DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd96Cb and Foxb2

DIOPT Version :9

Sequence 1:	NP_524496.1	Gene:	fd96Cb / 43011	FlyBaseID:	FBgn0004898	Length:	271	Species:	Drosophila melanogaster
Sequence 2:	NP_032049.1	Gene:	Foxb2 / 14240	MGIID:	1347468	Length:	428	Species:	Mus musculus

Alignment Length:	240	Identity:	106/240 - (44%)
Similarity:	131/240 - (54%)	Gaps:	26/240 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPRPLKMSYGDQKPPYSYISLTAMAIIHSPQRLLPLSEIYRFIMDQFPFYRKNTQKWQNSLRHNL 65
            ||||.|.||.||||||||||||||||.||.:::||||:||:|||::||:||::||:|||||||||
Mouse     1 MPRPGKSSYSDQKPPYSYISLTAMAIQHSAEKMLPLSDIYKFIMERFPYYREHTQRWQNSLRHNL 65

  Fly    66 SFNDCFIKVPRNVTKAGKGSYWTLHPMAFDMFENGSLLRRRKRFRV-----KQLEKDISNWKLAA 125
            ||||||||:||...:.||||:|.|||...|||||||.|||||||:|     ..|....|......
Mouse    66 SFNDCFIKIPRRPDQPGKGSFWALHPDCGDMFENGSFLRRRKRFKVLRADHAHLHSGSSKGAPGT 130

  Fly   126 AANTEMVTHYLDDQLTQMAFADPARHGHVLANASAAQMSPYKATPPILPTTVTQLPARPKRAFTI 190
            .....:..|:       ...|....|.|..|........|.:..||..|..|.....:|
Mouse   131 GPGGHLHPHH-------PHHAHHHHHHHHHAAHHHHHHHPPQPPPPPPPHMVPYFHQQP------ 182

  Fly   191 ESLMAPDPASTPNEGLVPMEYGSPDAVALEKPPFNLPFNFNELAA 235
              ..||.|...|::   |.:...|.:   :.|..:.|....|.||
Mouse   183 --APAPQPPHLPSQ---PAQQPQPQS---QPPQTSHPGKMQEAAA 219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd96Cb	NP_524496.1	FH	13..101	CDD:214627	63/87 (72%)
fd96Cb	NP_524496.1	Alpha_kinase	106..>194	CDD:295997	18/92 (20%)
Foxb2	NP_032049.1	FH	13..101	CDD:214627	63/87 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..217		21/119 (18%)
		E_Pc_C	<342..>406	CDD:284226
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..428
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG3562
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3895
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1236900at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	1	1.000	-	-		mtm8816
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.900