Protein Alignment fd96Ca and FOXO4

DIOPT Version :10

• Sequence 1: NP_524495.1
• Gene: fd96Ca / 43010
• FlyBaseID: FBgn0004897
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_005929.2
• Gene: FOXO4 / 4303
• HGNCID: 7139
• Length: 505
• Species: Homo sapiens
• Alignment Length: 435
• Identity: 110/435 - (25%)
• Similarity: 165/435 - (37%)
• Gaps: 129/435 - (29%)

  Fly     6 RESYGEQKPPYSYISLTAMAIWSSPEKMLPLSDIYKFITDRFPYYR-----KNTQRWQNSLRHNL 65
            |.::|.|    ||..|.:.||.|:|||.|.|:.||:::....||::     .::..|:||:||||
Human    98 RNAWGNQ----SYAELISQAIESAPEKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNL 158

  Fly    66 SFNDCFIKVPRRPDRPGKGAYWALHPQ-----------AFDMFENGSLLRRRKRFKLHKNDKDLL 119
            |.:..||||  ..:..||.::|.|:|:           |..|..:..|||.|.  |..|....:|
Human   159 SLHSKFIKV--HNEATGKSSWWMLNPEGGKSGKAPRRRAASMDSSSKLLRGRS--KAPKKKPSVL 219

  Fly   120 ---NEELTALANLNRFFF-----TTRNGGSA---AHMSPLDMNNAAAM--RLDPL-PRS---TAH 167
               .|..|..:.:..|..     .:||...|   ....|...:||:::  ||.|| |.|   ...
Human   220 PAPPEGATPTSPVGHFAKWSGSPCSRNREEADMWTTFRPRSSSNASSVSTRLSPLRPESEVLAEE 284

  Fly   168 MP---NSLGPGVPLPHVMPASMSG----------ADHTNLADMGLTNL----PALTS-------- 207
            :|   :|...|||     |....|          :.|:.|:..||:..    |.:|.
Human   285 IPASVSSYAGGVP-----PTLNEGLELLDGLNLTSSHSLLSRSGLSGFSLQHPGVTGPLHTYSSS 344

  Fly   208 --SEIEGPLSLRP---KRSFTIESLITPDKPEHPSEDEDDEDDRVDIDVVECSGISRYPT----- 262
              |..|||||...   ..|..:|:|:|.|.|..|::....:.|.:         :|:.||
Human   345 LFSPAEGPLSAGEGCFSSSQALEALLTSDTPPPPADVLMTQVDPI---------LSQAPTLLLLG 400

  Fly   263 -TPAASEEYMSASRSSRTEDPLPPMHTINAGAHVPFLHYATGANVAGLP--ASGIPNSPTTYELA 324
             .|::|:                               .|||..:...|  |.| |:|.......
Human   401 GLPSSSK-------------------------------LATGVGLCPKPLEAPG-PSSLVPTLSM 433

  Fly   325 ISHPLFMMAAPIANMHNIYYNNVTLVAPAQQYRSPEVQNRIDNDM 369
            |:.|..|.:|||...    .....|..|.:......:...:|.||
Human   434 IAPPPVMASAPIPKA----LGTPVLTPPTEAASQDRMPQDLDLDM 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fd96Ca	NP_524495.1	FH_FOX	1..110	CDD:469596	41/119 (34%)
FOXO4	NP_005929.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100		1/1 (100%)
		FH_FOXO4	98..183	CDD:410836	34/90 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	176..246		15/71 (21%)
		FOXO_KIX_bdg	<358..393	CDD:465228	9/43 (21%)
		FOXO-TAD	465..503	CDD:435506	3/10 (30%)