DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd96Cb and FOXD3

DIOPT Version :9

Sequence 1:	NP_524496.1	Gene:	fd96Cb / 43011	FlyBaseID:	FBgn0004898	Length:	271	Species:	Drosophila melanogaster
Sequence 2:	NP_036315.1	Gene:	FOXD3 / 27022	HGNCID:	3804	Length:	478	Species:	Homo sapiens

Alignment Length:	252	Identity:	96/252 - (38%)
Similarity:	125/252 - (49%)	Gaps:	50/252 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KPPYSYISLTAMAIIHSPQRLLPLSEIYRFIMDQFPFYRKNTQKWQNSLRHNLSFNDCFIKVPRN 77
            |||||||:|..|||:.|||:.|.||.|..||.::||:||:....||||:|||||.||||:|:||.
Human   141 KPPYSYIALITMAILQSPQKKLTLSGICEFISNRFPYYREKFPAWQNSIRHNLSLNDCFVKIPRE 205

  Fly    78 VTKAGKGSYWTLHPMAFDMFENGSLLRRRKRFRVKQLE----------KDISNWKLAAAANTEMV 132
            ....|||:||||.|.:.|||:|||.|||||||:..|.|          :....:.|||||.....
Human   206 PGNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFKRHQQEHLREQTALMMQSFGAYSLAAAAGAAGP 270

  Fly   133 ---THYLDDQLTQMAFADPARHGHVLANASAAQMSPYKATP--PILPTTVTQLPA----RPKRAF 188
               .:.|.......|::.||  ....|.|:||...||...|  |:||..|..||:    |...||
Human   271 YGRPYGLHPAAAAGAYSHPA--AAAAAAAAAALQYPYALPPVAPVLPPAVPLLPSGELGRKAAAF 333

  Fly   189 -----------------------------TIESLMAPDPASTPNEGLVPMEYGSPDA 216
                                         |..||:..:|::.|:..:..:..|.|.|
Human   334 GSQLGPGLQLQLNSLGAAAAAAGTAGAAGTTASLIKSEPSARPSFSIENIIGGGPAA 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd96Cb	NP_524496.1	FH	13..101	CDD:214627	52/87 (60%)
fd96Cb	NP_524496.1	Alpha_kinase	106..>194	CDD:295997	33/135 (24%)
FOXD3	NP_036315.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..136
FOXD3	NP_036315.1	Forkhead	141..227	CDD:278670	51/85 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.900