DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fd96Ca and Foxk1

DIOPT Version :9

Sequence 1:	NP_001287516.1	Gene:	fd96Ca / 43010	FlyBaseID:	FBgn0004897	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_951031.2	Gene:	Foxk1 / 17425	MGIID:	1347488	Length:	719	Species:	Mus musculus

Alignment Length:	410	Identity:	103/410 - (25%)
Similarity:	151/410 - (36%)	Gaps:	116/410 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 EQKPPYSYISLTAMAIWSSPEKMLPLSDIYKFITDRFPYYRKNTQRWQNSLRHNLSFNDCFIKVP 75
            |.||||||..|...||.|:.::.|.||.||..||..:||||...:.||||:|||||.|..|||||
Mouse   289 ESKPPYSYAQLIVQAISSAQDRQLTLSGIYAHITKHYPYYRTADKGWQNSIRHNLSLNRYFIKVP 353

  Fly    76 RRPDRPGKGAYWALHPQAFDMFENGSLLRRRKR----FK---------------LH--------- 112
            |..:.||||::|.:.|.:.......:..:||:|    |:               .|
Mouse   354 RSQEEPGKGSFWRIDPASEAKLVEQAFRKRRQRGVSCFRTPFGPLSSRSAPASPTHPGLMSPRSS 418

  Fly   113 ---------------KNDKDLLNEELTALANLNRFFFTTRNGGSAAHMSPLDMNNAAAMRLDPLP 162
                           .:|.||.::    ||::..:.::....||.....|:      .|.:.|.|
Mouse   419 GLQTPECLSREGSPIPHDPDLGSK----LASVPEYRYSQSAPGSPVSAQPV------IMAVPPRP 473

  Fly   163 -----RSTAHMPNSL----------------GPGVPLPHVMPASMSGADHTNLADMGLTNLPALT 206
                 :..|:||.|:                .|.|.:..|:..|.:.|:...||..|.|.    |
Mouse   474 SNLVAKPVAYMPASIVTSQQPSGHAIHVVQQAPTVTMVRVVTTSANSANGYILASQGSTG----T 534

  Fly   207 SSEIEGP-----------LSLRPKRSF-----------TIESLITPDKPEH------PSEDEDDE 243
            |.:..|.           |..:|..:|           |:.|.:.|..|.|      |:......
Mouse   535 SHDTAGTAVLDLGNEARGLEEKPTIAFATIPAASRVIQTVASQMAPGVPGHTVTILQPATPVTIG 599

  Fly   244 DDRVDIDVVECSGISRYPTTPAASEEY--------MSASRSSRTEDPLPPMHTINAGAHVPFLHY 300
            ...:.:..|..:|....||.......|        ::|..||.|  |:........|...|....
Mouse   600 QHHLPVRAVTQNGKHAVPTNSLTGNAYALSSPLQLLAAQASSST--PVVITRVCEVGPEEPAAAV 662

  Fly   301 ATGANVAGLPASGIPNSPTT 320
            :..||.|..||:....|.::
Mouse   663 SVAANAAPTPAASTTTSASS 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd96Ca	NP_001287516.1	FH	13..101	CDD:214627	43/87 (49%)
Foxk1	NP_951031.2	Interaction with SIN3A and SIN3B. /evidence=ECO:0000269\|PubMed:10620510, ECO:0000269\|PubMed:22476904	2..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..67
		Required for interaction with FOXO4 and MEF2C. /evidence=ECO:0000269\|PubMed:22956541	81..406		48/116 (41%)
		FHA	<88..190	CDD:224630
		FHA	96..189	CDD:238017
		Forkhead	291..377	CDD:278670	43/85 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..443		4/47 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	665..719		6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940