DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fd96Cb and FOXC1

DIOPT Version :10

Sequence 1:NP_524496.1 Gene:fd96Cb / 43011 FlyBaseID:FBgn0004898 Length:271 Species:Drosophila melanogaster
Sequence 2:NP_001444.2 Gene:FOXC1 / 2296 HGNCID:3800 Length:553 Species:Homo sapiens


Alignment Length:238 Identity:90/238 - (37%)
Similarity:125/238 - (52%) Gaps:42/238 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 PRPLKMSYGDQKPPYSYISLTAMAIIHSPQRLLPLSEIYRFIMDQFPFYRKNTQKWQNSLRHNLS 66
            |:|..|    .|||||||:|..|||.::|.:.:.|:.||:||||:|||||.|.|.||||:|||||
Human    71 PQPKDM----VKPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRDNKQGWQNSIRHNLS 131

  Fly    67 FNDCFIKVPRNVTKAGKGSYWTLHPMAFDMFENGSLLRRRKRFRVKQLEKDISNWKLAAAANTEM 131
            .|:||:||||:..|.||||||||.|.:::||||||.||||:||:.|...||              
Human   132 LNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDAVKD-------------- 182

  Fly   132 VTHYLDDQLTQMAFADPARHGHVLANASAAQM---SPYKATPPI----LPTTVTQLPARPKRAFT 189
                 .::..::...:|...|.....|...|.   :|....||:    :.|.....|:.|:....
Human   183 -----KEEKDRLHLKEPPPPGRQPPPAPPEQADGNAPGPQPPPVRIQDIKTENGTCPSPPQPLSP 242

  Fly   190 IESLMAPDPASTPNEGLVPMEYGSPDAVAL-----EKPPFNLP 227
            ..:|.:...|:.|       :..|||:.:.     ..||.:||
Human   243 AAALGSGSAAAVP-------KIESPDSSSSSLSSGSSPPGSLP 278

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fd96CbNP_524496.1 FH_FOX 1..110 CDD:469596 66/107 (62%)
FOXC1NP_001444.2 Required for transcriptional activation. /evidence=ECO:0000269|PubMed:11782474 1..51
FH_FOXC1 73..165 CDD:410818 57/95 (60%)
Nuclear localization signal 1 (NLS 1). /evidence=ECO:0000269|PubMed:11782474 78..93 11/14 (79%)
Nuclear localization signal 2 (NLS 2). /evidence=ECO:0000269|PubMed:11782474 168..176 6/7 (86%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 173..310 25/132 (19%)
Required for transcriptional inhibition. /evidence=ECO:0000269|PubMed:11782474 215..366 15/71 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 356..387
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 414..465
Required for transcriptional activation. /evidence=ECO:0000269|PubMed:11782474 466..553
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.