Protein Alignment Nepl16 and ECE1

DIOPT Version :10

• Sequence 1: NP_001097912.1
• Gene: Nepl16 / 43014
• FlyBaseID: FBgn0039277
• Length: 752
• Species: Drosophila melanogaster
• Sequence 2: XP_011539174.1
• Gene: ECE1 / 1889
• HGNCID: 3146
• Length: 778
• Species: Homo sapiens
• Alignment Length: 869
• Identity: 172/869 - (19%)
• Similarity: 294/869 - (33%)
• Gaps: 280/869 - (32%)

  Fly    52 PVGSKQM-----GKSDEIEMIDSAN---------IENFNTRYNKNSIIGWICCAPCIWLRTSAAV 102
            |.||..|     ...||.:::||.:         ..||::..:     |..|.|    .||.  |
Human    20 PRGSNSMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRS-----GQRCWA----ARTQ--V 73

  Fly   103 HKMAITSATLLVTTLLVASPILFLISTAPSPLPRDCYMDGDRCSPAVS------APPECSDPICE 161
            .|..:....||...|:.                         |..|:.      :|..|....|.
Human    74 EKRLVVLVVLLAAGLVA-------------------------CLAALGIQYQTRSPSVCLSEACV 113

  Fly   162 AVASSIQARLNWNKDPCTEFKKFSC--WRNTPNKNITNLIEMGNSQKSVDSQMLYLFQNKIMNGS 224
            :|.|||.:.::...|||.:|..::|  |..      .|.:..|:|:
Human   114 SVTSSILSSMDPTVDPCHDFFSYACGGWIK------ANPVPDGHSR------------------- 153

  Fly   225 FGILHNLFESCLQQTTNSTVMHRIFDSLGGYLPVGSVGPSSIAPLIAKIY-----------DLGP 278
            :|...||:|.      |..::..:.::        |....|.|...|::|           :|..
Human   154 WGTFSNLWEH------NQAIIKHLLEN--------STASVSEAERKAQVYYRACMNETRIEELRA 204

  Fly   279 SPLVDLYHDLS-----------------------YGRRPHILLIISGPSTSSTILERKIRWMSPK 320
            .||::|...|.                       |...|...:.:|..|.:|.
Human   205 KPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSN------------ 257

  Fly   321 APPSRIRQ------GVP------------KLLADLIENFLPYFVSYAQRVSEKD---------TI 358
               |.:.|      |:|            |:|.    .:|.|.|...:.:...|         .|
Human   258 ---SNVIQVDQSGLGLPSRDYYLNKTENEKVLT----GYLNYMVQLGKLLGGGDEEAIRPQMQQI 315

  Fly   359 FEFIKDLNKLQVEHSRRGFWDSTVLYN---VSSLQDLYPVLNW-----TLLIPQ--NWSGPIVVR 413
            .:|...|..:.:...:|.  |..::|:   .:.||.|.|.:||     |:..|.  |.|.||||.
Human   316 LDFETALANITIPQEKRR--DEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVY 378

  Fly   414 NSDYLKALEYFLTKYPTRVAHNSL---LLLSALQILPRDY-------------------PSPEVC 456
            :.:||:.:...:......:.:|.:   |:......|.:.:                   |..:.|
Human   379 DKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFC 443

  Fly   457 TRSTMWALPELSSSLYIAQHSSEDLKDTTKRAEIIFKSLKAHLKRAPSLK-------GAALVKLS 514
            ...|...|......:::....:||.|...  .|||.:..||..:...:||       .:|..|..
Human   444 VSDTENNLGFALGPMFVKATFAEDSKSIA--TEIILEIKKAFEESLSTLKWMDEETRKSAKEKAD 506

  Fly   515 ALKIQSQTWEGFSN----TTDLLKSLQPLNITSECWFQNILEIYKKNKLEPNDISLNGGSHDAWA 575
            |:    ....|:.|    ..:|.|.........:.:|:|.:..:..:.....|......:.|.|:
Human   507 AI----YNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWS 567

  Fly   576 Y--PIVSTIFYDTLSHSIVVPLSVILIPYFNAVLPPYLHYASVGVSIAKEILRSITKSFDE---- 634
            .  |:|:. :|....:.||.|..::..|::....|..|::..:||.:..|    :|.:||:
Human   568 MTPPMVNA-YYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHE----LTHAFDDQGRE 627

  Fly   635 --------------------KAMRCVPHSVNIFSNYS--------RMDI---LIHSGGMQISYHS 668
                                :...|:   |..:||||        |..:   :..:||::.:|.:
Human   628 YDKDGNLRPWWKNSSVEAFKRQTECM---VEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRA 689

  Fly   669 MLSLTGPIKGMARLPGLNLTPTQIFFLVSAQELCA----ESNYLGI--DTNAPEFDNILGWLVAQ 727
            ..:..........||.|.||..|:|||..||..|:    ||::.|:  |.::|....::|.| :.
Human   690 YQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSL-SN 753

  Fly   728 GGSATEVFKCPSGSMINVQKTCNV 751
            ....:|.|:||.||.:|....|.|
Human   754 SKEFSEHFRCPPGSPMNPPHKCEV 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..750	CDD:472708	141/722 (20%)
ECE1	XP_011539174.1	M13	127..776	CDD:341056	141/723 (20%)