DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd96Cb and FOXI3

DIOPT Version :9

Sequence 1:	NP_524496.1	Gene:	fd96Cb / 43011	FlyBaseID:	FBgn0004898	Length:	271	Species:	Drosophila melanogaster
Sequence 2:	NP_001129121.1	Gene:	FOXI3 / 344167	HGNCID:	35123	Length:	420	Species:	Homo sapiens

Alignment Length:	277	Identity:	90/277 - (32%)
Similarity:	122/277 - (44%)	Gaps:	41/277 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KPPYSYISLTAMAIIHSPQRLLPLSEIYRFIMDQFPFYRKNTQKWQNSLRHNLSFNDCFIKVPRN 77
            :|||||.:|.||||..:|:|.|.||.||:|:.|.||||:::...||||:|||||.||||.||||:
Human   145 RPPYSYSALIAMAIQSAPERKLTLSHIYQFVADSFPFYQRSKAGWQNSIRHNLSLNDCFKKVPRD 209

  Fly    78 VTKAGKGSYWTLHPMAFDMFENGSLLRRRKRFRVKQLEKDISNWKLAAAANTEMVTHYLDDQLTQ 142
            ....|||:||||.|....||:||:..|:|||      ..:.||.. ..||.|......|...|..
Human   210 EDDPGKGNYWTLDPNCEKMFDNGNFRRKRKR------RSEASNGS-TVAAGTSKSEEGLSSGLGS 267

  Fly   143 MAFADP--------ARHGHV------LANASAAQMSPYKATPPILPTTVTQLPA-------RPKR 186
            .....|        .|..|.      ..:.:::...|...:.|.|.|..:.|.:       ..:|
Human   268 GVGGKPEEESPSTLLRPSHSPEPPEGTKSTASSPGGPMLTSTPCLNTFFSSLSSLSVSSSVSTQR 332

  Fly   187 AFTIESLMAPDPASTPNEGL---VPMEYGSPDAVALEKPPFNLPFNFNELAAQYQLYFPSFFYNG 248
            |......:....|..|:.|:   ..:...|.|.:.|.    |...|.....:.|...||:....|
Human   333 ALPGSRHLGIQGAQLPSSGVFSPTSISEASADTLQLS----NSTSNSTGQRSSYYSPFPASTSGG 393

  Fly   249 QYGNIPCYQKTPPLFHN 265
            |....    .:|  |||
Human   394 QSSPF----SSP--FHN 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd96Cb	NP_524496.1	FH	13..101	CDD:214627	51/87 (59%)
fd96Cb	NP_524496.1	Alpha_kinase	106..>194	CDD:295997	20/108 (19%)
FOXI3	NP_001129121.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	103..122
		Forkhead	145..231	CDD:278670	50/85 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	234..306		15/78 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..396		9/35 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11829
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010