DRSC/TRiP Functional Genomics Resources

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Protein Alignment fd96Ca and FOXO1

DIOPT Version :10

Sequence 1:NP_524495.1 Gene:fd96Ca / 43010 FlyBaseID:FBgn0004897 Length:372 Species:Drosophila melanogaster
Sequence 2:NP_002006.2 Gene:FOXO1 / 2308 HGNCID:3819 Length:655 Species:Homo sapiens


Alignment Length:412 Identity:99/412 - (24%)
Similarity:152/412 - (36%) Gaps:109/412 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 PRPSRESYGEQKPPYSYISLTAMAIWSSPEKMLPLSDIYKFITDRFPYYR-----KNTQRWQNSL 61
            ||.|..|........||..|...||.||.||.|.||.||:::....||::     .::..|:||:
Human   149 PRKSSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSI 213

  Fly    62 RHNLSFNDCFIKVPRRPDRPGKGAYWALHPQ-----------AFDMFENGSLLRRRKRFKLHKND 115
            |||||.:..||:|  :.:..||.::|.|:|:           |..|..|....:.|.|....|..
Human   214 RHNLSLHSKFIRV--QNEGTGKSSWWMLNPEGGKSGKSPRRRAASMDNNSKFAKSRSRAAKKKAS 276

  Fly   116 KDLLNEELTALANLNRFFFTTRNGGSAAH--------MSPLDMNNAAAM--RLDPL--------- 161
            .. ..:|....:..::|.....:.||.::        ..|...:||:.:  ||.|:         
Human   277 LQ-SGQEGAGDSPGSQFSKWPASPGSHSNDDFDNWSTFRPRTSSNASTISGRLSPIMTEQDDLGE 340

  Fly   162 --------PRSTAHMPNSLGPGVPLPHVM----PASMSG-ADHTNLADMGLTNLPALTSSEIEGP 213
                    |.|.|.|.::      ||.:.    |.:|.. .|:.||    |::..:||.|....|
Human   341 GDVHSMVYPPSAAKMAST------LPSLSEISNPENMENLLDNLNL----LSSPTSLTVSTQSSP 395

  Fly   214 ---LSLRPKRSFT--IESLITPDK---------------PEHPSEDEDDEDDRVDIDVVECSGIS 258
               :...|..||.  ..||.:|..               |:.|.:...|...       ...|:|
Human   396 GTMMQQTPCYSFAPPNTSLNSPSPNYQKYTYGQSSMSPLPQMPIQTLQDNKS-------SYGGMS 453

  Fly   259 RYPTTPAASEEYMSASRSSRTEDPLPP----MHTINAGAHVPFLHYATGANVAGLPASGIPNS-P 318
            :|...|...:|.:::..        ||    |..::.|...|      .:.|.|......||| .
Human   454 QYNCAPGLLKELLTSDS--------PPHNDIMTPVDPGVAQP------NSRVLGQNVMMGPNSVM 504

  Fly   319 TTYELAISHPLFMMAAPIANMH 340
            :||....||.  .|..|.::.|
Human   505 STYGSQASHN--KMMNPSSHTH 524

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fd96CaNP_524495.1 FH_FOX 1..110 CDD:469596 41/123 (33%)
FOXO1NP_002006.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..63
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 116..158 4/8 (50%)
FH_FOXO1 151..249 CDD:410834 34/99 (34%)
DNA-binding. /evidence=ECO:0000269|PubMed:18786403 211..218 5/6 (83%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 234..344 19/110 (17%)
DNA-binding. /evidence=ECO:0000269|PubMed:18786403 234..237 0/2 (0%)
Nuclear localization signal 251..253 0/1 (0%)
Sufficient for interaction with NLK. /evidence=ECO:0000250|UniProtKB:Q9R1E0 283..563 56/275 (20%)
Required for interaction with RUNX2. /evidence=ECO:0000250|UniProtKB:Q9R1E0 363..459 22/106 (21%)
FOXO_KIX_bdg 423..504 CDD:465228 18/101 (18%)
Required for interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:Q9R1E0 462..466 1/3 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 507..537 6/20 (30%)
FOXO-TAD 597..633 CDD:435506
Blue background indicates that the domain is not in the aligned region.

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