DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fd96Cb and FOXO3

DIOPT Version :10

Sequence 1:NP_524496.1 Gene:fd96Cb / 43011 FlyBaseID:FBgn0004898 Length:271 Species:Drosophila melanogaster
Sequence 2:NP_001446.1 Gene:FOXO3 / 2309 HGNCID:3821 Length:673 Species:Homo sapiens


Alignment Length:239 Identity:59/239 - (24%)
Similarity:96/239 - (40%) Gaps:71/239 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SYISLTAMAIIHSPQRLLPLSEIYRFIMDQFPFYR-----KNTQKWQNSLRHNLSFNDCFIKVPR 76
            ||..|...||..||.:.|.||:||.:::...|:::     .::..|:||:|||||.:..|::|..
Human   161 SYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQN 225

  Fly    77 NVTKAGKGSYWTLHPMAFDMFENGSLLRRRKRFRVKQLEKDISNWKLAAAANTEMVTHYLDDQLT 141
            ..|  ||.|:|.::|   |..::|...|||      .:..|.||                  :.|
Human   226 EGT--GKSSWWIINP---DGGKSGKAPRRR------AVSMDNSN------------------KYT 261

  Fly   142 QMAFADPARHGHVLANASAAQMSPYKATPPILPTTVTQLPARP-------------------KRA 187
            :       ..|......:|.|.:|..|...  |:.:::.|..|                   ..|
Human   262 K-------SRGRAAKKKAALQTAPESADDS--PSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNA 317

  Fly   188 FTIESLMAPDPAST-------PNEGLVPMEYGSPDAV--ALEKP 222
            .|:...::|..|||       .:..|.||.|.|..::  ::.||
Human   318 STVSGRLSPIMASTELDEVQDDDAPLSPMLYSSSASLSPSVSKP 361

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fd96CbNP_524496.1 FH_FOX 1..110 CDD:469596 34/97 (35%)
FOXO3NP_001446.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..153
Required for mitochondrial import. /evidence=ECO:0000269|PubMed:23283301 80..108
FH_FOXO3 157..239 CDD:410835 29/82 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..302 20/106 (19%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:17940099, ECO:0000269|PubMed:29445193 242..259 7/40 (18%)
Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000269|PubMed:15084260 300..673 13/62 (21%)
FOXO_KIX_bdg 432..511 CDD:465228
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 536..587
FOXO-TAD 606..644 CDD:435506
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.