DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd96Cb and FOXB1

DIOPT Version :9

Sequence 1:	NP_524496.1	Gene:	fd96Cb / 43011	FlyBaseID:	FBgn0004898	Length:	271	Species:	Drosophila melanogaster
Sequence 2:	NP_036314.2	Gene:	FOXB1 / 27023	HGNCID:	3799	Length:	325	Species:	Homo sapiens

Alignment Length:	300	Identity:	117/300 - (39%)
Similarity:	153/300 - (51%)	Gaps:	67/300 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPRPLKMSYGDQKPPYSYISLTAMAIIHSPQRLLPLSEIYRFIMDQFPFYRKNTQKWQNSLRHNL 65
            ||||.:.:|.||||||||||||||||..||:::|||||||:||||:||:||:|||:|||||||||
Human     1 MPRPGRNTYSDQKPPYSYISLTAMAIQSSPEKMLPLSEIYKFIMDRFPYYRENTQRWQNSLRHNL 65

  Fly    66 SFNDCFIKVPRNVTKAGKGSYWTLHPMAFDMFENGSLLRRRKRFRVKQLEKDISNWKLAAAANTE 130
            ||||||||:||...:.||||:|.|||...|||||||.|||||||:|  |:.|
Human    66 SFNDCFIKIPRRPDQPGKGSFWALHPSCGDMFENGSFLRRRKRFKV--LKSD------------- 115

  Fly   131 MVTHYLDDQLTQMAFADPARHGHVLANASAAQMSPYKATPPILPTTVTQLPARPKRAFTIESLMA 195
                       .:|.:.||.....|...:..::|       .|..:.|.||..|..|:.:..:..
Human   116 -----------HLAPSKPADAAQYLQQQAKLRLS-------ALAASGTHLPQMPAAAYNLGGVAQ 162

  Fly   196 PDPASTP--NEGLVPMEYGSPDAV---ALEKPP--FNLPFNFNELAAQYQLYFPSFFYNGQYGNI 253
            |.....|  .|.::..||..|..:   |::..|  :.||.....:.:.....:|..:  |..|.|
Human   163 PSGFKHPFAIENIIAREYKMPGGLAFSAMQPVPAAYPLPNQLTTMGSSLGTGWPHVY--GSAGMI 225

  Fly   254 PCYQKTP----------------PLFHNG-------PLPV 270
            .  ..||                ||.|..       |:|:
Human   226 D--SATPISMASGDYSAYGVPLKPLCHAAGQTLPAIPVPI 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd96Cb	NP_524496.1	FH	13..101	CDD:214627	66/87 (76%)
fd96Cb	NP_524496.1	Alpha_kinase	106..>194	CDD:295997	18/87 (21%)
FOXB1	NP_036314.2	FH_FOXB2	1..110	CDD:410817	81/108 (75%)
FOXB1	NP_036314.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159001
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG3562
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3922
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1236900at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	1	1.000	-	-		mtm8587
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.830