DRSC/TRiP Functional Genomics Resources

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Protein Alignment fd96Cb and FOXK2

DIOPT Version :9

Sequence 1:NP_524496.1 Gene:fd96Cb / 43011 FlyBaseID:FBgn0004898 Length:271 Species:Drosophila melanogaster
Sequence 2:NP_004505.2 Gene:FOXK2 / 3607 HGNCID:6036 Length:660 Species:Homo sapiens


Alignment Length:240 Identity:71/240 - (29%)
Similarity:100/240 - (41%) Gaps:56/240 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 DQKPPYSYISLTAMAIIHSPQRLLPLSEIYRFIMDQFPFYRKNTQKWQNSLRHNLSFNDCFIKVP 75
            |.||||||..|...||..:|.:.|.|:.||..|...:|:||...:.||||:|||||.|..|||||
Human   256 DSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVP 320

  Fly    76 RNVTKAGKGSYWTLHPMAFDMFENGSLLRRRKR----FRVKQLEKDISNWKLAAAANTEMVTHYL 136
            |:..:.||||:|.:.|.:.......:..:||.|    ||..                       |
Human   321 RSQEEPGKGSFWRIDPASESKLIEQAFRKRRPRGVPCFRTP-----------------------L 362

  Fly   137 DDQLTQMAFADPARHGHVLANASAAQMSPYKATPPILPTTVTQLP-------ARPKRAFTIESLM 194
            ....::.|.|.|...|.:.|::|.||      ||..|....:..|       |:||.|...|:..
Human   363 GPLSSRSAPASPNHAGVLSAHSSGAQ------TPESLSREGSPAPLEPEPGAAQPKLAVIQEARF 421

  Fly   195 APDPASTP--------------NEGLVPMEY--GSPDAVALEKPP 223
            |.....:|              .:.:.|:.|  .:|...:..:||
Human   422 AQSAPGSPLSSQPVLITVQRQLPQAIKPVTYTVATPVTTSTSQPP 466

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fd96CbNP_524496.1 FH 13..101 CDD:214627 40/87 (46%)
Alpha_kinase 106..>194 CDD:295997 22/98 (22%)
FOXK2NP_004505.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36
FHA 47..154 CDD:238017
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 85..104
Required for interaction with DVL2 and SUDS3. /evidence=ECO:0000269|PubMed:25805136 129..171
COG5025 <180..577 CDD:227358 71/240 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 203..260 2/3 (67%)
Forkhead 257..343 CDD:365978 40/85 (47%)
DNA-binding, major groove. /evidence=ECO:0000269|PubMed:16624804 300..318 11/17 (65%)
DNA-binding, minor groove. /evidence=ECO:0000269|PubMed:16624804 328..332 3/3 (100%)
DNA-binding, minor groove. /evidence=ECO:0000269|PubMed:16624804 348..353 2/4 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 359..407 14/76 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 610..632
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000010
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2114
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.940

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