DRSC/TRiP Functional Genomics Resources

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Protein Alignment fd96Ca and FOXO3

DIOPT Version :10

Sequence 1:NP_524495.1 Gene:fd96Ca / 43010 FlyBaseID:FBgn0004897 Length:372 Species:Drosophila melanogaster
Sequence 2:NP_001446.1 Gene:FOXO3 / 2309 HGNCID:3821 Length:673 Species:Homo sapiens


Alignment Length:396 Identity:88/396 - (22%)
Similarity:148/396 - (37%) Gaps:105/396 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 RESYGEQKPPYSYISLTAMAIWSSPEKMLPLSDIYKFITDRFPYYR-----KNTQRWQNSLRHNL 65
            |.::|.    .||..|...||.|||:|.|.||.||:::....||::     .::..|:||:||||
Human   154 RNAWGN----LSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNL 214

  Fly    66 SFNDCFIKVPRRPDRPGKGAYWALHPQAFDMFENGSLLRRRKRFKLHKNDKDLLNEELTALANLN 130
            |.:..|::|  :.:..||.::|.::|   |..::|...|||                ..::.|.|
Human   215 SLHSRFMRV--QNEGTGKSSWWIINP---DGGKSGKAPRRR----------------AVSMDNSN 258

  Fly   131 RFFFTTRNGGSAAHMSPLDMNNAAAMRLDPLPRSTAHMPNSLG--PGVPLPHVMPASMSGAD--- 190
            ::   |::.|.||       ...||  |...|.|....|:.|.  ||.|.........:..|   
Human   259 KY---TKSRGRAA-------KKKAA--LQTAPESADDSPSQLSKWPGSPTSRSSDELDAWTDFRS 311

  Fly   191 --HTNLADMGLTNLPALTSSEI------EGPLS--LRPKRSFTIESLITPDKPEHP--------- 236
              ::|.:.:.....|.:.|:|:      :.|||  |....:....|:..|...|.|         
Human   312 RTNSNASTVSGRLSPIMASTELDEVQDDDAPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTM 376

  Fly   237 ----SEDEDDEDDRVDIDVVECSGISRYPTTPAASEEYMSASRSSRTEDPLPPMHTINAGAHVPF 297
                ...|:..||.:|       .|:..|:.|:.:...|..|.|                     
Human   377 NLNDGLTENLMDDLLD-------NITLPPSQPSPTGGLMQRSSS--------------------- 413

  Fly   298 LHYATGANVAGLPASGIPNSPTTYELAISHPLFMMAAPIANMHNIYYNNVTLVAPAQQYRSPEVQ 362
            ..|.|..:..|.|.|       ::...:..|..:.:...:.|..|..|.....:....|.:..:|
Human   414 FPYTTKGSGLGSPTS-------SFNSTVFGPSSLNSLRQSPMQTIQENKPATFSSMSHYGNQTLQ 471

  Fly   363 NRIDND 368
            :.:.:|
Human   472 DLLTSD 477

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fd96CaNP_524495.1 FH_FOX 1..110 CDD:469596 37/108 (34%)
FOXO3NP_001446.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..153
Required for mitochondrial import. /evidence=ECO:0000269|PubMed:23283301 80..108
FH_FOXO3 157..239 CDD:410835 31/90 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..302 23/101 (23%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:17940099, ECO:0000269|PubMed:29445193 242..259 5/32 (16%)
Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000269|PubMed:15084260 300..673 35/213 (16%)
FOXO_KIX_bdg 432..511 CDD:465228 7/46 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 536..587
FOXO-TAD 606..644 CDD:435506
Blue background indicates that the domain is not in the aligned region.

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