DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd96Cb and FOXF2

DIOPT Version :9

Sequence 1:	NP_524496.1	Gene:	fd96Cb / 43011	FlyBaseID:	FBgn0004898	Length:	271	Species:	Drosophila melanogaster
Sequence 2:	NP_001443.1	Gene:	FOXF2 / 2295	HGNCID:	3810	Length:	444	Species:	Homo sapiens

Alignment Length:	323	Identity:	93/323 - (28%)
Similarity:	134/323 - (41%)	Gaps:	84/323 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 QKPPYSYISLTAMAIIHSPQRLLPLSEIYRFIMDQFPFYRKNTQKWQNSLRHNLSFNDCFIKVPR 76
            :|||||||:|..|||..||.:.|.|||||:|:..:|||:|...|.|:||:|||||.|:||||:|:
Human    99 EKPPYSYIALIVMAIQSSPSKRLTLSEIYQFLQARFPFFRGAYQGWKNSVRHNLSLNECFIKLPK 163

  Fly    77 NVTKAGKGSYWTLHPMAFDMFENGSLLRRRKRFRVK------QLEKDISNWKLAAA--------- 126
            .:.:.|||.|||:.|.:..|||.||..||.:.||.|      ...:.:|.....|:
Human   164 GLGRPGKGHYWTIDPASEFMFEEGSFRRRPRGFRRKCQALKPMYHRVVSGLGFGASLLPQGFDFQ 228

  Fly   127 ---------------ANTEMVTHYLDDQLTQMAFADPARHGHVLANASAAQMSP-----YKATPP 171
                           ...:|:....|......:.|.|..|.|    .....|||     |.|:.|
Human   229 APPSAPLGCHSQGGYGGLDMMPAGYDAGAGAPSHAHPHHHHH----HHVPHMSPNPGSTYMASCP 289

  Fly   172 ILP--------------------TTVTQLPARPKRAFTIESLMAPDPASTPNEGLVPMEYGSPDA 216
            : |                    ::.:.:|:.|..|..||   ...|.::|     ...:.||.|
Human   290 V-PAGPGGVGAAGGGGGGDYGPDSSSSPVPSSPAMASAIE---CHSPYTSP-----AAHWSSPGA 345

  Fly   217 VA-LEKPPFNLPFNFNELAAQYQLYFPSFFYNGQY----------GNIPCYQKTPPLFHNGPL 268
            .. |::||...|.:....:|.......|:.....|          ..:|.||     .|:.|:
Human   346 SPYLKQPPALTPSSNPAASAGLHSSMSSYSLEQSYLHQNAREDLSVGLPRYQ-----HHSTPV 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd96Cb	NP_524496.1	FH	13..101	CDD:214627	49/87 (56%)
fd96Cb	NP_524496.1	Alpha_kinase	106..>194	CDD:295997	23/142 (16%)
FOXF2	NP_001443.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..98
		FH	100..188	CDD:214627	49/87 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	256..323		13/71 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..367		8/28 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910