Protein Alignment Nepl16 and Phex

DIOPT Version :9

• Sequence 1: NP_001097912.1
• Gene: Nepl16 / 43014
• FlyBaseID: FBgn0039277
• Length: 752
• Species: Drosophila melanogaster
• Sequence 2: NP_035207.1
• Gene: Phex / 18675
• MGIID: 107489
• Length: 749
• Species: Mus musculus
• Alignment Length: 808
• Identity: 150/808 - (18%)
• Similarity: 277/808 - (34%)
• Gaps: 235/808 - (29%)

  Fly    96 LRTSAAVHKMAITSATLLVTTLLVASPILFLISTAPSPLPRDCYMDGDRCSPAVSAPPE-CSDPI 159
            :.|....::....:..|.:...||...:|||:|..               ..:..|..| |..|.
Mouse     9 METGKGTNRGIRIALALFIGGTLVLGTLLFLVSQG---------------LLSFQAKQEYCLKPE 58

  Fly   160 CEAVASSIQARLNWNKDPCTEFKKFSC--------------------W-RNTPNKNITNLIEMGN 203
            |...|::|.:::|.:.|||..|.:|:|                    | |:..:..:..|:|...
Mouse    59 CIEAAAAIMSKVNLSVDPCENFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKALLEKSV 123

  Fly   204 SQKSVDSQMLYLFQNKIMNGSFGILHNLFESCLQQTTNSTVMHRIFDSLGGYLPV--GSVGPSSI 266
            |::. |::.:.  :.||:..|.     :.|..:::.....::|.:..|...: ||  .::||..:
Mouse   124 SRRR-DTEAVQ--KAKILYSSC-----MNEKAIEKADAKPLLHILRHSPFRW-PVLEANIGPEGV 179

  Fly   267 APLIAKIYDLGPSPLVDLYHDLSYGRRPHILL----IISGPSTSSTILERKIRWMSPKAPPSR-- 325
                                   :..|...||    ...|..::|..:.   .::||....|.
Mouse   180 -----------------------WSERKFSLLQTLATFRGQYSNSVFIR---LYVSPDDKASNEH 218

  Fly   326 -IRQGVPKLLADLIENFLPYFVSYAQRVSEKDTIFEFIKD------------------------- 364
             ::.....|...:.|:||.   :..:..|.:|.:::|:.|
Mouse   219 ILKLDQATLSLAVREDFLD---NTTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIK 280

  Fly   365 LNKLQVEHSRRGFWDSTVLY---NVSSLQDLYPVLNW---------TLLIPQ-NWSGP---IVVR 413
            :.::.:.|..|   .|..:|   |:|.|..:.|..:|         |.|.|. ...||   :|||
Mouse   281 IAEIMIPHENR---TSEAMYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDIGPSENVVVR 342

  Fly   414 NSDYLKALEYFLTKYPTRVAHNSL---LLLSALQILPRDY------------------PSPEVCT 457
            ...|.|.|...|.....:...|.|   ::.|.:..|.|.:                  |..:.|.
Mouse   343 VPQYFKDLFRILGAERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCV 407

  Fly   458 RSTMWALPELSSSLYIAQHSSEDLKDTTKR---------AEIIFKS---LKAHLKRAPSLKG-AA 509
            .....|||.:...:::..|..||.|:..:.         .:::.|.   :.|..||....|. |.
Mouse   408 NFIESALPYVVGKMFVNVHFQEDKKEMMEELIEGVRWAFIDMLEKENEWMDAGTKRKAQEKARAV 472

  Fly   510 LVKLSALKIQSQTWEGFSNTTDLLKSLQPLNITSECWFQNILEIYK---------KNKLEPNDIS 565
            |.|:...       |...|.|.:.:.|:.:..:...:|.|:|:..|         ..|..|..
Mouse   473 LAKVGYP-------EFIMNDTYVNEDLKAIKFSESDYFGNVLQTRKYLAQSDFFWLRKAVPKT-- 528

  Fly   566 LNGGSHDAWAYPIVSTIFYDTLSHSIVVPLSVILIPYF-NAVLPPYLHYASVGVSIAKEILRSI- 628
                  :.:..|.....||...::.|..|...:..|:| ....|..|.|.::||.:..|.....
Mouse   529 ------EWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFD 587

  Fly   629 --------------------TKSFDEKAMRCVPHSVNIFSNY----SRMDI---------LIHSG 660
                                .:.|.||. :|:   :|.:|||    :.:::         :..:|
Mouse   588 NNGRKYDKNGNLDPWWSVESEEKFKEKT-KCM---INQYSNYYWKKAGLNVKGKRTLGENIADNG 648

  Fly   661 GMQISYHSMLS-LTGPIKGMAR--LPGLNLTPTQIFFLVSAQELC------AESNYLGIDTNAPE 716
            |::.::.:... :....:|:..  |||:..|..|:|||..|...|      |....:.|..::|.
Mouse   649 GLREAFRAYRKWINDRRQGVEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPP 713

  Fly   717 FDNILGWLVAQGGSATEVFKCPSGSMIN 744
            ...:.| .::......:.|.||..|.:|
Mouse   714 QFRVNG-AISNFEEFQKAFNCPRNSTMN 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..749	CDD:301352	134/727 (18%)
Phex	NP_035207.1	PepO	67..741	CDD:226118	135/735 (18%)
		M13	74..747	CDD:189000	134/728 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000