Protein Alignment Nepl16 and nep-5

DIOPT Version :10

• Sequence 1: NP_001097912.1
• Gene: Nepl16 / 43014
• FlyBaseID: FBgn0039277
• Length: 752
• Species: Drosophila melanogaster
• Sequence 2: NP_001364754.1
• Gene: nep-5 / 173933
• WormBaseID: WBGene00017393
• Length: 694
• Species: Caenorhabditis elegans
• Alignment Length: 809
• Identity: 161/809 - (19%)
• Similarity: 287/809 - (35%)
• Gaps: 243/809 - (30%)

  Fly    47 LSFKTP-------VGSKQMGKSDEIEMIDSANIENFNTRYNKNSIIGWICCAPCIWLRTSAAVHK 104
            |.||.|       |...::|..|.||     .::....|..           ||    |..||
 Worm    23 LFFKDPENKNKNHVSHVEIGVPDPIE-----ELQKLQNRPE-----------PC----TVLAV-- 65

  Fly   105 MAITSATLLVTTLLVASPILFLIST-----------APSP---------LPRDCYMDGDRCSPAV 149
                     :|||::...::|.:..           .|.|         ||
 Worm    66 ---------ITTLVILVLLIFALGALGLHDISAFKWEPKPQKALRIMLDLP-------------- 107

  Fly   150 SAPPECSDPICEAVASSIQARLNWNKDPCTEFKKFSC-WRNTPNKNITNLIEMGNSQKSVDSQML 213
                 |....|...::.:...::.:.:||..|....| ..|...|:...|:::.|.|:..|
 Worm   108 -----CQTKECVKYSAELLELMDSSVNPCENFHHHVCNGFNPRKKDFERLMKLINIQEKPD---- 163

  Fly   214 YLFQNKIMNGSFGILHNLFESCLQQTTNSTVMHRIFDSLGGYLPVGSVGPSSIAPLIAKIYDLGP 278
               ..|.:|    ::..:...|....|..  :|::     |.|. ..:.|....||:...:....
 Worm   164 ---HRKAVN----VVRRMLSKCAMGKTEE--IHQV-----GRLS-SIILPGLPFPLLNNSWTKPS 213

  Fly   279 SPLVDLYHDLSYGR------RPHILL--------IISGPSTSSTILERKIRWMSPKAPPSRIRQG 329
            .|:.......:|..      ..||:|        :...||:.|......::..||.....:.|.
 Worm   214 DPISTSNSSTTYSYPFLTKILAHIILHNPDDAGFVGIKPSSDSEFSLFVVKPFSPVLTNFKFRN- 277

  Fly   330 VPKLLADLIENFLPYFVSYAQRVSEKDT----IFEF-----IKDLNKLQVEHSRRGFWDSTVLYN 385
                :.|:::...|          |..|    ..||     :.|:.|||.:..:..|.....:.|
 Worm   278 ----MYDILKRNAP----------ESSTNGMIDLEFDRQRQLNDVIKLQTKLEKIEFKADPEVVN 328

  Fly   386 VSSLQDLYPVLNWTLLIPQNW--SGPIVVR------NSDYLKALEYFLTKYPTRVAHNSLLLLSA 442
            ::.:|...|:::|..|| .:|  :|...::      |:.|.:.:...::..|:...:|.|.|..:
 Worm   329 LTEIQRQMPIIDWKRLI-DSWIPNGYAHLKEKVYGFNTSYYEEINAIISSTPSETIYNFLFLRFS 392

  Fly   443 LQILPRDYPS--PEVCTRSTMWALPELSSSL--YIAQHSSEDLKDTTKRAEIIFKSLKAHLKRAP 503
            .:.|..:..|  .:.|       |.:||:::  .|..:.||: .:.......:..::|..|||:
 Worm   393 FKFLRTEVASDLEDTC-------LHQLSTTIPGKIVLYGSEE-PEALNLLNGMLHTIKDQLKRS- 448

  Fly   504 SLKGAALVKLSALK--------------IQSQTWEGFSNTTDLLKSLQPLNITSECWF----QNI 550
                     |:.||              .:::|..||:. .||:..|.. .||.|..:    ||:
 Worm   449 ---------LATLKWMDSRGIEEAQKKFNKTKTVFGFTG-EDLIDELVG-KITPESNYISTLQNV 502

  Fly   551 LEIYKKN---KLEPNDIS--LNGGSHDAWAYPIVSTIFYDTLSHSIVVPLSVILIPYFNAVLPPY 610
            |....:|   .:..|:::  ||            |.:||....:.|.:..:::..|:.:|.||.|
 Worm   503 LLWQTRNMFKSVAENNVTVFLN------------SEVFYSVEKNEITISRALLHYPFMSANLPNY 555

  Fly   611 LHYASVGVSIAKEILRSITKSFDEKAMRCVPHSVN-------IFSNYSRMDILIHSGGMQ----- 663
            .::|    :||.:||..:...|||:. |......|       ....|.::.:....|.||
 Worm   556 TNFA----TIASKILPQMIHIFDERG-RFYDSDGNHRNWWNTETERYFQIIVQCFDGMMQNVFGV 615

  Fly   664 ---ISYHSMLSLTGPIKGMARLPGLNLTPTQ-IFFLVSAQELCAESNYLGIDTNAPEFDNILGWL 724
               |.:::..|...|   .|.|||:..:..: :||....:.:|         |:.|  ||:...|
 Worm   616 SVSIGWNAYDSTKEP---YATLPGIQQSSDEALFFYSMVKTMC---------TSDP--DNVNEAL 666

  Fly   725 --VAQGGSATEVFKCPSGSMINVQKTCNV 751
              |.|..||   |||.:|:.:|....|.:
 Worm   667 ASVPQFNSA---FKCNNGTKMNPPTKCKL 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..750	CDD:472708	135/650 (21%)
nep-5	NP_001364754.1	GluZincin	128..691	CDD:472708	135/651 (21%)