DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl16 and Mmel1

DIOPT Version :9

Sequence 1:	NP_001097912.1	Gene:	Nepl16 / 43014	FlyBaseID:	FBgn0039277	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_038811.2	Gene:	Mmel1 / 27390	MGIID:	1351603	Length:	766	Species:	Mus musculus

Alignment Length:	743	Identity:	164/743 - (22%)
Similarity:	275/743 - (37%)	Gaps:	199/743 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 CSDPICEAVASSIQARLNWNKDPCTEFKKFSC--WRNTPNKNITNLIEMGNSQKSVDSQMLYLFQ 217
            |:.|.|...|:.|...::.:::||..|.:::|  |..      .::|...||:.||    ..:.:
Mouse    76 CTTPSCVIAAARILENMDQSRNPCENFYQYACGGWLR------HHVIPETNSRYSV----FDILR 130

  Fly   218 NKIMNGSFGILHN--------------LFESCLQQTT----NSTVMHRIFDSLGGYLPVG----- 259
            :::.....|:|.:              |:.||:.|:.    :|..:..:...:||: ||.
Mouse   131 DELEVILKGVLEDSTSQHRPAVEKAKTLYRSCMNQSVIEKRDSEPLLSVLKMVGGW-PVAMDKWN 194

  Fly   260 -SVG-----PSSIAPLIAKIYDLGPSPLVDLY---HDLSYGRRPHILLI----ISGPSTSSTILE 311
             ::|     ...:|.|.::   .....|:||:   .|.:..|  |::.|    :..||......|
Mouse   195 ETMGLKWELERQLAVLNSQ---FNRRVLIDLFIWNDDQNSSR--HVIYIDQPTLGMPSREYYFQE 254

  Fly   312 ---RKIR-----WMSPKAPPSRIRQGVPKLLADLIENFLPYFVSYAQRVSEKDTIFEFIKDLNKL 368
               .|:|     :|:..|...|..|.:.|..|.:.|              |...:.|....|...
Mouse   255 DNNHKVRKAYLEFMTSVATMLRKDQNLSKESAMVRE--------------EMAEVLELETHLANA 305

  Fly   369 QVEHSRRGFWDSTVLY---NVSSLQDLYPV--LNWTLLIPQNWSG---------PIVVRNSDYLK 419
            .|...:|  .|.|.||   ::..||:.:.:  .||||.|....|.         .:||....||:
Mouse   306 TVPQEKR--HDVTALYHRMDLMELQERFGLKGFNWTLFIQNVLSSVEVELFPDEEVVVYGIPYLE 368

  Fly   420 ALEYFLTKYPTRVAHNSL---LLLSALQILPRDYPSPEVCTRSTMWA------------------ 463
            .||..:..|..|...|.|   |:|..:..|.:.:....|..|..::.
Mouse   369 NLEDIIDSYSARTMQNYLVWRLVLDRIGSLSQRFKEARVDYRKALYGTTVEEVRWRECVSYVNSN 433

  Fly   464 LPELSSSLYIAQHSSEDLKDTTKRAEIIFKSLKAHLKRAPSL-------KGAALVKLSALKIQSQ 521
            :.....||||.:..|:|.|.|.:  |:|.|.....:.....|       |..|..|  |:.|:.|
Mouse   434 MESAVGSLYIKRAFSKDSKSTVR--ELIEKIRSVFVDNLDELNWMDEESKKKAQEK--AMNIREQ 494

  Fly   522 TWEGF------SNTTDLLKSLQPLNITSECWFQNILEIYKKN----------KLEPNDISLNGGS 570
            .  |:      .|...|.:....|....:.:|:|.|:..|.|          |::.|
Mouse   495 I--GYPDYILEDNNKHLDEEYSSLTFYEDLYFENGLQNLKNNAQRSLKKLREKVDQN-------- 549

  Fly   571 HDAWAY-PIVSTIFYDTLSHSIVVPLSVILIPYFNAVLPPYLHYASVGVSIAKEILRSIT---KS 631
              .|.. ..|...||....:.||.|..::..|:|:...|..|::..:|:.|..||.....   ::
Mouse   550 --LWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKDQPQSLNFGGIGMVIGHEITHGFDDNGRN 612

  Fly   632 FD-----------------EKAMRCVPH-------------SVNIFSNYSRMDILIHSGGMQISY 666
            ||                 ::..:|:.:             :||.||...  :.:..:||::.:|
Mouse   613 FDKNGNMLDWWSNFSARHFQQQSQCMIYQYGNFSWELADNQNVNGFSTLG--ENIADNGGVRQAY 675

  Fly   667 HSMLSLTGPIKGMARLPGLNLTPTQIFFLVSAQELCAESNY--------LGIDTNAPEFDNILGW 723
            .:.|..........||||||||..|:||:..||..|  .:|        :..|.::|....:||.
Mouse   676 KAYLRWLADGGKDQRLPGLNLTYAQLFFINYAQVWC--GSYRPEFAVQSIKTDVHSPLKYRVLGS 738

  Fly   724 LVAQGGSATEVFKCPSGSMINVQKTCNV 751
            |....| .:|.|.||.||.::..|.|.:
Mouse   739 LQNLPG-FSEAFHCPRGSPMHPMKRCRI 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..749	CDD:301352	158/718 (22%)
Mmel1	NP_038811.2	PepO	89..766	CDD:226118	159/730 (22%)
Mmel1	NP_038811.2	M13	97..764	CDD:189000	158/719 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010