DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd96Cb and FOXK1

DIOPT Version :9

Sequence 1:	NP_524496.1	Gene:	fd96Cb / 43011	FlyBaseID:	FBgn0004898	Length:	271	Species:	Drosophila melanogaster
Sequence 2:	NP_001032242.1	Gene:	FOXK1 / 221937	HGNCID:	23480	Length:	733	Species:	Homo sapiens

Alignment Length:	246	Identity:	69/246 - (28%)
Similarity:	96/246 - (39%)	Gaps:	49/246 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DQKPPYSYISLTAMAIIHSPQRLLPLSEIYRFIMDQFPFYRKNTQKWQNSLRHNLSFNDCFIKVP 75
            :.|||:||..|...||..:..|.|.||.||..|...:|:||...:.||||:|||||.|..|||||
Human   303 ESKPPFSYAQLIVQAISSAQDRQLTLSGIYAHITKHYPYYRTADKGWQNSIRHNLSLNRYFIKVP 367

  Fly    76 RNVTKAGKGSYWTLHPMAFDMFENGSLLRRRKR----FRVKQLEKDISNWKLAAAANTEMVTHYL 136
            |:..:.||||:|.:.|.:.......:..:||:|    ||..                       .
Human   368 RSQEEPGKGSFWRIDPASEAKLVEQAFRKRRQRGVSCFRTP-----------------------F 409

  Fly   137 DDQLTQMAFADPARHGHVLANASAAQMSPYKATPPILPTTVTQLPARPKRAFTIESLMAPDPAST 201
            ....::.|.|.|...|.:...:...|      ||..|....:.:|..|:....:        ||.
Human   410 GPLSSRSAPASPTHPGLMSPRSGGLQ------TPECLSREGSPIPHDPEFGSKL--------ASV 460

  Fly   202 PNEGLVPMEYGSP---DAVALEKPPFNLPFNFNELAAQYQLYFPSFFYNGQ 249
            |.........|||   ..|.:..||     ..:.|.|:...|.|:.....|
Human   461 PEYRYSQSAPGSPVSAQPVIMAVPP-----RPSSLVAKPVAYMPASIVTSQ 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd96Cb	NP_524496.1	FH	13..101	CDD:214627	40/87 (46%)
fd96Cb	NP_524496.1	Alpha_kinase	106..>194	CDD:295997	14/91 (15%)
FOXK1	NP_001032242.1	Interaction with SIN3A and SIN3B. /evidence=ECO:0000250\|UniProtKB:P42128	2..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..79
		Required for interaction with FOXO4 and MEF2C. /evidence=ECO:0000250\|UniProtKB:P42128	95..420		46/139 (33%)
		FHA	<102..204	CDD:224630
		FHA	110..203	CDD:238017
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..306		0/2 (0%)
		Forkhead	305..391	CDD:278670	40/85 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	413..436		5/28 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..733
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940