DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd96Cb and FOXD4L1

DIOPT Version :9

Sequence 1:	NP_524496.1	Gene:	fd96Cb / 43011	FlyBaseID:	FBgn0004898	Length:	271	Species:	Drosophila melanogaster
Sequence 2:	NP_036316.1	Gene:	FOXD4L1 / 200350	HGNCID:	18521	Length:	408	Species:	Homo sapiens

Alignment Length:	277	Identity:	99/277 - (35%)
Similarity:	128/277 - (46%)	Gaps:	67/277 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KPPYSYISLTAMAIIHSPQRLLPLSEIYRFIMDQFPFYRKNTQKWQNSLRHNLSFNDCFIKVPRN 77
            |||||||:|..|||:.||.:.|.||.|..||..:||:||:....||||:|||||.||||:|:||.
Human   107 KPPYSYIALITMAILQSPHKRLTLSGICAFISGRFPYYRRKFPAWQNSIRHNLSLNDCFVKIPRE 171

  Fly    78 VTKAGKGSYWTLHPMAFDMFENGSLLRRRKRFRVKQL---------------EKDISNWK----L 123
            ....|||:||:|.|.:.|||:|||.|||||||:..||               ...:.|.:    |
Human   172 PGHPGKGTYWSLDPASQDMFDNGSFLRRRKRFKRHQLTPGAHLPHPFPLPAAHAALHNPRPGPLL 236

  Fly   124 AAAANTEMVTHYLDDQLTQMAFAD--PAR------HGH----VLANASAAQMSPYK------ATP 170
            .|.|..:.|..         |:.:  |.|      |.|    :|.:|.|...:|.|      |||
Human   237 GAPALPQPVPG---------AYPNTAPGRRPYALLHPHPPRYLLLSAPAYAGAPKKAEGADLATP 292

  Fly   171 PILPTTVTQLPARPKR--------------AFTIESLMAPDPASTPNEGLVPMEYGSPDA---VA 218
            ..||.....|..:|..              :|:|||:|    ......|....:..||.|   ..
Human   293 GTLPVLQPSLGPQPWEEGKGLASPPGGGCISFSIESIM----QGVRGAGTGAAQSLSPTAWSYCP 353

  Fly   219 LEKPPFNLPFNFNELAA 235
            |.:.|.:|..||...||
Human   354 LLQRPSSLSDNFAATAA 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd96Cb	NP_524496.1	FH	13..101	CDD:214627	50/87 (57%)
fd96Cb	NP_524496.1	Alpha_kinase	106..>194	CDD:295997	32/138 (23%)
FOXD4L1	NP_036316.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..104
		Forkhead	107..193	CDD:278670	49/85 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..408
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.870