DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl16 and Mmel1

DIOPT Version :9

Sequence 1:	NP_001097912.1	Gene:	Nepl16 / 43014	FlyBaseID:	FBgn0039277	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_001101467.2	Gene:	Mmel1 / 313755	RGDID:	1309299	Length:	774	Species:	Rattus norvegicus

Alignment Length:	852	Identity:	182/852 - (21%)
Similarity:	308/852 - (36%)	Gaps:	237/852 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 MGKSD-EIEMIDSANIENFNTRYNKNSIIGWICCAPCIWLRTSAAVHKMAITSATLLVTTLLVAS 121
            ||||: .:.|::.|  :|...|.     :|::.|...:.|              |||:...:|..
  Rat     1 MGKSESSVGMMERA--DNCGRRR-----LGFVECGLLVLL--------------TLLLMGAIVTL 44

  Fly   122 PILFLIS-----------------TAPSPLPRDCYMDGDRCSPAVSAPPECSDPICEAVASSIQA 169
            .:.:.|.                 |....:.||.....|          .|:.|.|...|:.|..
  Rat    45 GVFYSIGKQLPLLNSLLHVSRHERTVVKRVLRDSSQKSD----------ICTTPSCVIAAARILQ 99

  Fly   170 RLNWNKDPCTEFKKFSC--WRNTPNKNITNLIEMGNSQKSVDSQM---LYLFQNKIMNGSFGILH 229
            .::.:|.||..|.:::|  |..      .::|...||:.||...:   |.:....::..| .:.|
  Rat   100 NMDQSKKPCDNFYQYACGGWLR------HHVIPETNSRYSVFDILRDELEVILKGVLEDS-SVQH 157

  Fly   230 --------NLFESCLQQTT----NSTVMHRIFDSLGGYLPVG------SVGPS-----SIAPLIA 271
                    .|:.||:.|:.    :|..:..:.|.:||: ||.      ::||.     .:|.|.:
  Rat   158 RPAVEKAKTLYRSCMNQSVIEKRDSEPLLNVLDMIGGW-PVAMDKWNETMGPKWELERQLAVLNS 221

  Fly   272 KIYDLGPSPLVDLY---HDLSYGRRPHILLI----ISGPS-------TSSTILERKIRWMSPKAP 322
            :   .....|:||:   .|.:..|  |::.|    :..||       .|..:.|..:::|:..|.
  Rat   222 Q---FNRRVLIDLFIWNDDQNSSR--HVIYIDQPTLGMPSREYYFKEDSHRVREAYLQFMTSVAT 281

  Fly   323 PSRIRQGVPKLLADLIENFLPYFVSYAQRVSEKDTIFEFIKDLNKLQVEHSRRGFWDSTVLYNVS 387
            ..|....:|. ..||::             .|...:......|....|...:|  .|.|.||:..
  Rat   282 MLRRDLNLPG-ETDLVQ-------------EEMAQVLHLETHLANATVPQEKR--HDVTALYHRM 330

  Fly   388 SLQDL-----YPVLNWTLLIPQNWSG---------PIVVRNSDYLKALEYFLTKYPTRVAHNSL- 437
            .|::|     ....||||.|....|.         .:||....||:.||..:..:|.:...|.|
  Rat   331 GLEELQERFGLKGFNWTLFIQNVLSSVQVELLPNEEVVVYGIPYLENLEEIIDVFPAQTLQNYLV 395

  Fly   438 --LLLSALQILPRDYPSPEVCTRSTMWA------------------LPELSSSLYIAQHSSEDLK 482
              |:|..:..|.:.:....|..|..::.                  :.....||||.:..|:|.|
  Rat   396 WRLVLDRIGSLSQRFKEARVDYRKALYGTTMEEVRWRECVSYVNSNMESAVGSLYIKRAFSKDSK 460

  Fly   483 DTTKRAEIIFKSLKAHLKRAPSL-------KGAALVKLSALKIQSQTWEGF------SNTTDLLK 534
            ...  :|:|.|.....:.....|       |..|..|  ||.|:.|.  |:      .|...|.:
  Rat   461 SIV--SELIEKIRSVFVDNLDELNWMDEESKKKAQEK--ALNIREQI--GYPDYILEDNNRHLDE 519

  Fly   535 SLQPLNITSECWFQNILEIYKKN----------KLEPNDISLNGGSHDAWAY-PIVSTIFYDTLS 588
            ....|..:.:.:|:|.|:..|.|          |::.|          .|.. ..|...||....
  Rat   520 EYSSLTFSEDLYFENGLQNLKNNAQRSLKKLREKVDQN----------LWIIGAAVVNAFYSPNR 574

  Fly   589 HSIVVPLSVILIPYFNAVLPPYLHYASVGVSIAKEILRSIT---KSFDE---------------- 634
            :.||.|..::..|:|:...|..|::..:|:.|..||.....   ::||:
  Rat   575 NLIVFPAGILQPPFFSKDQPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMLDWWSNFSARHF 639

  Fly   635 -KAMRCVPHSVNIFS----------NYSRM-DILIHSGGMQISYHSMLSLTGPIKGMARLPGLNL 687
             :..:|:.:..:.||          .:|.: :.:..:||::.:|.:.|..........|||||||
  Rat   640 RQQSQCMIYQYSNFSWELADNQNVNGFSTLGENIADNGGVRQAYKAYLQWLAEGGRDQRLPGLNL 704

  Fly   688 TPTQIFFLVSAQELCAESNY--------LGIDTNAPEFDNILGWLVAQGGSATEVFKCPSGSMIN 744
            |..|:||:..||..|  .:|        :..|.::|....:||.|....| .:|.|.||.||.::
  Rat   705 TYAQLFFINYAQVWC--GSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLPG-FSEAFHCPRGSPMH 766

  Fly   745 VQKTCNV 751
            ....|.:
  Rat   767 PMNRCRI 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..749	CDD:301352	155/712 (22%)
Mmel1	NP_001101467.2	Stop-transfer sequence. /evidence=ECO:0000255	14..21		2/8 (25%)
Mmel1	NP_001101467.2	M13	106..772	CDD:341056	155/713 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910