DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl16 and nep-1

DIOPT Version :9

Sequence 1:	NP_001097912.1	Gene:	Nepl16 / 43014	FlyBaseID:	FBgn0039277	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_496490.2	Gene:	nep-1 / 174787	WormBaseID:	WBGene00013926	Length:	754	Species:	Caenorhabditis elegans

Alignment Length:	802	Identity:	172/802 - (21%)
Similarity:	298/802 - (37%)	Gaps:	228/802 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 PILFLIST-------APSPLPRDCYMDGD-RCSPAVSAPPECSDPICE------AVASS------ 166
            ||:||||.       ....|||..|.:.| ..:...|......:.:.|      .|..|
Worm     8 PIVFLISCYALILCGTVDALPRAPYFNDDINKTTTTSEDKTVGNTVVEEEKKTYTVGDSEGYQEA 72

  Fly   167 ---IQARLNWNKDPCTEFKKFSC--WRNT---PNKNITNLIEMGNSQKSVDSQMLYLFQNKI--- 220
               :|..||.:.|||.:|.:::|  |.::   |: ::|:..:...:::.|.::|..|:::..
Worm    73 SRLLQKSLNLSLDPCDDFFEYACRAWVDSHPIPD-DLTSYSQFTATREKVLAEMRKLYEDNTSIP 136

  Fly   221 MNGSFGILHNLFESCLQQTTNSTVMHR-IFDSLG--GYLPV--GSVGPSSIAPL----------- 269
            .:.|..::..::.:|:....::.|..| :.:.:.  ||.|:  ......|...|
Worm   137 TSKSIALIKQIYNTCMDTEKHNAVGARDLLEKIKTYGYWPMVHNEKWRESTFDLTKLLSNTIQSR 201

  Fly   270 -IAKIYDLGPSPLVDLYHDLSYGRRPHILLIIS------GPSTSSTILERKIRWMSPKA----PP 323
             ::..:|.||:.     ...:..||   ||...      |.||....|:.|......||    ..
Worm   202 DVSVFFDFGPAE-----DSRNVSRR---LLSFDQGSLGLGYSTRDYYLDEKKYEKQMKAYRKYTI 258

  Fly   324 SRIRQGVPKLLADLIENFLPYF-------VSYAQRVSEKDTIFEFIKDLNKLQV-EHSRRGFWDS 380
            .::|                |:       |:.::..|:.|.|..|.|:..::.| |..||.:
Worm   259 GKVR----------------YYTEDAGMAVNESKIESDVDEIIAFEKEWAQILVAEEDRRNY--- 304

  Fly   381 TVLYNVSSLQDL---YPVLNWTLL------------IPQNWSGPIVVRNSDYLKALEYFLTKYPT 430
            |.||||....||   ..:::|..|            :..|.|  |::.:.:||:.:...|.....
Worm   305 TKLYNVRRFDDLKEYMSIIDWKKLTLSTTPFLVHSYLKTNPS--IIISDVEYLQKMNTLLQNTDP 367

  Fly   431 RVAHNSLLLL-------------------SALQILPRDYPSP--EVCTRSTMWALPELSSSLYIA 474
            |:..|.:||.                   .|.|:..|....|  :.|..|....|...|.|:|:.
Worm   368 RIVTNYILLRWAGSWSQEIGKKYEDLQQEFAFQMYGRKQRQPRWKDCVSSAGGKLSYASGSMYVR 432

  Fly   475 QHSSEDLKDTTKRAEII------FKS-------LKAHLKRAPSLKGAALVK--------LSALKI 518
            ::...:.|:||  .::|      |::       :.|..|:....|...::|        |:..|:
Worm   433 KYFDANAKNTT--LDMITDLQEAFRNMMHANDWMDAETKKYALEKADQMLKQIGYPDFILNDEKL 495

  Fly   519 QSQTW---------EGFSNTTDLLKSLQPLNITSECWFQNILEIYKKNKLEP-NDISLNGGSHDA 573
            ..  |         :.||...:  ||:|        |..|   .|.:..||| |.......:
Worm   496 DD--WYKGLEGAPEDSFSQLVE--KSIQ--------WRNN---FYYRRLLEPVNRFEFISSA--- 542

  Fly   574 WAYPIVSTIFYDTLSHSIVVPLSVILIPYFNAVLPPYLHYASVGVSIAKEI-------------- 624
                .|...||....::|..|..::..|:|:|..|..|:|..:|..|..||
Worm   543 ----AVVNAFYSPTRNAIAFPAGILQQPFFDARFPKALNYGGIGAVIGHEITHGFDDTGRQFDNV 603

  Fly   625 --LR-----SITKSFDEKAMRCVPH----------SVNIFSNYSRMDILIHSGGMQISYHSMLSL 672
              ||     :.:..|:|:. :|:..          .:.|....::.:.:..:||::.::.:..|.
Worm   604 GNLRDWWDNTTSSKFNERT-QCIIEQYADVKLRGTDLRINGKLTQGENIADNGGIKQAFKAYKSY 667

  Fly   673 TGPIKGM-ARLPGL-NLTPTQIFFLVSAQELC------AESNYLGIDTNAPEFDNILGWLVAQGG 729
            .....|. ||||.. :||..|:||:..||..|      .::..|..|.::||...:...|..|..
Worm   668 LEKHGGQEARLPQFESLTNEQLFFVGYAQVWCGAKTPETKTLLLLTDPHSPETARVNTVLTNQPE 732

  Fly   730 SATEVFKCPSGSMINVQKTCNV 751
            .| |.||||:||.:|..|.|.|
Worm   733 FA-EAFKCPAGSPMNPTKRCVV 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..749	CDD:301352	152/721 (21%)
nep-1	NP_496490.2	PepO	80..754	CDD:226118	156/730 (21%)
nep-1	NP_496490.2	M13	85..751	CDD:189000	152/721 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910