DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl16 and KEL

DIOPT Version :9

Sequence 1:	NP_001097912.1	Gene:	Nepl16 / 43014	FlyBaseID:	FBgn0039277	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	XP_005250050.1	Gene:	KEL / 3792	HGNCID:	6308	Length:	744	Species:	Homo sapiens

Alignment Length:	783	Identity:	152/783 - (19%)
Similarity:	265/783 - (33%)	Gaps:	226/783 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 AVHKMAITSATLLVTTLLVASPILFLISTAPSPLPRDCYMDGDRCSPAVSAPPECSDPICEAVAS 165
            ||.:..:| |.|::..||..|.:||              .:...|.|.     .|...:|..:..
Human    55 AVARRVLT-AILILGLLLCFSVLLF--------------YNFQNCGPR-----PCETSVCLDLRD 99

  Fly   166 SIQARLNWNKDPCTEFKKFSCWR-----------NTPNKN-ITNLIEMGNS-QKSVDSQMLYLFQ 217
            ...|..|.:..|||:|..|:|.|           .|.||| :..::|:.|| ......:..:.|.
Human   100 HYLASGNTSVAPCTDFFSFACGRAKETNNSFQELATKNKNRLRRILEVQNSWHPGSGEEKAFQFY 164

  Fly   218 NKIMNGSFGILHNLFESCLQQTTNSTVMHRIFDSLGGYLPVG---SVGPSSIAPLIAKIYD---- 275
            |..|           ::...:...:..:.::.:.|||:...|   |:..:....|:...|.
Human   165 NSCM-----------DTLAIEAAGTGPLRQVIEELGGWRISGKWTSLNFNRTLRLLMSQYGHFPF 218

  Fly   276 ----LGPSPLVDLYHDLSYGRRPHILLIISGPSTSSTILERKIRWMSPKAPPSRIRQ---GVP-- 331
                |||.|                                    .||..|..:|.|   .||
Human   219 FRAYLGPHP------------------------------------ASPHTPVIQIDQPEFDVPLK 247

  Fly   332 -----KLLADLIENFLPYF----------VSYAQR-----VSEKDTIFEFIKDLNKLQVEHSRRG 376
                 |:.|.:...:|.|.          .|..|.     :|....:|:|::.|.:      ||.
Human   248 QDQEQKIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSSLSISITSRLFQFLRPLEQ------RRA 306

  Fly   377 FWDSTVLYNVSSLQDLYPVLNWTLLIPQNW-------SGPIVVRNSDYLKALEYFLTKYPTRVAH 434
            ......:..:..|:::.|.::|...:...:       |..:||.:.:|||
Human   307 QGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLK--------------- 356

  Fly   435 NSLLLLSALQILPRDYPSPEVCTRSTMWALPELSSSLYIAQHS-SEDLKDTTKRAEI-------- 490
            |...|:..:.:..||:....:.....:...|.|.|....|:.. |:.|::.|::..:
Human   357 NMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMK 421

  Fly   491 -------IFK-SLKAHLKR---APSLKGAALVKLSAL------KIQSQTW---EGFSNTTDLLKS 535
                   .|: :|.|...|   .||.:.||:...:|:      ::::..|   |..:...|.:..
Human   422 CVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQ 486

  Fly   536 LQPLNITSECWFQNILEIYKKNKLEPNDISLNGG-------------------------SHDAWA 575
            ||.....||...:..|.     :.|.|||.|...                         .|....
Human   487 LQVEMGASEWALKPELA-----RQEYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHPQHRWKV 546

  Fly   576 YPIVSTIFYDTLSHSIVVPLSVILIPYFNAVLPPYLHYASVGVSIAKEILRSITK--------SF 632
            .|.....:|....|.:|.|..::..|:|:...|..:::.:.|..:|.|:|....:        :.
Human   547 SPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCLAC 611

  Fly   633 DEKAMR----CVPHSVNIFSNYSR---------MDILIHSGGMQISYHSMLSLTGPIKGMARLPG 684
            |..|::    |:......|...||         ::.....||:.|:..:.........|...||.
Human   612 DNHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGETVLPS 676

  Fly   685 LNLTPTQIFFLVSAQELCAE-SNYLGIDTNAPEFDNILGWLVAQGGSATEVFKCPSGSMINVQKT 748
            |:|:|.||||...||.:|.: |.....||::|....:.|.|.:....| ..|:|..|:::|....
Human   677 LDLSPQQIFFRSYAQVMCRKPSPQDSHDTHSPPHLRVHGPLSSTPAFA-RYFRCARGALLNPSSR 740

  Fly   749 CNV 751
            |.:
Human   741 CQL 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..749	CDD:301352	135/704 (19%)
KEL	XP_005250050.1	PepO	106..744	CDD:226118	137/712 (19%)
KEL	XP_005250050.1	M13	109..742	CDD:189000	135/706 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910