DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd96Cb and Foxk1

DIOPT Version :9

Sequence 1:	NP_524496.1	Gene:	fd96Cb / 43011	FlyBaseID:	FBgn0004898	Length:	271	Species:	Drosophila melanogaster
Sequence 2:	NP_951031.2	Gene:	Foxk1 / 17425	MGIID:	1347488	Length:	719	Species:	Mus musculus

Alignment Length:	246	Identity:	73/246 - (29%)
Similarity:	97/246 - (39%)	Gaps:	49/246 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DQKPPYSYISLTAMAIIHSPQRLLPLSEIYRFIMDQFPFYRKNTQKWQNSLRHNLSFNDCFIKVP 75
            :.||||||..|...||..:..|.|.||.||..|...:|:||...:.||||:|||||.|..|||||
Mouse   289 ESKPPYSYAQLIVQAISSAQDRQLTLSGIYAHITKHYPYYRTADKGWQNSIRHNLSLNRYFIKVP 353

  Fly    76 RNVTKAGKGSYWTLHPMAFDMFENGSLLRRRKR----FRVKQLEKDISNWKLAAAANTEMVTHYL 136
            |:..:.||||:|.:.|.:.......:..:||:|    ||..                       .
Mouse   354 RSQEEPGKGSFWRIDPASEAKLVEQAFRKRRQRGVSCFRTP-----------------------F 395

  Fly   137 DDQLTQMAFADPARHGHVLANASAAQMSPYKATPPILPTTVTQLPARPKRAFTIESLMAPDPAST 201
            ....::.|.|.|...|.:...:|..|      ||..|....:.:|..|.        :....||.
Mouse   396 GPLSSRSAPASPTHPGLMSPRSSGLQ------TPECLSREGSPIPHDPD--------LGSKLASV 446

  Fly   202 PNEGLVPMEYGSP---DAVALEKPPFNLPFNFNELAAQYQLYFPSFFYNGQ 249
            |.........|||   ..|.:..||  .|.|   |.|:...|.|:.....|
Mouse   447 PEYRYSQSAPGSPVSAQPVIMAVPP--RPSN---LVAKPVAYMPASIVTSQ 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd96Cb	NP_524496.1	FH	13..101	CDD:214627	41/87 (47%)
fd96Cb	NP_524496.1	Alpha_kinase	106..>194	CDD:295997	15/91 (16%)
Foxk1	NP_951031.2	Interaction with SIN3A and SIN3B. /evidence=ECO:0000269\|PubMed:10620510, ECO:0000269\|PubMed:22476904	2..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..67
		Required for interaction with FOXO4 and MEF2C. /evidence=ECO:0000269\|PubMed:22956541	81..406		47/139 (34%)
		FHA	<88..190	CDD:224630
		FHA	96..189	CDD:238017
		Forkhead	291..377	CDD:278670	41/85 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..443		11/57 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	665..719
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940