DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl16 and Mme

DIOPT Version :9

Sequence 1:	NP_001097912.1	Gene:	Nepl16 / 43014	FlyBaseID:	FBgn0039277	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_036740.1	Gene:	Mme / 24590	RGDID:	3098	Length:	750	Species:	Rattus norvegicus

Alignment Length:	823	Identity:	164/823 - (19%)
Similarity:	276/823 - (33%)	Gaps:	276/823 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 MAITSATLLVTTLLVASPILFLISTAPSPLPRDCYMDGDRCSPAVSAPPECSDPICEAVASSIQA 169
            :.|:.:.|::...::|..::.|.:|         |.||           .|....|...|:.:..
  Rat    27 LEISLSVLVLLLTIIAVTMIALYAT---------YDDG-----------ICKSSDCIKSAARLIQ 71

  Fly   170 RLNWNKDPCTEFKKFSC--WRNTPNKNITNLIEMGNSQKSVDSQMLYLFQNKIMNGSFGILHN-- 230
            .::.:.:|||:|.|::|  |..      .|:|...:|:.|                :|.||.:
  Rat    72 NMDASAEPCTDFFKYACGGWLK------RNVIPETSSRYS----------------NFDILRDEL 114

  Fly   231 ------------------------LFESCLQQTTNSTVMHRIFDSLGGY-----------LPVGS 260
                                    |:.||:.::.        .||.||.           .||.|
  Rat   115 EVILKDVLQEPKTEDIVAVQKAKTLYRSCINESA--------IDSRGGQPLLTLLPDIYGWPVAS 171

  Fly   261 -----------VGPSSIAPLIAKIYDLGPSPLVDLYHDLSYGRRPHILLIISGPSTSSTILERKI 314
                       ....|||.|.:|                 ||::..|...:.....:||  :..|
  Rat   172 QNWEQTYGTSWTAEKSIAQLNSK-----------------YGKKVLINFFVGTDDKNST--QHII 217

  Fly   315 RWMSPK-APPSRIRQGVPKLLADLIENFLPYFVSYAQRVS--------------EKDTIFEFIKD 364
            .:..|: ..|||.......:..:....::.:.:|.|:.:.              |.:.:.|..|:
  Rat   218 HFDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKE 282

  Fly   365 LNKLQVEHSRRGFWDSTVLYNVSSLQDLYPVLNWTLLI---PQNWSG-----------------P 409
            :.....:...|.  |..:|||..:|..|..  |::|.|   |.:||.                 .
  Rat   283 IANATTKPEDRN--DPMLLYNKMTLAKLQN--NFSLEINGKPFSWSNFTNEIMSTVNINIQNEEE 343

  Fly   410 IVVRNSDYLKALEYFLTKYPTRVAHNSL---LLLSALQILPRDYPSPEVCTRSTMWALPELSSS- 470
            :||...:||..|:..||||..|...|.:   .::..:..|.|:|.......|..::.....:::
  Rat   344 VVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATW 408

  Fly   471 -----------------LYI-------AQHSSEDLKDTTKRAEIIFKSL------KAHLKRAPSL 505
                             ||:       ::|..|||  ..:..|:..::|      .|..|:....
  Rat   409 RRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDL--IAQIREVFIQTLDDLTWMDAETKKKAEE 471

  Fly   506 KGAALVKLSALKIQSQTWEGF-----SNTTDLLKSLQPLNITSECWFQNILEIYK-------KNK 558
            |        ||.|:.:.  |:     ||...|......||...|.:|:||::..|       |..
  Rat   472 K--------ALAIKERI--GYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKL 526

  Fly   559 LEPNDISLNGGSHDAW-AYPIVSTIFYDTLSHSIVVPLSVILIPYFNAVLPPYLHYASVGVSIAK 622
            .|..|       .|.| :...|...||.:..:.||.|..::..|:|:|.....|:|..:|:.|..
  Rat   527 REKVD-------KDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGH 584

  Fly   623 EILRSITKSFDEKAMR----------CVPHSVNIFSNYSRMDILIH-------SGGMQI------ 664
            |    ||..||:....          ....|.|.|.:.|:..:..:       :||..:
  Rat   585 E----ITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTL 645

  Fly   665 ---------------SYHSMLSLTGPIKGMARLPGLNLTPTQIFFLVSAQELCA------ESNYL 708
                           :|.:.:...|..|   .||||:|...|:|||..||..|.      ..|.:
  Rat   646 GENIADNGGIGQAYRAYQNYVKKNGEEK---LLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSI 707

  Fly   709 GIDTNAPEFDNILGWLVAQGGSATEVFKCPSGSMINVQKTCNV 751
            ..|.::|....|:|.| .......:.|.|...|.:|.::.|.|
  Rat   708 KTDVHSPGNFRIIGTL-QNSAEFADAFHCRKNSYMNPERKCRV 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..749	CDD:301352	151/748 (20%)
Mme	NP_036740.1	Stop-transfer sequence. /evidence=ECO:0000255	16..23
Mme	NP_036740.1	M13	79..748	CDD:341056	151/748 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010