DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd96Ca and FOXK1

DIOPT Version :9

Sequence 1:	NP_001287516.1	Gene:	fd96Ca / 43010	FlyBaseID:	FBgn0004897	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_001032242.1	Gene:	FOXK1 / 221937	HGNCID:	23480	Length:	733	Species:	Homo sapiens

Alignment Length:	378	Identity:	106/378 - (28%)
Similarity:	143/378 - (37%)	Gaps:	108/378 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 EQKPPYSYISLTAMAIWSSPEKMLPLSDIYKFITDRFPYYRKNTQRWQNSLRHNLSFNDCFIKVP 75
            |.|||:||..|...||.|:.::.|.||.||..||..:||||...:.||||:|||||.|..|||||
Human   303 ESKPPFSYAQLIVQAISSAQDRQLTLSGIYAHITKHYPYYRTADKGWQNSIRHNLSLNRYFIKVP 367

  Fly    76 RRPDRPGKGAYWALHPQAFDMFENGSLLRRRKRFKLHKNDKDLLNEELTALANLNRFFFTTRNGG 140
            |..:.||||::|.:.|.:.......:..:||:|                     ....|.|..|
Human   368 RSQEEPGKGSFWRIDPASEAKLVEQAFRKRRQR---------------------GVSCFRTPFG- 410

  Fly   141 SAAHMSPLDMNNAAAMRLDP---LPRSTA-HMPNSLG-PGVPLPH------------------VM 182
                  ||...:|.|....|   .|||.. ..|..|. .|.|:||                  ..
Human   411 ------PLSSRSAPASPTHPGLMSPRSGGLQTPECLSREGSPIPHDPEFGSKLASVPEYRYSQSA 469

  Fly   183 PASMSGADHTNLADMGLTNLPALTSSEIEGPLSLRPKRSFTIESLITPDKPEHPSEDEDDEDDRV 247
            |.|...|....:|      :|...||.:..|::..|      .|::|..:|...:
Human   470 PGSPVSAQPVIMA------VPPRPSSLVAKPVAYMP------ASIVTSQQPAGHA---------- 512

  Fly   248 DIDVVECS---GISRYPTTPAASEE-YMSASRSSRTEDPLPPMHTINAGAHVPFLHYATGANV-- 306
             |.||:.:   .:.|..||.|.|.. |:..|:.:             ||..    |.|.||.|
Human   513 -IHVVQQAPTVTMVRVVTTSANSANGYILTSQGA-------------AGGS----HDAAGAAVLD 559

  Fly   307 AGLPASGIPNSPT----TYELA--ISHPLFMMAAPIANMHNIYYNNVTLVAPA 353
            .|..|.|:...||    |...|  :...:....||....|     .||::.||
Human   560 LGSEARGLEEKPTIAFATIPAAGGVIQTVASQMAPGVPGH-----TVTILQPA 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd96Ca	NP_001287516.1	FH	13..101	CDD:214627	42/87 (48%)
FOXK1	NP_001032242.1	Interaction with SIN3A and SIN3B. /evidence=ECO:0000250\|UniProtKB:P42128	2..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..79
		Required for interaction with FOXO4 and MEF2C. /evidence=ECO:0000250\|UniProtKB:P42128	95..420		52/144 (36%)
		FHA	<102..204	CDD:224630
		FHA	110..203	CDD:238017
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..306		1/2 (50%)
		Forkhead	305..391	CDD:278670	42/85 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	413..436		6/22 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..733
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940