DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd96Ca and FOXD2

DIOPT Version :9

Sequence 1:	NP_001287516.1	Gene:	fd96Ca / 43010	FlyBaseID:	FBgn0004897	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_004465.3	Gene:	FOXD2 / 2306	HGNCID:	3803	Length:	495	Species:	Homo sapiens

Alignment Length:	286	Identity:	105/286 - (36%)
Similarity:	125/286 - (43%)	Gaps:	69/286 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PRPSRESYGEQ------KPPYSYISLTAMAIWSSPEKMLPLSDIYKFITDRFPYYRKNTQRWQNS 60
            |.|...|.|..      |||||||:|..|||..||:|.|.||:|.:||:.||||||:....||||
Human   110 PGPGPPSGGAATRSPLVKPPYSYIALITMAILQSPKKRLTLSEICEFISGRFPYYREKFPAWQNS 174

  Fly    61 LRHNLSFNDCFIKVPRRPDRPGKGAYWALHPQAFDMFENGSLLRRRKRFKL----------HKND 115
            :|||||.||||:|:||.|..||||.||.|.|::.|||:|||.||||||||.          |.:.
Human   175 IRHNLSLNDCFVKIPREPGNPGKGNYWTLDPESADMFDNGSFLRRRKRFKRQPLPPPHPHPHPHP 239

  Fly   116 KDLLNEELTALANLNRFF-------------------FTTRNGGSAAHMSP-------LDMNNAA 154
            :.||.....|..:...|.                   :.....|.|.|..|       .....||
Human   240 ELLLRGGAAAAGDPGAFLPGFAAYGAYGYGYGLALPAYGAPPPGPAPHPHPHPHAFAFAAAAAAA 304

  Fly   155 AMRLDPLPRSTAHMPNSLGPGVP----------LPHVMPASMSGADHTNLADMGLTNLPALTSSE 209
            ..:|...|...|..|    ||.|          .|...|||.||      ...|...|||...:|
Human   305 PCQLSVPPGRAAAPP----PGPPTASVFAGAGSAPAPAPASGSG------PGPGPAGLPAFLGAE 359

  Fly   210 IEG------PLSLRPKRSFTIESLIT 229
            : |      ..||.|..:.|...|.|
Human   360 L-GCAKAFYAASLSPPAAGTAAGLPT 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd96Ca	NP_001287516.1	FH	13..101	CDD:214627	55/87 (63%)
FOXD2	NP_004465.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..122		4/11 (36%)
		Forkhead	127..213	CDD:278670	54/85 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..347		12/44 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..444
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910