DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd96Ca and FOXA2

DIOPT Version :9

Sequence 1:	NP_001287516.1	Gene:	fd96Ca / 43010	FlyBaseID:	FBgn0004897	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_068556.2	Gene:	FOXA2 / 3170	HGNCID:	5022	Length:	463	Species:	Homo sapiens

Alignment Length:	350	Identity:	119/350 - (34%)
Similarity:	162/350 - (46%)	Gaps:	66/350 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PRPSRESYGEQKPPYSYISLTAMAIWSSPEKMLPLSDIYKFITDRFPYYRKNTQRWQNSLRHNLS 66
            |:..|.||...|||||||||..|||..||.|||.||:||::|.|.||:||:|.||||||:||:||
Human   154 PKTYRRSYTHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLS 218

  Fly    67 FNDCFIKVPRRPDRPGKGAYWALHPQAFDMFENGSLLRRRKRFKLHKNDKDLLNEELTALANLNR 131
            |||||:||||.||:||||::|.|||.:.:|||||..|||:||||.   :|.|..:|....|.
Human   219 FNDCFLKVPRSPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKC---EKQLALKEAAGAAG--- 277

  Fly   132 FFFTTRNGGSAAHMSPLDMNNAAAMRLD-----PLPRSTA-----HMPNSLG-----PGVPLPHV 181
               :.:...:.|..|...:..||....:     ..|.|:|     |....||     |...|...
Human   278 ---SGKKAAAGAQASQAQLGEAAGPASETPAGTESPHSSASPCQEHKRGGLGELKGTPAAALSPP 339

  Fly   182 MPASMSGADHTNLAD-MGLTNLPALTSSEIEGPLSLRPK------RSFTIESLITPDKPEHPSED 239
            .||...|......|. :|..:.|.|...     ..|:|:      ..|:|.:|::.::..|.|.
Human   340 EPAPSPGQQQQAAAHLLGPPHHPGLPPE-----AHLKPEHHYAFNHPFSINNLMSSEQQHHHSH- 398

  Fly   240 EDDEDDRVDIDVVECSGISRYPTTPAASEEYMSASRSSRTEDPLPPMHTINAGAHVPFLHYATGA 304
            ...:..::|:...|  .:..||       .|.|....|....|:                    .
Human   399 HHHQPHKMDLKAYE--QVMHYP-------GYGSPMPGSLAMGPV--------------------T 434

  Fly   305 NVAGLPASGIPNSPTTYELAISHPL 329
            |..||.||.:....:.|:...|.|:
Human   435 NKTGLDASPLAADTSYYQGVYSRPI 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd96Ca	NP_001287516.1	FH	13..101	CDD:214627	61/87 (70%)
FOXA2	NP_068556.2	Forkhead_N	23..164	CDD:369872	4/9 (44%)
		FH_FOXA2	163..264	CDD:410813	69/103 (67%)
		HNF_C	380..452	CDD:401339	18/101 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910