DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl16 and Phex

DIOPT Version :9

Sequence 1:	NP_001097912.1	Gene:	Nepl16 / 43014	FlyBaseID:	FBgn0039277	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_037136.2	Gene:	Phex / 25512	RGDID:	3323	Length:	749	Species:	Rattus norvegicus

Alignment Length:	805	Identity:	152/805 - (18%)
Similarity:	278/805 - (34%)	Gaps:	229/805 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 LRTSAAVHKMAITSATLLVTTLLVASPILFLISTAPSPLPRDCYMDGDRCSPAVSAPPE-CSDPI 159
            :.|....::....:..|.:|..||...:|||:|..               ..:..|..| |..|.
  Rat     9 METGKGTNRGIRIALALFITGTLVLGTLLFLVSQG---------------LLSFQAKQEYCLKPE 58

  Fly   160 CEAVASSIQARLNWNKDPCTEFKKFSC--------------------W-RNTPNKNITNLIEMGN 203
            |...|::|.:::|.:.|||..|.:|:|                    | |:..:..:..|:|...
  Rat    59 CIEAAAAIMSKVNLSVDPCENFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKALLEKSV 123

  Fly   204 SQKSVDSQMLYLFQNKIMNGSFGILHNLFESCLQQTTNSTVMHRIFDSLGGYLPV--GSVGPSSI 266
            |::. |::.:.  :.||:..|.     :.|..:::.....::|.:..|...: ||  .::||..:
  Rat   124 SRRR-DTEAVQ--KAKILYSSC-----MNEKAIEKADAKPLLHILRHSPFRW-PVLEANIGPEGV 179

  Fly   267 APLIAKIYDLGPSPLVDLYHDLSYGRRPHILL----IISGPSTSSTILERKIRWMSPKAPPSR-- 325
                                   :..|...||    ...|..::|..:.   .::||....|.
  Rat   180 -----------------------WSERKFSLLQTLATFRGQYSNSVFIR---LYVSPDDKASNEH 218

  Fly   326 -IRQGVPKLLADLIENFLPYFVSYAQRVSEKDTIFEFIKD------LNKLQVEHSRRGFW----- 378
             ::.....|...:.|:||.   :..:..|.:|.:::|:.|      .|..:.||..:...
  Rat   219 ILKLDQATLSLAVREDFLD---NTTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIK 280

  Fly   379 -----------DSTVLY---NVSSLQDLYPVLNW---------TLLIPQ-NWSGP---IVVRNSD 416
                       .|..:|   |:|.|..:.|..:|         |.|.|. ...||   :|||...
  Rat   281 IAEIMIPHENRTSEAMYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDIGPSENVVVRVPQ 345

  Fly   417 YLKALEYFLTKYPTRVAHNSL---LLLSALQILPRDY------------------PSPEVCTRST 460
            |.|.|...|.....:...|.|   ::.|.:..|.|.:                  |..:.|....
  Rat   346 YFKDLFRILGAERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFI 410

  Fly   461 MWALPELSSSLYIAQHSSEDLKDTTKR---------AEIIFKS---LKAHLKRAPSLKG-AALVK 512
            ..|||.:...:::..|..||.|:..:.         .:::.|.   :.|..||....|. |.|.|
  Rat   411 ESALPYVVGKMFVNVHFQEDKKEMMEELIEGVRWAFIDMLEKENEWMDAGTKRKAQEKARAVLAK 475

  Fly   513 LSALKIQSQTWEGFSNTTDLLKSLQPLNITSECWFQNILEIYK---------KNKLEPNDISLNG 568
            :...       |...|.|.:.:.|:.:..:...:|.|:|:..|         ..|..|..
  Rat   476 VGYP-------EFIMNDTYVNEDLKAIKFSESDYFGNVLQTRKYLAQSDFFWLRKAVPKT----- 528

  Fly   569 GSHDAWAYPIVSTIFYDTLSHSIVVPLSVILIPYF-NAVLPPYLHYASVGVSIAKEILRSI---- 628
               :.:..|.....||...::.|..|...:..|:| ....|..|.|.::||.:..|.....
  Rat   529 ---EWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNG 590

  Fly   629 -----------------TKSFDEKAMRCVPHSVNIFSNY----SRMDI---------LIHSGGMQ 663
                             .:.|.||. :|:   :|.:|||    :.:::         :..:||::
  Rat   591 RKYDKNGNLDPWWSVDSEEKFKEKT-KCM---INQYSNYYWKKAGLNVKGKRTLGENIADNGGLR 651

  Fly   664 ISYHSMLS-LTGPIKGMAR--LPGLNLTPTQIFFLVSAQELC------AESNYLGIDTNAPEFDN 719
            .::.:... :....:|:..  |||:..|..|:|||..|...|      |....:.|..::|....
  Rat   652 EAFRAYRKWINDRRQGVEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFR 716

  Fly   720 ILGWLVAQGGSATEVFKCPSGSMIN 744
            :.| .::......:.|.||:.|.:|
  Rat   717 VNG-AISNFEEFQKAFNCPANSTMN 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..749	CDD:301352	135/724 (19%)
Phex	NP_037136.2	M13	74..740	CDD:341056	134/723 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910