Protein Alignment Nepl16 and nep-6

DIOPT Version :10

• Sequence 1: NP_001097912.1
• Gene: Nepl16 / 43014
• FlyBaseID: FBgn0039277
• Length: 752
• Species: Drosophila melanogaster
• Sequence 2: NP_494537.1
• Gene: nep-6 / 184628
• WormBaseID: WBGene00017550
• Length: 726
• Species: Caenorhabditis elegans
• Alignment Length: 826
• Identity: 152/826 - (18%)
• Similarity: 279/826 - (33%)
• Gaps: 276/826 - (33%)

  Fly   100 AAVHKMA---ITSATLLVTTL--LVASPILFLISTAPSPLPRDCYMDGDRCSPAVSAPPE----- 154
            :|..|:|   |.....||.|:  |:|:.|:..::..|...||...:.....:|...:.||
 Worm     2 SAKDKLANPLIALVVFLVLTIIALLATIIIMKLNEKPVEPPRVAPIAQKLVAPEKKSRPEPVTNP 66

  Fly   155 ------------------CSDPICEAVASSIQARLNW---NKDPCTEFKKFSCWRNTPNKNITNL 198
                              |..|.|..:|..:   ||:   :.|||.:|.|.:|.:.:.:
 Worm    67 VTMTRPEPVTQASKPRNVCETPGCVTLADQL---LNFQDPSVDPCQDFYKAACGKYSEH------ 122

  Fly   199 IEMGN---SQKSVDSQML---YLFQNKIMNG-SFGILHNLFESC-------LQQTTNSTVMHRIF 249
             |:.|   .:|.:..|.:   :|.:|:.... |..::..::.:|       :......|....:|
 Worm   123 -EVANRRLQKKDIIIQRMIKNFLLKNETSESKSENVMRQVYRTCEGLKNEEIFNANMKTAFRELF 186

  Fly   250 ---DSLGGY------------------LPVGSVGPSSIAPLIAKIYDLGPS--PLVDLYHDLSYG 291
               ..:|.:                  |.:..:|.|:..     ::.:.|:  |.:::..|::
 Worm   187 KDIQKIGSWPAADKNWDETKLNLNEMLLNIVKLGSSNFG-----LFQIRPTEVPFLEVAPDMA-- 244

  Fly   292 RRPHILLIISGPSTSST-------ILERKIRWMSPKAPPSRIRQGVPKLLADLIENFLPYFVSYA 349
                     ..|..|:.       |||:  ..:.|.          ..::||.:|::
 Worm   245 ---------RSPKVSANFQQIIFDILEK--NGLQPD----------ENVIADDVEDY-------- 280

  Fly   350 QRVSEKDTIFEFIKDLNKLQVEHSRRGFWDSTVLYNVSSLQDLYPVLNWTLLIPQNWSGPIVVRN 414
              ::.::|:.::..|.|..:|:.|:              ||...|.|....:|.:       :.|
 Worm   281 --ITLEETLSQYAYDYNAEKVQFSK--------------LQAQVPSLKLEKIIEE-------MMN 322

  Fly   415 SDYLKALEYFLTKY-PTRVAHNSLLLLSA---LQILPRDYPSPEV-------------------- 455
            .:..|.|   :||. |..|||...|....   |:.|.:..|...:
 Worm   323 PNRKKLL---VTKVKPRMVAHKHSLFFDEKMNLEKLLKSTPKRTLANYLIFYYMDHAMNGLSVHD 384

  Fly   456 -------CTRSTMWALPELSSSLYIAQHSSE-DLKDTTKRAEIIFKSLKAHLKRAPSLKGAALVK 512
                   |.:..:..||:.|..:::..|..: :||...:.||...||....|:.:..| ||...|
 Worm   385 NVIKKRNCEKLVIEYLPKASLRVFVRNHFEKGNLKIVDEMAEETKKSFIEMLQESTWL-GADSKK 448

  Fly   513 LSALKIQSQTW-----EGFSNTTDLLKSLQPLNITSECWFQNILEIYKKNKLE----------PN 562
            .:.||::....     :.|.....|.|..:.|.:..:.....||:...:..:|          |.
 Worm   449 NAILKLEKMGKMIGYPKEFEKKGALDKMFETLKLLPKDTLYGILKKIGRFHMEQGIEFVALETPM 513

  Fly   563 DISLNGGSHDAWAYPIVST-IFYDTLSHSIVVPLSVIL----IPYFNAVLPPYLHYASVGVSIAK 622
            |..|          |::.| .||...:|     ||.::    .|.|:|..|.|::.|..|..:|.
 Worm   514 DPVL----------PVLMTNAFYTDRNH-----LSFLVGYMDDPLFDATYPKYVNIALTGNILAH 563

  Fly   623 EI----------------LRSITKSFD----EKAMRCVPHSVNIFSNYSRMDILIHSGGMQISYH 667
            |.                :||..|..|    .|..:|:....|.:.:......|..:..:.....
 Worm   564 ETSHGFDTAGIKRDENGEVRSWMKPEDLKEYGKKTQCLVDQYNEYDDPVFGKNLNGTTTLNEMVA 628

  Fly   668 SMLSLTGPIKGMARLPGL---------NLTPTQIFFLVSAQELCA----------------ESNY 707
            .|:.:|...|...:|...         |....:::|..:|.:.|:                ..|:
 Worm   629 DMIGVTVAWKVFEKLDSSKEQKVIGFENENIDKLYFRAAALDFCSLPPTTSLVEELTRVHPTGNF 693

  Fly   708 L--GIDTNAPEFDNILGWLVAQGGSATEVFKCPSGSMINVQKTCNV 751
            .  ||.:|.|:|             || .|.||.||.:|.:..|::
 Worm   694 RVNGIFSNMPQF-------------AT-AFNCPEGSPMNPKTRCSI 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..750	CDD:472708	129/716 (18%)
nep-6	NP_494537.1	M13	105..724	CDD:341056	129/717 (18%)