DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl16 and Nepl10

DIOPT Version :9

Sequence 1:	NP_001097912.1	Gene:	Nepl16 / 43014	FlyBaseID:	FBgn0039277	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_610787.1	Gene:	Nepl10 / 36366	FlyBaseID:	FBgn0033742	Length:	633	Species:	Drosophila melanogaster

Alignment Length:	627	Identity:	119/627 - (18%)
Similarity:	227/627 - (36%)	Gaps:	129/627 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 CSPAVSAPPECSDPICEAVASSIQARLNWNKDPCTEFKKFSCWR-NTPNKNITNL--IEMGNSQK 206
            |..|:..|.:....|..|.::.|...||....|||.|..|:|.| ::.:|.:.|.  :|...:..
  Fly    10 CLVALFIPIQAIVDINVATSNDIHNNLNRTTSPCTNFWNFACGRFSSASKYVDNFERVEDQFATA 74

  Fly   207 SVDSQMLYLFQNKIMNGS-FGILHNLFESCLQQTTNSTVMHRIFDSLGGYLPVGSVGPSSIAPLI 270
            .|:....:|.:|..:... ...:...:::|.:.|..   :|      |...|...|....:.|..
  Fly    75 MVEFMESHLGENDTLAPRLIKQMRQYYKACKEDTRK---LH------GNPRPEELVNQWILHPKK 130

  Fly   271 AKIYDLGPSPLVDLYHDLSYGRRPHILLIISGPSTSSTILERKIRWMSPKAPPSRIRQGVPKLLA 335
            ..:|.|. ...:|...|::.......::.:..|..:....:|::..:......:....||.||:.
  Fly   131 FLVYGLN-GVFIDERVDVAANDSMRWVIQLRMPDPADRYSDRRVLQLMRLYEEAWYSMGVVKLVE 194

  Fly   336 DL--------IENFLPYFVSYAQRVSEKDTIFEFIKDLNKLQVEHSRRGFWDSTVLYNVSSLQDL 392
            .:        .|..:.|..|:::...|......|..:|  |.|.|:...:..:..:.:|..|::.
  Fly   195 KMHQLQDKYRAEYPVVYTWSFSELRQEIPIPHSFFIEL--LGVNHTEELYHLTFEVSDVEYLREC 257

  Fly   393 YPVLNWTLLIPQNWSGPIVVRNSDYLKALEYFLTKYPTRVAHNSLLLLSALQILPRDYPSPEVCT 457
            :..|......|::          .|::|.:|.|.:                :..||: .:|..|.
  Fly   258 FRCLRDFASEPKD----------TYIRARQYVLVE----------------ESEPRE-RNPRSCI 295

  Fly   458 RSTMWALPELSSSLY---IAQHSSEDLKDTTKRAEIIFKSLKA---------HLKRAPSLKGAAL 510
            ......||...:.:|   |.|:..|   ||:|..||: .:|||         .|:..|:......
  Fly   296 HHMRAYLPLGMNYIYDRFIYQNREE---DTSKVLEIL-STLKAAFGQYLDANRLQLTPNQLAYVR 356

  Fly   511 VKLSALKI------QSQTWEGFSNTTDLLKSLQPLNITSECWFQNILEIYK-KNKLEPNDISLNG 568
            .||..::|      :.::.|.::|      .....|.::..:..|:||.:. :.:|:...:....
  Fly   357 AKLEGIQIKIGNLPEEKSPEFYNN------HYGSANFSATNFLANLLEAFALRTRLQNAGLLARN 415

  Fly   569 GSHDAWAYPIVSTI-------FYDTLSHSIVVPLSVILIPYFN-------------AVLPPYLHY 613
            ...|...|.:...:       ||:...::|.||:..:..|.|:             |||...:::
  Fly   416 SRVDLRHYYVNDNVRKARTSPFYENERNTITVPMEFLQWPLFDHREHTIFQHSLLGAVLGHEMNH 480

  Fly   614 A---------------SVGVSIAKEILRSITKSFDEKAMRCVPHSVNIFSNYSRMDILIHSGGMQ 663
            |               .||:.|.:      :|.|.: |::|......:    |..:.|....|:|
  Fly   481 AFEQEGILFDAAGNESPVGLEIRE------SKPFRD-AIKCAEEQPFV----SLKERLADLNGLQ 534

  Fly   664 ISYHSMLSLTGPIKGMARLP---GLNLTPTQIFFLVSAQELC 702
            ::|.:...|....:.....|   ....|..|:|.|..||..|
  Fly   535 LAYDAFFGLAHDSRQFEYRPYAFEQEFTAPQLFHLSYAQFFC 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..749	CDD:301352	111/596 (19%)
Nepl10	NP_610787.1	GluZincin	41..608	CDD:301352	111/596 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910