DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd96Ca and FOXL2

DIOPT Version :9

Sequence 1:	NP_001287516.1	Gene:	fd96Ca / 43010	FlyBaseID:	FBgn0004897	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_075555.1	Gene:	FOXL2 / 668	HGNCID:	1092	Length:	376	Species:	Homo sapiens

Alignment Length:	400	Identity:	114/400 - (28%)
Similarity:	155/400 - (38%)	Gaps:	140/400 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PRPSRESYGEQKPPYSYISLTAMAIWSSPEKMLPLSDIYKFITDRFPYYRKNTQRWQNSLRHNLS 66
            |.|:      |||||||::|.||||..|.||.|.||.||::|..:||:|.||.:.||||:|||||
Human    49 PDPA------QKPPYSYVALIAMAIRESAEKRLTLSGIYQYIIAKFPFYEKNKKGWQNSIRHNLS 107

  Fly    67 FNDCFIKVPRRPDRPGKGAYWALHPQAFDMFENGSLLRRRKRFK-------LH-KNDKDLLNEEL 123
            .|:|||||||......||.||.|.|...||||.|: .|||:|.|       .| :..|.|...
Human   108 LNECFIKVPREGGGERKGNYWTLDPACEDMFEKGN-YRRRRRMKRPFRPPPAHFQPGKGLFGA-- 169

  Fly   124 TALANLNRFFFTTRNGGSA-------------AHMSPLD------MNNAAAMRLDPLPRSTAHMP 169
                           ||:|             .:::|..      :||:.     |||:..:.||
Human   170 ---------------GGAAGGCGVAGAGADGYGYLAPPKYLQSGFLNNSW-----PLPQPPSPMP 214

  Fly   170 -----------------NSLGPGVPLPHVMPASMSG-----ADHTNLADMGLTNLPALTSS--EI 210
                             .:.|||.|....:...::|     ..:|.:..|.|.  |.:.:|  .:
Human   215 YASCQMAAAAAAAAAAAAAAGPGSPGAAAVVKGLAGPAASYGPYTRVQSMALP--PGVVNSYNGL 277

  Fly   211 EGPLSLRPKRSFTIESLITPDKPEHPSEDEDDEDDRVDIDVVECSGISRYPTTPAASEEYMSASR 275
            .||.:             .|..|.||                       :| .|.|...:.:|:
Human   278 GGPPA-------------APPPPPHP-----------------------HP-HPHAHHLHAAAA- 304

  Fly   276 SSRTEDPLPPMHTINAGAHVPFLHYATGANVAGLPASGIPNSPTTYELAISHPLFMMAA----PI 336
                ..|.||.|    ||..|    ..|......||:..|.:|.    ..|.|....|.    .:
Human   305 ----PPPAPPHH----GAAAP----PPGQLSPASPATAAPPAPA----PTSAPGLQFACARQPEL 353

  Fly   337 ANMHNIYYNN 346
            |.||..|:::
Human   354 AMMHCSYWDH 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd96Ca	NP_001287516.1	FH	13..101	CDD:214627	52/87 (60%)
FOXL2	NP_075555.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		2/9 (22%)
		Forkhead	53..139	CDD:365978	51/85 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	276..342		23/119 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910