DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl16 and nep-18

DIOPT Version :9

Sequence 1:	NP_001097912.1	Gene:	Nepl16 / 43014	FlyBaseID:	FBgn0039277	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_494297.1	Gene:	nep-18 / 186911	WormBaseID:	WBGene00019343	Length:	701	Species:	Caenorhabditis elegans

Alignment Length:	758	Identity:	146/758 - (19%)
Similarity:	250/758 - (32%)	Gaps:	237/758 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 APPECSDPICEAVASSIQARLNWNKDPCTEFKKFSCWRNTPNKNITNLIEMGNSQKSVD-SQMLY 214
            :|..|....|..|.:.|:...|.:.|||.:|.:.:|.|.:.:      :...||...|. .|:||
Worm    23 SPETCWSKECVGVLAMIKNYQNASVDPCEDFFEHTCGRYSEH------VMDDNSWGYVQYKQLLY 81

  Fly   215 -LF-----QNKIMNGSFGILHNLFESCL--QQTTNSTV--MHRIFDSLGGYLPVGSVGPS----- 264
             :|     .||..:.....|....:|||  ::....|.  :....:..||: |:  :.|:
Worm    82 QVFAIARKTNKFNSKPNEQLRIFTKSCLDRKEMDEDTFQDLRNDIEERGGF-PM--IDPNWNEEK 143

  Fly   265 -SIAPLIAKIYDLGPSPL----VDLYHDLSYGRRPHILLIISGPSTSSTILERKIRWMSPKAPPS 324
             .::.::||...:..:.:    |:.|..:...:..:.|.:..||           .|:...|...
Worm   144 FDLSDMLAKYLSINRNRMGFLSVEPYAAIEGNKSVNRLYVSPGP-----------HWVYNWAMGI 197

  Fly   325 RI-RQGVPKLLADLIE------NFLPYFVSYAQRVSEKDTIFEFIKDLNKLQVEHSRRGFWDSTV 382
            .| :..|..:|..|::      |...|...:|:.| :.:..|..:.|...|.:::.     :.:.
Worm   198 SIYKDSVAFMLRRLLKLENRELNETIYDKEFAELV-QLEANFSTLADYRNLALDND-----NMSK 256

  Fly   383 LYNVSSLQDLYPVLNWTLLIPQNWSGPIVVRNSDYLKAL-----------------------EYF 424
            ..|::.|..:.|.::|..:                ||||                       |||
Worm   257 SRNLTDLVKMIPEIDWIKI----------------LKALARHGTSEEDEEKLLERVTVHGAGEYF 305

  Fly   425 L----------TKYPTRVAHNSL----LLLSALQILPRDYP----------SPEVCTRSTMWALP 465
            .          |:.|.....|.|    |:..||....:|.|          ....|........|
Worm   306 FGENRELARIATETPKSALANYLVVRQLIDVALYFYDKDQPRQNKFYNHVDQQSFCATQVASFFP 370

  Fly   466 ELSSSLYIAQHSSEDLKDTTKRAEIIFKSLKAHLKR--------APSLKGAALVKLSALKIQ--- 519
            ..|.:::|  .||:...:..|..|.:|..:||..::        ...::...:.||:|:..:
Worm   371 MPSMNVFI--ESSQFKIENLKVIEEMFVKIKAEYEQIFTENEYLELEIREFLIRKLNAIDGKFGL 433

  Fly   520 SQTWEG------FSNTTDLLKSLQPLNITSECW----FQNILEIYKKNKLEPNDISLNGGSHDAW 574
            .|..||      ...|.:.|.:..|..:..:.|    .|.:..|.....|:|.::.: .|:|.|:
Worm   434 DQYTEGKPLLEKMYETLNFLDTDSPWQVYMKMWRHWSEQLVEHIVHDTPLDPVNLKM-FGTHAAY 497

  Fly   575 -AYPIVSTIFYDTLSHSIVVPLSVILIPYFNAVLPPYLHYASVGVSIAKEI-------LRSITKS 631
             .||   ..||        :.|..:..|:.:|..|...:|..:|..|..||       .|.:.:|
Worm   498 QPYP---NHFY--------INLPYLTYPWMDADFPANTNYGYLGYVIGHEIGHAFDHFHRKLDES 551

  Fly   632 -------------------FDEKAMRCVPHSVNIFSNYSRMDILIHSGGMQISYHSMLSLTGPIK 677
                               ..||.:|      :.:|.|..........|.    |....:.|...
Worm   552 GRQQQYWFTETNSSNTEYELREKCLR------DQYSAYKEPGYDFFMNGT----HCRYEIAGDHM 606

  Fly   678 GMA---------------RLPGLNLTPTQIFFLVSAQELC-------AESNYL------------ 708
            |:.               |||||.::..|:||...|...|       ...|.|
Worm   607 GIRTAFRVFEKVKKEDRFRLPGLEMSEEQLFFYNYAFRQCDVYNPNKLPRNMLARQHPTNRYRVN 671

  Fly   709 GIDTNAPEFDNILGWLVAQGGSATEVFKCPSGSMINVQKTCNV 751
            |:..|.|||              .|.|.||..|.:|.:..|.:
Worm   672 GVIQNIPEF--------------AEAFNCPKNSPMNPEMKCKL 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..749	CDD:301352	139/729 (19%)
nep-18	NP_494297.1	PepO	42..692	CDD:226118	139/729 (19%)
nep-18	NP_494297.1	M13	47..699	CDD:189000	139/731 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910