Protein Alignment Nepl16 and nep-17

DIOPT Version :10

• Sequence 1: NP_001097912.1
• Gene: Nepl16 / 43014
• FlyBaseID: FBgn0039277
• Length: 752
• Species: Drosophila melanogaster
• Sequence 2: NP_001254395.1
• Gene: nep-17 / 174996
• WormBaseID: WBGene00010070
• Length: 1589
• Species: Caenorhabditis elegans
• Alignment Length: 874
• Identity: 179/874 - (20%)
• Similarity: 286/874 - (32%)
• Gaps: 296/874 - (33%)

  Fly   104 KMAITSATLLVTTLL-VASP----ILFLISTAPS-----PLPRDCYMDGDRCSPAVS-------- 150
            :|..|.|..|...|: |.||    :|..|...|:     ..|...|...:.|:..||
 Worm   779 QMPYTDAQFLRQILVDVHSPSIYRVLGTIQNFPAFKTAFNCPSSTYAPDNHCNVWVSDIDTTFGL 843

  Fly   151 --------APPECSDPICEAVASSIQA----------RLNWNKDPCTEFKKFSCWRNTPNKNITN 197
                    ..||.  ||.......:.|          .:|...|||.:|..::|
 Worm   844 PNVKTDINVVPEA--PITSTNVDKMNAYQMAVDYYAKSVNTAIDPCDDFYSYAC----------- 895

  Fly   198 LIEMGNSQKSVD-----SQMLYLFQNKIMNGSFGILHN----------LFESCLQQTTNS----- 242
                ||..:||.     :|.|.....|:.:.::....|          |:.:||..|.:|
 Worm   896 ----GNFNQSVSFYTARAQNLVYMAQKLEDPTYQTTINSSPALKKEKQLYNACLTATASSQSEDQ 956

  Fly   243 ----------------TVMHRIFDSLGGYLP-------VG-SVGPSSIAPLIAKIYDLGPSPLVD 283
                            |::.:.|..:.|..|       :| ::|..|....|    |...|||||
 Worm   957 ILISKNYIQTKVDDLKTLIGQDFTLVNGGAPKLPSAKQIGDALGYLSFEQGI----DTLISPLVD 1017

  Fly   284 LYH-DLSYGRRPHILLIISGPSTSSTILERKIRWMSPKAPPSRIRQG--------------VPKL 333
            .|. |.|.|   :.:.|....:..|....:...|...|  |..::..              :|..
 Worm  1018 TYWIDNSKG---YQMFIDQNTAYLSKTYYQPAAWKIEK--PKYLKMALDVVTRYAREQNITLPAG 1077

  Fly   334 LADLIENFLPYFVSYAQRVSEKDTIFEFIKDLNKLQVEHSRRGFWDSTVLYNVSSLQDLYPVLNW 398
            .:||:.|.|.|..:.|.:.|..|               ::||.|..|..|...|.|...|..::|
 Worm  1078 ASDLLSNVLDYEQNIAVKYSTDD---------------NTRRQFQRSWNLTKTSDLVTKYNFMDW 1127

  Fly   399 TLLIPQNWSGPIVVR---------------------NSDYLK----------------ALEYFLT 426
            ...:..   .|..|:                     ::|||:                ....::.
 Worm  1128 MTYLSH---APNAVKAKITDANYQVSVMEVDRLTHFSADYLQQSPELLVNLLFVRLLLGNAQYIP 1189

  Fly   427 KYPTR---VAHNSLLL-LSALQILPRDYPSPEVCTRSTMWALPELSSSL-----------YIAQH 476
            .|.:.   :...|:.| ||..:.:|...|.|.....:...|...::::|           |: ..
 Worm  1190 SYASAFRGMTDESIFLGLSRRKTIPNHIPPPNFDLEANGPACASVANNLMQFANGRVFVDYM-YP 1253

  Fly   477 SSEDLKDTTKRAEIIFKSLKAHLK--------RAPSLKGAALVKLSALKIQSQ----TWEGFSNT 529
            :::|:.:..|.|..|.|::.:..:        .||..|..|..|  .::||..    .|  ..|.
 Worm  1254 TAQDVTNIRKSAGGIIKNVISSFQGMIDQLDWMAPDTKQKAYAK--TVQIQQNIAFPDW--IKND 1314

  Fly   530 TDLLKSLQPLNITSECWFQNILEIYKK----------NKL-----EPNDISLNGGSHDAWAYPIV 579
            |.|......|.|...   .|..:||.|          |:|     :..|.....|:.:||..|.:
 Worm  1315 TLLGNYYSTLVIADS---DNFYDIYDKLIKFNIFVQYNQLNAAQTDRTDFLGQPGTVNAWYQPEL 1376

  Fly   580 STIFYDTLSHSIVVPLSVILIPYFNAVLPPYLHYASVGVSIAKEILRSITKSFDEKAMRCVP--- 641
                     :||..|..:::.||||...||.::|..:|:....|    :|..||::.::..|
 Worm  1377 ---------NSITFPAGILVPPYFNPNWPPSINYGGMGLVAGHE----LTHGFDDQGVQWGPTGN 1428

  Fly   642 -------HSVNIFSNYSRMDILIHSG--------------------GMQI-----------SYHS 668
                   :|:..|.|.|:..|..:||                    |..|           :|.:
 Worm  1429 LARWMDDNSMAGFKNMSQCVINEYSGFCPLNATNYSPNCVKGPQTQGENIADNGGVHAAFNAYKT 1493

  Fly   669 MLSLTGPIKGMARLPGL---NLTPTQIFFLVSAQELC-------AESNYLGIDTNAPEFDNILGW 723
            ..||.||   ..|||..   ..|..|:||:..||..|       |....:.:|.::|....:.|.
 Worm  1494 HQSLDGP---DPRLPDRLFGQFTHDQLFFMSFAQVWCEVRRTDDALYTQIMVDPHSPSMYRVYGT 1555

  Fly   724 LVAQGGSATE-VFKCPSGSMINVQKTCNV 751
            :  |...|.: .|.||.||....::.|.|
 Worm  1556 I--QNFPAFQTAFNCPLGSKSAPEQHCEV 1582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..750	CDD:472708	155/763 (20%)
nep-17	NP_001254395.1	M13	112..831	CDD:341056	13/51 (25%)
		M13	884..1581	CDD:341056	155/764 (20%)