DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl16 and nep-6

DIOPT Version :9

Sequence 1:	NP_001097912.1	Gene:	Nepl16 / 43014	FlyBaseID:	FBgn0039277	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_494537.1	Gene:	nep-6 / 184628	WormBaseID:	WBGene00017550	Length:	726	Species:	Caenorhabditis elegans

Alignment Length:	826	Identity:	152/826 - (18%)
Similarity:	279/826 - (33%)	Gaps:	276/826 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 AAVHKMA---ITSATLLVTTL--LVASPILFLISTAPSPLPRDCYMDGDRCSPAVSAPPE----- 154
            :|..|:|   |.....||.|:  |:|:.|:..::..|...||...:.....:|...:.||
Worm     2 SAKDKLANPLIALVVFLVLTIIALLATIIIMKLNEKPVEPPRVAPIAQKLVAPEKKSRPEPVTNP 66

  Fly   155 ------------------CSDPICEAVASSIQARLNW---NKDPCTEFKKFSCWRNTPNKNITNL 198
                              |..|.|..:|..:   ||:   :.|||.:|.|.:|.:.:.:
Worm    67 VTMTRPEPVTQASKPRNVCETPGCVTLADQL---LNFQDPSVDPCQDFYKAACGKYSEH------ 122

  Fly   199 IEMGN---SQKSVDSQML---YLFQNKIMNG-SFGILHNLFESC-------LQQTTNSTVMHRIF 249
             |:.|   .:|.:..|.:   :|.:|:.... |..::..::.:|       :......|....:|
Worm   123 -EVANRRLQKKDIIIQRMIKNFLLKNETSESKSENVMRQVYRTCEGLKNEEIFNANMKTAFRELF 186

  Fly   250 ---DSLGGY------------------LPVGSVGPSSIAPLIAKIYDLGPS--PLVDLYHDLSYG 291
               ..:|.:                  |.:..:|.|:..     ::.:.|:  |.:::..|::
Worm   187 KDIQKIGSWPAADKNWDETKLNLNEMLLNIVKLGSSNFG-----LFQIRPTEVPFLEVAPDMA-- 244

  Fly   292 RRPHILLIISGPSTSST-------ILERKIRWMSPKAPPSRIRQGVPKLLADLIENFLPYFVSYA 349
                     ..|..|:.       |||:  ..:.|.          ..::||.:|::
Worm   245 ---------RSPKVSANFQQIIFDILEK--NGLQPD----------ENVIADDVEDY-------- 280

  Fly   350 QRVSEKDTIFEFIKDLNKLQVEHSRRGFWDSTVLYNVSSLQDLYPVLNWTLLIPQNWSGPIVVRN 414
              ::.::|:.::..|.|..:|:.|:              ||...|.|....:|.:       :.|
Worm   281 --ITLEETLSQYAYDYNAEKVQFSK--------------LQAQVPSLKLEKIIEE-------MMN 322

  Fly   415 SDYLKALEYFLTKY-PTRVAHNSLLLLSA---LQILPRDYPSPEV-------------------- 455
            .:..|.|   :||. |..|||...|....   |:.|.:..|...:
Worm   323 PNRKKLL---VTKVKPRMVAHKHSLFFDEKMNLEKLLKSTPKRTLANYLIFYYMDHAMNGLSVHD 384

  Fly   456 -------CTRSTMWALPELSSSLYIAQHSSE-DLKDTTKRAEIIFKSLKAHLKRAPSLKGAALVK 512
                   |.:..:..||:.|..:::..|..: :||...:.||...||....|:.:..| ||...|
Worm   385 NVIKKRNCEKLVIEYLPKASLRVFVRNHFEKGNLKIVDEMAEETKKSFIEMLQESTWL-GADSKK 448

  Fly   513 LSALKIQSQTW-----EGFSNTTDLLKSLQPLNITSECWFQNILEIYKKNKLE----------PN 562
            .:.||::....     :.|.....|.|..:.|.:..:.....||:...:..:|          |.
Worm   449 NAILKLEKMGKMIGYPKEFEKKGALDKMFETLKLLPKDTLYGILKKIGRFHMEQGIEFVALETPM 513

  Fly   563 DISLNGGSHDAWAYPIVST-IFYDTLSHSIVVPLSVIL----IPYFNAVLPPYLHYASVGVSIAK 622
            |..|          |::.| .||...:|     ||.::    .|.|:|..|.|::.|..|..:|.
Worm   514 DPVL----------PVLMTNAFYTDRNH-----LSFLVGYMDDPLFDATYPKYVNIALTGNILAH 563

  Fly   623 EI----------------LRSITKSFD----EKAMRCVPHSVNIFSNYSRMDILIHSGGMQISYH 667
            |.                :||..|..|    .|..:|:....|.:.:......|..:..:.....
Worm   564 ETSHGFDTAGIKRDENGEVRSWMKPEDLKEYGKKTQCLVDQYNEYDDPVFGKNLNGTTTLNEMVA 628

  Fly   668 SMLSLTGPIKGMARLPGL---------NLTPTQIFFLVSAQELCA----------------ESNY 707
            .|:.:|...|...:|...         |....:::|..:|.:.|:                ..|:
Worm   629 DMIGVTVAWKVFEKLDSSKEQKVIGFENENIDKLYFRAAALDFCSLPPTTSLVEELTRVHPTGNF 693

  Fly   708 L--GIDTNAPEFDNILGWLVAQGGSATEVFKCPSGSMINVQKTCNV 751
            .  ||.:|.|:|             || .|.||.||.:|.:..|::
Worm   694 RVNGIFSNMPQF-------------AT-AFNCPEGSPMNPKTRCSI 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..749	CDD:301352	129/715 (18%)
nep-6	NP_494537.1	M13	105..724	CDD:189000	129/717 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910