Protein Alignment fd96Cb and FOXA2

DIOPT Version :10

• Sequence 1: NP_524496.1
• Gene: fd96Cb / 43011
• FlyBaseID: FBgn0004898
• Length: 271
• Species: Drosophila melanogaster
• Sequence 2: NP_068556.2
• Gene: FOXA2 / 3170
• HGNCID: 5022
• Length: 463
• Species: Homo sapiens
• Alignment Length: 294
• Identity: 110/294 - (37%)
• Similarity: 154/294 - (52%)
• Gaps: 48/294 - (16%)

  Fly     2 PRPLKMSYGDQKPPYSYISLTAMAIIHSPQRLLPLSEIYRFIMDQFPFYRKNTQKWQNSLRHNLS 66
            |:..:.||...|||||||||..|||..||.::|.|||||::|||.|||||:|.|:||||:||:||
Human   154 PKTYRRSYTHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLS 218

  Fly    67 FNDCFIKVPRNVTKAGKGSYWTLHPMAFDMFENGSLLRRRKRFRVKQLEKDISNWKLAAAANTEM 131
            |||||:||||:..|.||||:|||||.:.:|||||..|||:|||:   .||.::..:.|.||.:
Human   219 FNDCFLKVPRSPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFK---CEKQLALKEAAGAAGS-- 278

  Fly   132 VTHYLDDQLTQMAFADPARHGHVLANAS---AAQMSPYKATPPILPTT---VTQLPARPKRAFTI 190
                 ..:....|.|..|:.|.....||   |...||:.:..|.....   :.:|...|..|
Human   279 -----GKKAAAGAQASQAQLGEAAGPASETPAGTESPHSSASPCQEHKRGGLGELKGTPAAA--- 335

  Fly   191 ESLMAPDPASTPNE---------------GLVPMEYGSPDAVALEKPPFNLPFNFNELAAQYQLY 240
              |..|:||.:|.:               ||.|..:..|:    ....||.||:.|.|.:..|.:
Human   336 --LSPPEPAPSPGQQQQAAAHLLGPPHHPGLPPEAHLKPE----HHYAFNHPFSINNLMSSEQQH 394

  Fly   241 FPSFFYNGQYG-NIPCYQKTPPLFH----NGPLP 269
            ..|..::..:. ::..|::   :.|    ..|:|
Human   395 HHSHHHHQPHKMDLKAYEQ---VMHYPGYGSPMP 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fd96Cb	NP_524496.1	FH_FOX	1..110	CDD:469596	70/107 (65%)
FOXA2	NP_068556.2	Forkhead_N	23..164	CDD:369872	3/9 (33%)
		FH_FOXA2	163..264	CDD:410813	68/103 (66%)
		HNF_C	379..452	CDD:430552	11/50 (22%)