Protein Alignment Nepl16 and nep-1

DIOPT Version :10

• Sequence 1: NP_001097912.1
• Gene: Nepl16 / 43014
• FlyBaseID: FBgn0039277
• Length: 752
• Species: Drosophila melanogaster
• Sequence 2: NP_496490.2
• Gene: nep-1 / 174787
• WormBaseID: WBGene00013926
• Length: 754
• Species: Caenorhabditis elegans
• Alignment Length: 802
• Identity: 172/802 - (21%)
• Similarity: 298/802 - (37%)
• Gaps: 228/802 - (28%)

  Fly   122 PILFLIST-------APSPLPRDCYMDGD-RCSPAVSAPPECSDPICE------AVASS------ 166
            ||:||||.       ....|||..|.:.| ..:...|......:.:.|      .|..|
 Worm     8 PIVFLISCYALILCGTVDALPRAPYFNDDINKTTTTSEDKTVGNTVVEEEKKTYTVGDSEGYQEA 72

  Fly   167 ---IQARLNWNKDPCTEFKKFSC--WRNT---PNKNITNLIEMGNSQKSVDSQMLYLFQNKI--- 220
               :|..||.:.|||.:|.:::|  |.::   |: ::|:..:...:::.|.::|..|:::..
 Worm    73 SRLLQKSLNLSLDPCDDFFEYACRAWVDSHPIPD-DLTSYSQFTATREKVLAEMRKLYEDNTSIP 136

  Fly   221 MNGSFGILHNLFESCLQQTTNSTVMHR-IFDSLG--GYLPV--GSVGPSSIAPL----------- 269
            .:.|..::..::.:|:....::.|..| :.:.:.  ||.|:  ......|...|
 Worm   137 TSKSIALIKQIYNTCMDTEKHNAVGARDLLEKIKTYGYWPMVHNEKWRESTFDLTKLLSNTIQSR 201

  Fly   270 -IAKIYDLGPSPLVDLYHDLSYGRRPHILLIIS------GPSTSSTILERKIRWMSPKA----PP 323
             ::..:|.||:.     ...:..||   ||...      |.||....|:.|......||    ..
 Worm   202 DVSVFFDFGPAE-----DSRNVSRR---LLSFDQGSLGLGYSTRDYYLDEKKYEKQMKAYRKYTI 258

  Fly   324 SRIRQGVPKLLADLIENFLPYF-------VSYAQRVSEKDTIFEFIKDLNKLQV-EHSRRGFWDS 380
            .::|                |:       |:.::..|:.|.|..|.|:..::.| |..||.:
 Worm   259 GKVR----------------YYTEDAGMAVNESKIESDVDEIIAFEKEWAQILVAEEDRRNY--- 304

  Fly   381 TVLYNVSSLQDL---YPVLNWTLL------------IPQNWSGPIVVRNSDYLKALEYFLTKYPT 430
            |.||||....||   ..:::|..|            :..|.|  |::.:.:||:.:...|.....
 Worm   305 TKLYNVRRFDDLKEYMSIIDWKKLTLSTTPFLVHSYLKTNPS--IIISDVEYLQKMNTLLQNTDP 367

  Fly   431 RVAHNSLLLL-------------------SALQILPRDYPSP--EVCTRSTMWALPELSSSLYIA 474
            |:..|.:||.                   .|.|:..|....|  :.|..|....|...|.|:|:.
 Worm   368 RIVTNYILLRWAGSWSQEIGKKYEDLQQEFAFQMYGRKQRQPRWKDCVSSAGGKLSYASGSMYVR 432

  Fly   475 QHSSEDLKDTTKRAEII------FKS-------LKAHLKRAPSLKGAALVK--------LSALKI 518
            ::...:.|:||  .::|      |::       :.|..|:....|...::|        |:..|:
 Worm   433 KYFDANAKNTT--LDMITDLQEAFRNMMHANDWMDAETKKYALEKADQMLKQIGYPDFILNDEKL 495

  Fly   519 QSQTW---------EGFSNTTDLLKSLQPLNITSECWFQNILEIYKKNKLEP-NDISLNGGSHDA 573
            ..  |         :.||...:  ||:|        |..|   .|.:..||| |.......:
 Worm   496 DD--WYKGLEGAPEDSFSQLVE--KSIQ--------WRNN---FYYRRLLEPVNRFEFISSA--- 542

  Fly   574 WAYPIVSTIFYDTLSHSIVVPLSVILIPYFNAVLPPYLHYASVGVSIAKEI-------------- 624
                .|...||....::|..|..::..|:|:|..|..|:|..:|..|..||
 Worm   543 ----AVVNAFYSPTRNAIAFPAGILQQPFFDARFPKALNYGGIGAVIGHEITHGFDDTGRQFDNV 603

  Fly   625 --LR-----SITKSFDEKAMRCVPH----------SVNIFSNYSRMDILIHSGGMQISYHSMLSL 672
              ||     :.:..|:|:. :|:..          .:.|....::.:.:..:||::.::.:..|.
 Worm   604 GNLRDWWDNTTSSKFNERT-QCIIEQYADVKLRGTDLRINGKLTQGENIADNGGIKQAFKAYKSY 667

  Fly   673 TGPIKGM-ARLPGL-NLTPTQIFFLVSAQELC------AESNYLGIDTNAPEFDNILGWLVAQGG 729
            .....|. ||||.. :||..|:||:..||..|      .::..|..|.::||...:...|..|..
 Worm   668 LEKHGGQEARLPQFESLTNEQLFFVGYAQVWCGAKTPETKTLLLLTDPHSPETARVNTVLTNQPE 732

  Fly   730 SATEVFKCPSGSMINVQKTCNV 751
            .| |.||||:||.:|..|.|.|
 Worm   733 FA-EAFKCPAGSPMNPTKRCVV 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..750	CDD:472708	152/722 (21%)
nep-1	NP_496490.2	M13	85..751	CDD:341056	152/721 (21%)