Protein Alignment Nepl16 and nep-13

DIOPT Version :10

• Sequence 1: NP_001097912.1
• Gene: Nepl16 / 43014
• FlyBaseID: FBgn0039277
• Length: 752
• Species: Drosophila melanogaster
• Sequence 2: NP_001342017.1
• Gene: nep-13 / 173672
• WormBaseID: WBGene00018196
• Length: 732
• Species: Caenorhabditis elegans
• Alignment Length: 825
• Identity: 146/825 - (17%)
• Similarity: 291/825 - (35%)
• Gaps: 230/825 - (27%)

  Fly    55 SKQMGKSDEIEMIDSANIENFNTRYNKNSIIGWICCAPCIWLRTSAAVHKMAITSATLLVTTLLV 119
            |:.:..:..:|:.:....|.     :.|..:...|..|.|           :|....:::...:.
 Worm     9 SRLLSSTQNLEVEEDGEEEG-----DDNEKVSKCCIYPLI-----------SIIICLVIIAICMG 57

  Fly   120 ASPILFLISTAPSPLPRDCYMDGDRCSPAVSAPPECSDPICEAVASSIQARLNW---NKDPCTEF 181
            |..:.:.:.:||..:   |..|.::....      |....|..::|::   |||   |.|||.:|
 Worm    58 AVIVFWRMDSAPQAI---CKTDHNKTRDV------CKTAECITLSSTL---LNWQNTNIDPCEDF 110

  Fly   182 KKFSCWR---NTPNKNITNLIEMGNSQKSVDSQML--YLFQNK-IMNGSFGILHNLFESCL---- 236
            .::||.|   :|.|..|     ..|.:.::..:::  ::.:|: ..:.|...|..|:|.|.
 Worm   111 YEYSCGRYQEHTLNDGI-----RANEKDTIVMKLIRQFVLKNQSTTSNSENALMLLYEKCSLRYR 170

  Fly   237 -----QQTTNSTVMHRIFDSLG--GYLPVGSVG-----------PSSIAPLIAKIYDLGPSPLVD 283
                 |:|  ..:...:|:::.  |..|:....           .|::|.:....:.|..:.:::
 Worm   171 MENRHQET--EVIQREVFENIRKIGSWPIADKNWNSSHFNLNNMLSNMASIHMLPFGLFETRVIE 233

  Fly   284 LYHDLSYGRRPHILLIISGPSTSSTILERKIRWMSPKAPPSRIRQGVP-----KLLADLIENFLP 343
            ||                  ..::|..:..||       |::::..:|     :.:.||:.  :.
 Worm   234 LY------------------PMNTTAKQLVIR-------PTKLKFSIPQEELVRAIRDLLS--VN 271

  Fly   344 YFVSYAQRVSEKDTI--FEFIKDLNKLQVEHSRRGFWDSTVLYNVSSLQDLYPVLNWTLLIPQ-- 404
            ...|..::|.| |..  |...|::..:.::...:.       ..:|.||...|.:::..:|..
 Worm   272 GITSIMKKVKE-DVAESFALDKEIGNIHIDPQPKP-------ATLSELQKAVPDIDFERIIKSYL 328

  Fly   405 -----NWSG----------------------------PIVVRNSDYLKALE--YFLTKYPTRVAH 434
                 |||.                            |.::.|..:||.:|  ||.....|:|
 Worm   329 NPKTGNWSSLRTKIFSARFELFFGKNNNLSSIIARTKPRILANYLFLKYIEYAYFFFFDNTKV-- 391

  Fly   435 NSLLLLSALQILPRDYPSPEVCTRSTMWALPELSSSLYIAQH-------SSEDLKDTTKRA--EI 490
                           :...:.||.....:||..|..:::..|       .:.::.:..|.|  ||
 Worm   392 ---------------FSDDDFCTEVVTTSLPRASLRVFVRNHFKKENMAVASEIVEVVKTAYVEI 441

  Fly   491 IFKSLKAHLKRAPSLKGAALVKLSALKIQSQTWEGFSNTTDLLKSLQPLNITSECWFQNILEIYK 555
            |..|...|    .|.:.:|:.|:..:|......|.:..|..|.:..:.|.::....|..::....
 Worm   442 INNSTWLH----NSTRESAIEKVVKMKKVIGYTEEYERTGALDEMFETLQLSRSDSFFVLMTKVN 502

  Fly   556 KNKLEPNDISLNGGSHDAWAYPI----VSTIFYDTLSHSIVVPLSVILIPYFNAVLPPYLHYASV 616
            :.|:|.   .::..|.|:...||    ::..||....:.:.|.:..:..|.|:...|.|:..|.|
 Worm   503 RFKIEQ---LMDFVSSDSLLNPIEPLVMANAFYFPTKNLLNVLVPFLDKPLFDFKYPRYVAMAGV 564

  Fly   617 GVSIAKEI---------------------LRSITKSFDEKAMRCVPHSVNIFSNYSRMDILIHSG 660
            |..:|.||                     .|..|:.:|.:: .|....   |:|:..........
 Worm   565 GRVLAHEIGHAFDINGRQTDEIGRTRDWWTREDTEEYDRRS-ECFAEQ---FTNFKDPSFKGKQN 625

  Fly   661 GMQISYHSMLSLTGPIKGMARLPGLNLTPTQ------------IFFLVSAQELCAE-------SN 706
            |.::....:....|..........:|||..|            ::|.|:|.:.||.       |:
 Worm   626 GTEVLAEIIADALGMEASWIAFKKINLTEEQGLIQFEDHDFGKLYFQVAALDFCAPSRIEERYSD 690

  Fly   707 YLGIDTNAPEFDNILGWLVAQGGSATEVFKCPSGSMINVQKTCNV 751
            .|...||....:...    :...:..:.:|||.||.:|..:.|::
 Worm   691 QLSHPTNKFRINGAF----SNSRAFADTYKCPVGSKMNPVQRCDM 731

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..750	CDD:472708	125/698 (18%)
nep-13	NP_001342017.1	M13	104..729	CDD:341056	125/698 (18%)