DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl16 and nep-2

DIOPT Version :9

Sequence 1:	NP_001097912.1	Gene:	Nepl16 / 43014	FlyBaseID:	FBgn0039277	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_494343.2	Gene:	nep-2 / 188090	WormBaseID:	WBGene00020230	Length:	736	Species:	Caenorhabditis elegans

Alignment Length:	783	Identity:	147/783 - (18%)
Similarity:	279/783 - (35%)	Gaps:	190/783 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 WLRTSAAVHKMAITSATLLVTTLLV-ASPILFLISTAPSPLPRDCYMDGDRCSPAVSAPPECSDP 158
            |.|.      .||.:..||:..||| .:.|.|.|:          |.|         :...|..|
Worm    17 WTRI------WAIIALILLILFLLVLGAAIYFYIN----------YKD---------SSDVCLSP 56

  Fly   159 ICEAVASSIQARLNWNKDPCTEFKKFSC--W-RNTP----NKNITNLIEMGNSQKSVDSQML--- 213
            .|...||.|.:.:|.:.|||.:|.:|:|  | :..|    ..:::|...:|...:....::|
Worm    57 GCIKTASVILSSMNSSVDPCDDFYEFACGQWIKGHPIPDDAPSVSNFENLGQDLEFALKELLDEN 121

  Fly   214 ---YLFQNKIMNGSFGILHNLFESCLQQT----TNSTVMHRIFDSLGGYLPVGSVGPSSIAPLIA 271
               |.::...: |.....:||   ||.::    ...|....:..|.||:..:|
Worm   122 DEPYDYETSAV-GKAKYFYNL---CLNESEILDNWRTTFDEVVKSFGGWPSLG------------ 170

  Fly   272 KIYDLGPSPLVD-LYHDL-----------------SYGRRPHILLIISGPSTSSTILERKIRWMS 318
              :.:.|...:: ||.|:                 ....:.|:|| |..|..:....:..:
Worm   171 --HQMKPDASIEMLYADMVAKFKADSLFKATVQPDDKNSQRHVLL-IDQPQLNLFARDFYV---- 228

  Fly   319 PKAPPSRIRQGVPKLLADLIENFLPYFVSYAQRVS---EKDTIFEFIKDLNKLQVEHSRRGFWDS 380
              |..:..|....:|:.|::      .:..|.|..   :...|.:|...|..:.:....|  .|.
Worm   229 --AAENEERMAYLQLIRDVL------ILLDADRTRATLDAKEIIDFETALANITMADEHR--HDI 283

  Fly   381 TVLYNVSSLQDL---YPVLNWTLLIPQNW---------------SGPIVVRNSDYLKALEYFLTK 427
            ..||...:|.::   .|..||.|...:.:               :..:||...::|:.|:..:.:
Worm   284 AELYTKITLGEMRRSLPHFNWPLFFNRMFKDLHEKNGKRITFDDNTEVVVYGYEFLRRLDVLIPQ 348

  Fly   428 YPTRVAHNSLLLLSALQILPRDYPSPEVCT-------------RSTMW---------ALPELSSS 470
            |..|:..|.|......:.:.||.|.|...|             :...|         .:|..:|:
Worm   349 YDNRLIVNYLEWCWFFKTMLRDLPDPFALTIFKFYKTLNIMNVQKVRWHGCVTRINSLMPMATSA 413

  Fly   471 LYIAQHSSEDLKDTTKR-AEIIFKSLKAHLKRAPSL----KGAALVKLSALKIQSQTWEGFSNTT 530
            :|:..|...:.|...:. ..:|.:|....|.....|    |..|..|::.:|.:....:..::..
Worm   414 IYVKNHFDHEAKQQVEEMISLIMESFVDLLLSEDWLTKETKQTAKQKVNEMKRKIGYPDYLNDPA 478

  Fly   531 DLLKSLQPLNITSECWFQNILEIYKKNKLEPNDISLNGGSHDAW-AYPIVSTIFYDTLSHSIVVP 594
            .:....:...:....::|.....|::.:.:..:........:.| |...:...||...::.|:.|
Worm   479 AVNNEYKTFKVYPGHYYQTKFSFYEQYQRDVLERITEAVDRERWVAGAALVNAFYSPNTNEIIFP 543

  Fly   595 LSVILIPYFNAVLPPYLHYASVGVSIAKEILR----------------------SITKSFDEKAM 637
            ..::...:::...|..:::..:||.|..||..                      :|:| |:.||
Worm   544 AGILQPVFYSKDFPSSMNFGGIGVVIGHEITHGFDDRGRLYDNLGNIRQWWDNATISK-FEHKA- 606

  Fly   638 RCVPHSVNIFSNY-------------SRMDILIHSGGMQISYHSMLSLTGPIKGMARLPGLNLTP 689
            :|:...   :|:|             ::.:.:..:||::.:|.:............||||:|||.
Worm   607 QCIEKQ---YSSYVLDQINMQINGKSTKGENIADNGGLKQAYRAYKKYEKRHSRPPRLPGVNLTH 668

  Fly   690 TQIFFLVSAQELCAESN------YLGIDTNAPEFDNILGWLVAQGGSATEVFKCPSGSMINVQKT 748
            .|:|||..||..|...|      .|....::|....:.|.| :......:.:.|..||.:|.::.
Worm   669 DQLFFLNYAQIWCGTMNDKEAIRKLRTSEHSPGPIRVKGPL-SNSYDFAKAYNCEPGSQMNPREK 732

  Fly   749 CNV 751
            |.|
Worm   733 CRV 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..749	CDD:301352	124/697 (18%)
nep-2	NP_494343.2	PepO	61..736	CDD:226118	130/714 (18%)
nep-2	NP_494343.2	M13	73..734	CDD:189000	124/699 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910