DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl16 and Nep3

DIOPT Version :9

Sequence 1:	NP_001097912.1	Gene:	Nepl16 / 43014	FlyBaseID:	FBgn0039277	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_001245775.1	Gene:	Nep3 / 33005	FlyBaseID:	FBgn0031081	Length:	786	Species:	Drosophila melanogaster

Alignment Length:	811	Identity:	171/811 - (21%)
Similarity:	293/811 - (36%)	Gaps:	232/811 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 WLRTSAAVHKMAITSATLLVTTLLVASPILFLISTAP---------SPLPRDCYMDGDRCSPAVS 150
            ||..:..|  ||||..|||:        :||....:.         .|..:||        |:.:
  Fly    53 WLLITTFV--MAITIFTLLI--------VLFTDGGSSDATKHVLHVQPHQKDC--------PSGN 99

  Fly   151 APPECSDPICEAVASSIQARLNWNKDPCTEFKKFSC--W-RNTPNKNITNLIEMGNSQKSVDSQM 212
            ..| |.:..|...:|.|...::...|||.:|..:||  | :|.|
  Fly   100 ELP-CLNKHCIFASSEILKSIDVTVDPCDDFYGYSCNQWIKNNP--------------------- 142

  Fly   213 LYLFQNKIMNGSFGILHNLFESCLQQTTNSTVMHRIFDSLGGYLPVGSVGPSSIAPLIAKIY--- 274
              :.:.|...|:||.|..:         |..::..:.:.     |..|.  .|.|...||:|
  Fly   143 --IPEGKSTWGTFGKLEQM---------NQLIIRNVLEK-----PAKSF--KSDAERKAKVYYES 189

  Fly   275 ---------DLGPSPLVDLYHDLSYGRRPHILLIISGPSTSST--------------ILERKIR- 315
                     .||..|:.||            ||.|.|.:.:.:              ||..|..
  Fly   190 CLDADEHMEKLGAKPMNDL------------LLQIGGWNVTKSGYNVANWTMGHTLKILHNKYNF 242

  Fly   316 -----WMSPKAPPSRIRQ-------GVPKLLADLIEN-------FLPYFVSYAQRV------SEK 355
                 |...:...:..|.       |:....||...|       .|..::.|..:|      :|.
  Fly   243 NCLFGWAIGEDDKNSSRHVIQIDQGGLTLPTADYYNNKTDNHRKVLNEYIEYMTKVCVLLGANES 307

  Fly   356 DT------IFEFIKDLNKLQVE-HSRRGFWDSTVLYN---VSSLQDLYPVLNWT-------LLIP 403
            |.      :..|.|.|..:.:. ..||   :...:|:   :..|..|.|.||||       .::.
  Fly   308 DARAQMIGVINFEKKLANITIPLEDRR---NEEAMYHPMQLRQLSKLAPFLNWTDHFDNAMQMVG 369

  Fly   404 QNWSGP--IVVRNSDYLKALEYFLTKYPT----RVAHNSLLLLSALQILPRDYPSP-EVCTRSTM 461
            :..:..  :||...|:||.|...:.|...    ::..|:.|:..|::.|......| ....:...
  Fly   370 RRVTDDEVVVVYAPDFLKNLSDIILKMEQTEEGKITLNNYLVWQAVRTLTSCLSKPFRDAYKGVR 434

  Fly   462 WALPELSSSLYIAQHSSEDLKDTTKRA-EIIFKSLKAHLKRAPSLKG--AALVKLSALKIQSQTW 523
            .||........|.::...|..:....| ..||.....|.:..|:.:.  |.:.:...:.:|:.||
  Fly   435 KALMGSDGGEEIWRYCVSDTNNVVGFAVGAIFVRQAFHGESKPAAEQMIAEIREAFKMNLQNLTW 499

  Fly   524 ----------EGFSNTTDLL-------------KSLQPLNITSECWFQNILE--IYK-KNKLEPN 562
                      |..:..:|::             |....||||...:|:|.::  ||. |:.|:..
  Fly   500 VDKQTREKAIEKANQISDMIGFPDYILDPVELDKKYAELNITPNAYFENNIQVAIYNLKSNLKRL 564

  Fly   563 DISLNGGSHDAWAY-PIVSTIFYDTLSHSIVVPLSVILIPYFNAVLPPYLHYASVGVSIAKEILR 626
            |..:|..:   |.. |.....:|....:.||.|..::..|:|:...|..|::.::||.:..|:..
  Fly   565 DQPVNKTN---WGMTPQTVNAYYTPTKNQIVFPAGILQTPFFDINNPKSLNFGAMGVVMGHELTH 626

  Fly   627 SI------------------TKS---FDEKAMRCVPHSVNIFSNYSRM--------DILIHSGGM 662
            :.                  :||   |:||: .|:....:.:....|.        :.:..:||:
  Fly   627 AFDDQGREYDKFGNINRWWDSKSIERFNEKS-ECIARQYSGYKMNGRTLNGKQTLGENIADNGGL 690

  Fly   663 QISYHS-MLSLTGPIKGMARLPGLNLTPTQIFFLVSAQELCA----ESNYLGI--DTNAPEFDNI 720
            :.:||: ..:.:.....:.:|||||||.:|:||:..||..|:    |:|.|.:  |.::|....:
  Fly   691 KAAYHAYQRTKSDRDVDILKLPGLNLTHSQLFFVSFAQVWCSSTTDETNLLQMEKDPHSPSQFRV 755

  Fly   721 LGWLVAQGGSATEVFKCPSGSMINVQKTCNV 751
            :|.| :......|||:|..|..:|..:.|.|
  Fly   756 IGTL-SNMKEFAEVFQCKPGKRMNPTEKCEV 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..749	CDD:301352	148/717 (21%)
Nep3	NP_001245775.1	M13	123..784	CDD:189000	148/719 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910