNVAEDEMINL 359

  Fly   407 SGPIVVRNSDYLKALEYFLTKYPTRVAHN---------------------SLLLLSALQILPRDY 450
            |.|      .:.:.|...|.|.|.||..|                     .|...:||.......
  Fly   360 SVP------SFFEDLGKLLAKTPKRVIANYMFWRIHGFSVGFLSEEFRKRQLQYATALSGRQEQE 418

  Fly   451 PSPEVCTRSTMWALPELS-----------SSLYIAQHSSEDLK----DTTKRAEIIFKSLKAHLK 500
            ...:.|......::.|:.           .|||:.:|..:|.|    :.......:|..:...:
  Fly   419 ARWKECVDIATSSMDEVCEDDFDSLGISVGSLYVGKHFHKDSKANALEMVNEIRNVFNDILDEV- 482

  Fly   501 RAPSLKGAALVKLSALKIQSQ-TWEGFS----NTTDLLKSLQPLNITSECWFQNILEI------Y 554
               :...|...|.:.||:.|. |..|:.    :...|......|:|..:.:|::.|.:      |
  Fly   483 ---NWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYYAKLDIDPDKYFESFLGMNIFGTDY 544

  Fly   555 KKNKLEPNDISLNGGSHDAWAYPIVSTIFYDTLSHSIVVPLSVILIPYFNAVLPPYLHYASVGVS 619
            ..|||.   :.:|.......|.|.:...||.:|.:||..|..::...:|||..|.|:::.::|..
  Fly   545 SFNKLR---LPVNKTDWVRHARPAIVNAFYSSLENSIQFPAGILQGHFFNAQRPKYMNFGAIGYV 606

  Fly   620 IAKEILRSIT---KSFDEKA-----------------MRCVPHSVNIFSNYSRM----------- 653
            |..||.....   :.||.|.                 .:|:   :..:.||:..
  Fly   607 IGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAKAKCI---IEQYGNYTERATGLNLNGINT 668

  Fly   654 --DILIHSGGMQ---ISYHSMLSLTGPIKGMARLPGLNLTPTQIFFLVSAQELCA----ESNYLG 709
              :.:..:||::   |:|.......||   .|:||||:.||.|:|::.:.|..||    ||..:.
  Fly   669 QGENIADNGGVKESYIAYRRWAEKHGP---EAKLPGLDYTPEQMFWVAAGQTWCAKYRKESLKMR 730

  Fly   710 IDT--NAPEFDNILGWLVAQGGSATEVFKCPSGSMINVQKTCNV 751
            |.|  ::|....:||.|......|.: |.||.||.:|..:.|.|
  Fly   731 ITTGVHSPSEFRVLGSLSNMKDFAKD-FHCPEGSPMNPVQKCEV 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..749	CDD:301352	154/730 (21%)
Nep2	NP_001246914.1	M13	104..772	CDD:189000	154/732 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910