DRSC/TRiP Functional Genomics Resources

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Protein Alignment fd96Ca and Foxo1

DIOPT Version :10

Sequence 1:NP_524495.1 Gene:fd96Ca / 43010 FlyBaseID:FBgn0004897 Length:372 Species:Drosophila melanogaster
Sequence 2:NP_062713.2 Gene:Foxo1 / 56458 MGIID:1890077 Length:652 Species:Mus musculus


Alignment Length:449 Identity:101/449 - (22%)
Similarity:165/449 - (36%) Gaps:140/449 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 PRPSRESYGEQKPPYSYISLTAMAIWSSPEKMLPLSDIYKFITDRFPYYR-----KNTQRWQNSL 61
            ||.:..|........||..|...||.||.||.|.||.||:::....||::     .::..|:||:
Mouse   146 PRKTSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSI 210

  Fly    62 RHNLSFNDCFIKVPRRPDRPGKGAYWALHPQAFDMFENGSLLRRRKRFKLHKNDKDLLNEELTA- 125
            |||||.:..||:|  :.:..||.::|.|:|:.   .::|...|||.. .:..|.|...:....| 
Mouse   211 RHNLSLHSKFIRV--QNEGTGKSSWWMLNPEG---GKSGKSPRRRAA-SMDNNSKFAKSRGRAAK 269

  Fly   126 -LANL------------NRFFFTTRNGGSAAH--------MSPLDMNNAAAM--RLDPL------ 161
             .|:|            ::|.....:.||.::        ..|...:||:.:  ||.|:      
Mouse   270 KKASLQSGQEGPGDSPGSQFSKWPASPGSHSNDDFDNWSTFRPRTSSNASTISGRLSPIMTEQDD 334

  Fly   162 -----------PRSTAHMPNSLGPGVPLPHVM----PASMSG-ADHTNLADMGLTNLPALTSSEI 210
                       |.|.|.|.::      ||.:.    |.:|.. .|:.||    |::..:||.|..
Mouse   335 LGDGDVHSLVYPPSAAKMAST------LPSLSEISNPENMENLLDNLNL----LSSPTSLTVSTQ 389

  Fly   211 EGPLSL---RPKRSFT--IESLITPDK---------------PEHPSEDEDDEDDRVDIDVVECS 255
            ..|.|:   .|..||.  ..||.:|..               |:.|.:...|...       ...
Mouse   390 SSPGSMMQQTPCYSFAPPNTSLNSPSPNYSKYTYGQSSMSPLPQMPMQTLQDSKS-------SYG 447

  Fly   256 GISRYPTTPAASEEYMSASRSSRTE--DPLPP-----------------------------MHT- 288
            |:::|...|...:|.:::......:  .|:.|                             .|. 
Mouse   448 GLNQYNCAPGLLKELLTSDSPPHNDIMSPVDPGVAQPNSRVLGQNVMMGPNSVMPAYGSQASHNK 512

  Fly   289 -INAGAHVPFLHYATGANVAG--LP--ASGIPNS---------PTTYELAISHPLFMMA 333
             :|..:|....|....|:|.|  ||  .:.:|::         .|..::.:|||:.|.|
Mouse   513 MMNPSSHTHPGHAQQTASVNGRTLPHVVNTMPHTSAMNRLTPVKTPLQVPLSHPMQMSA 571

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fd96CaNP_524495.1 FH_FOX 1..110 CDD:469596 39/112 (35%)
Foxo1NP_062713.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..62
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..154 3/7 (43%)
FH_FOXO1 148..246 CDD:410834 34/102 (33%)
DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778 208..215 5/6 (83%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..342 21/114 (18%)
DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778 231..234 0/2 (0%)
Nuclear localization signal. /evidence=ECO:0000250 248..250 1/1 (100%)
Sufficient for interaction with NLK. /evidence=ECO:0000269|PubMed:20061393 280..562 52/298 (17%)
Required for interaction with RUNX2. /evidence=ECO:0000269|PubMed:21471200 360..456 22/106 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 383..410 8/26 (31%)
FOXO_KIX_bdg 420..501 CDD:465228 9/87 (10%)
Required for interaction with SIRT1. /evidence=ECO:0000269|PubMed:15220471 459..463 1/3 (33%)
FOXO-TAD 594..630 CDD:435506
Blue background indicates that the domain is not in the aligned region.

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