DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl16 and EEF1AKMT4-ECE2

DIOPT Version :9

Sequence 1:	NP_001097912.1	Gene:	Nepl16 / 43014	FlyBaseID:	FBgn0039277	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_055508.3	Gene:	EEF1AKMT4-ECE2 / 110599583	HGNCID:	53615	Length:	883	Species:	Homo sapiens

Alignment Length:	833	Identity:	163/833 - (19%)
Similarity:	274/833 - (32%)	Gaps:	270/833 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 WLRTSAAVH-------------------------KMAITSATLLVTTLLVASPILFLISTAPSPL 134
            |..:|..||                         ::.:..|:||:..||:...:...:.....|.
Human   144 WTVSSEGVHTVDQVLSEVGFQKGTRQLLGSRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPS 208

  Fly   135 PRDCYMDGDRCSPAVSAPPECSDPICEAVASSIQARLNWNKDPCTEFKKFSC--W-RNTPNKNIT 196
            ...|..:.                 |..||..|...|:....||.:|.:|||  | |..|..:..
Human   209 HSTCLTEA-----------------CIRVAGKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGR 256

  Fly   197 NLIEMGNSQKSVDSQML-YLFQNKIMNGSFGI---LHNLFESCLQQTTNSTVMHRIFDSLGGYLP 257
            :.....||....:..:| :|.:|...|.|...   ....:.||||
Human   257 SRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQ-------------------- 301

  Fly   258 VGSVGPSSIAPLIAKIYDLGPSPLVDLYHDL-----------------------SYGRRPHILLI 299
                        :.:|.:||..||.||...:                       :|...|...:.
Human   302 ------------VERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFTVY 354

  Fly   300 ISGPSTSSTILERKIRWMSPKAPPSRIRQGVPKLLADLIENFLPYFVSYAQRVSEKDTI---FEF 361
            ||..|.||.               |.:.|      .|....|||....|..|.:.:..:   .::
Human   355 ISADSKSSN---------------SNVIQ------VDQSGLFLPSRDYYLNRTANEKVLTAYLDY 398

  Fly   362 IKDLNKL-------------QV-------------EHSRRGFWDSTVLY---NVSSLQDLYPVLN 397
            :::|..|             ||             :..||   |...:|   ::|.||.|.|.::
Human   399 MEELGMLLGGRPTSTREQMQQVLELEIQLANITVPQDQRR---DEEKIYHKMSISELQALAPSMD 460

  Fly   398 WT-----LLIPQNWSG--PIVVRNSDYLKALEYFLTKYPTRVAHNSL---LLLSALQILPRDY-- 450
            |.     ||.|...|.  |:||...|||:.:...:.:....:.:|.|   |:......|.|.:
Human   461 WLEFLSFLLSPLELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFES 525

  Fly   451 -----------------PSPEVCTRSTMWALPELSSSLYIAQHSSEDLKDTTKRAEIIFKSLKAH 498
                             |..:.|..:|..||.....||::........|:.   ||.:...::..
Human   526 AQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEI---AEGMISEIRTA 587

  Fly   499 LKRA--------PSLKGAALVKLSAL-------------KIQSQTWEGFSNTTDLLKSLQPLNIT 542
            .:.|        ...:.||..|..|:             |.....::|:             .|:
Human   588 FEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGY-------------EIS 639

  Fly   543 SECWFQNILEIYKKNKLEPNDISLNGGSHDAWAY-PIVSTIFYDTLSHSIVVPLSVILIPYFNAV 606
            .:.:|||:|.:|..:.....|......|.|.|:. |.....:|....:.||.|..::..|::...
Human   640 EDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARN 704

  Fly   607 LPPYLHYASVGVSIAKEILRSITKSFDEK--------------------AMR----CVPHSVNIF 647
            .|..|::..:||.:..|    :|.:||::                    |.|    |:....|.:
Human   705 HPKALNFGGIGVVMGHE----LTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQY 765

  Fly   648 S-NYSRM-------DILIHSGGMQISYHSMLSLTGPIKGMARLPGLNLTPTQIFFLVSAQELCA- 703
            . |..|:       :.:..:||::.:|::..:.........:||.:.||..|:||:..||..|:
Human   766 QVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSV 830

  Fly   704 ---ESNYLGI--DTNAPEFDNILGWLVAQGGSATEVFKCPSGSMINVQKTCNV 751
               ||::.|:  |.::|....:||.| :........|.||.||.:|..:.|.|
Human   831 RTPESSHEGLVTDPHSPARFRVLGTL-SNSRDFLRHFGCPVGSPMNPGQLCEV 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..749	CDD:301352	145/723 (20%)
EEF1AKMT4-ECE2	NP_055508.3	Methyltransferase-like region. /evidence=ECO:0000305	1..160		4/15 (27%)
		Methyltransf_25	62..>128	CDD:316196
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:P0DPD7	88..89
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:P0DPD7	113..114
		M13	232..881	CDD:189000	145/725 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910