Protein Alignment Nepl16 and Mme

DIOPT Version :10

• Sequence 1: NP_001097912.1
• Gene: Nepl16 / 43014
• FlyBaseID: FBgn0039277
• Length: 752
• Species: Drosophila melanogaster
• Sequence 2: NP_032630.2
• Gene: Mme / 17380
• MGIID: 97004
• Length: 750
• Species: Mus musculus
• Alignment Length: 823
• Identity: 161/823 - (19%)
• Similarity: 275/823 - (33%)
• Gaps: 276/823 - (33%)

  Fly   105 MAITSATLLVTTLLVASPILFLISTAPSPLPRDCYMDGDRCSPAVSAPPECSDPICEAVASSIQA 169
            :.|:.:.|::...::|..::.|.:|         |.||           .|....|...|:.:..
Mouse    27 LEISLSVLVLLLTIIAVTMIALYAT---------YDDG-----------ICKSSDCIKSAARLIQ 71

  Fly   170 RLNWNKDPCTEFKKFSC--WRNTPNKNITNLIEMGNSQKSVDSQMLYLFQNKIMNGSFGILHN-- 230
            .::.:.:|||:|.|::|  |..      .|:|...:|:.|                :|.||.:
Mouse    72 NMDASVEPCTDFFKYACGGWLK------RNVIPETSSRYS----------------NFDILRDEL 114

  Fly   231 ------------------------LFESCLQQTTNSTVMHRIFDSLGGY-----------LPVGS 260
                                    |:.||:.::.        .||.||.           .||.|
Mouse   115 EVILKDVLQEPKTEDIVAVQKAKTLYRSCINESA--------IDSRGGQPLLKLLPDIYGWPVAS 171

  Fly   261 -----------VGPSSIAPLIAKIYDLGPSPLVDLYHDLSYGRRPHILLIISGPSTSSTILERKI 314
                       ....|||.|.:|                 ||::..|...:.....:||  :..|
Mouse   172 DNWDQTYGTSWTAEKSIAQLNSK-----------------YGKKVLINFFVGTDDKNST--QHII 217

  Fly   315 RWMSPK-APPSRIRQGVPKLLADLIENFLPYFVSYAQRVS--------------EKDTIFEFIKD 364
            .:..|: ..|||.......:..:....::.:.:|.|:.:.              |.:.:.|..|:
Mouse   218 HFDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEQSLPIDENQLSLEMNKVMELEKE 282

  Fly   365 LNKLQVEHSRRGFWDSTVLYNVSSLQDLYPVLNWTLLI---PQNWSG-----------------P 409
            :.....:...|.  |..:|||..:|..|..  |::|.:   ..:||.                 .
Mouse   283 IANATTKPEDRN--DPMLLYNKMTLAKLQN--NFSLEVNGKSFSWSNFTNEIMSTVNINIQNEEE 343

  Fly   410 IVVRNSDYLKALEYFLTKYPTRVAHNSL---LLLSALQILPRDYPSPEVCTRSTMWALPELSSS- 470
            :||...:||..|:..||||..|...|.:   .::..:..|.|:|.......|..::.....:::
Mouse   344 VVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATW 408

  Fly   471 -----------------LYI-------AQHSSEDLKDTTKRAEIIFKSL------KAHLKRAPSL 505
                             ||:       ::|..|||  ..:..|:..::|      .|..|:....
Mouse   409 RRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDL--IAQIREVFIQTLDDLTWMDAETKKKAEE 471

  Fly   506 KGAALVKLSALKIQSQTWEGF-----SNTTDLLKSLQPLNITSECWFQNILEIYK-------KNK 558
            |        ||.|:.:.  |:     ||...|......||...:.:|:||::..|       |..
Mouse   472 K--------ALAIKERI--GYPDDIISNENKLNNEYLELNYREDEYFENIIQNLKFSQSKQLKKL 526

  Fly   559 LEPNDISLNGGSHDAW-AYPIVSTIFYDTLSHSIVVPLSVILIPYFNAVLPPYLHYASVGVSIAK 622
            .|..|       .|.| :...|...||.:..:.||.|..::..|:|:|.....|:|..:|:.|..
Mouse   527 REKVD-------KDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGH 584

  Fly   623 EILRSITKSFDEKAMR----------CVPHSVNIFSNYSRMDILIH-------SGGMQI------ 664
            |    ||..||:....          ....|.|.|.:.|:..:..:       :||..:
Mouse   585 E----ITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFSWDLAGGQHLNGINTL 645

  Fly   665 ---------------SYHSMLSLTGPIKGMARLPGLNLTPTQIFFLVSAQELCA------ESNYL 708
                           :|.:.:...|..|   .||||:|...|:|||..||..|.      ..|.:
Mouse   646 GENIADNGGIGQAYRAYQNYVKKNGEEK---LLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSI 707

  Fly   709 GIDTNAPEFDNILGWLVAQGGSATEVFKCPSGSMINVQKTCNV 751
            ..|.::|....|:|.| .......:.|.|...|.:|.::.|.|
Mouse   708 KTDVHSPGNFRIIGTL-QNSAEFADAFHCRKNSYMNPERKCRV 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..750	CDD:472708	148/749 (20%)
Mme	NP_032630.2	Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	77..748	CDD:341056	148/750 (20%)