DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd96Ca and Foxc1

DIOPT Version :9

Sequence 1:	NP_001287516.1	Gene:	fd96Ca / 43010	FlyBaseID:	FBgn0004897	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_032618.2	Gene:	Foxc1 / 17300	MGIID:	1347466	Length:	553	Species:	Mus musculus

Alignment Length:	401	Identity:	118/401 - (29%)
Similarity:	155/401 - (38%)	Gaps:	118/401 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPRP----SRESYGEQ----------------------KPPYSYISLTAMAIWSSPEKMLPLSDI 39
            ||.|    |..::.||                      |||||||:|..|||.::|:|.:.|:.|
Mouse    40 MPAPMSVYSHPAHAEQYPGSMARAYGPYTPQPQPKDMVKPPYSYIALITMAIQNAPDKKITLNGI 104

  Fly    40 YKFITDRFPYYRKNTQRWQNSLRHNLSFNDCFIKVPRRPDRPGKGAYWALHPQAFDMFENGSLLR 104
            |:||.||||:||.|.|.||||:|||||.|:||:||||...:||||:||.|.|.:::||||||.||
Mouse   105 YQFIMDRFPFYRDNKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLR 169

  Fly   105 RRKRFKLHKNDKDLLNEELTALANLNRFFFTTRNGGSAAHMSPLDMNNAAAMRLDPLPRSTAHMP 169
            ||:|||.....||  .||...|                 |:.            :|.|......|
Mouse   170 RRRRFKKKDAVKD--KEEKGRL-----------------HLQ------------EPPPPQAGRQP 203

  Fly   170 NSLGP-----GVPLPHVMPASMSGADHTNLADMGLTNLPALTSSEIEGPLSLRPKRSFTIESLIT 229
            ....|     ..|.|...|..:......|    |....|         |..|.|..:....|..|
Mouse   204 APAPPEQAEGSAPGPQPPPVRIQDIKTEN----GTCPSP---------PQPLSPAAALGSGSAAT 255

  Fly   230 PDKPEHPSEDEDDEDDRVDIDVVECSGISRYPTTPAASEEYMSASRSSRTEDPLPPMHTINAGAH 294
            ..|.|.|........          ||.|...:.|:|....:.|:..:....|.||.
Mouse   256 VPKIESPDSSSSSLS----------SGSSPPGSLPSARPLSLDAAEPAPPPQPAPPP-------- 302

  Fly   295 VPFLHYATGANVAGLPASGIPNSPTTYELAISHPLFMMAA---------PIANMHNIYYNNVTLV 350
                |::.|.:|..:..| :..||......:...|...||         |:|         :...
Mouse   303 ----HHSQGFSVDNIMTS-LRGSPQGSAAELGSGLLASAAASSRAGIAPPLA---------LGAY 353

  Fly   351 APAQQ--YRSP 359
            :|.|.  |.||
Mouse   354 SPGQSSLYSSP 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd96Ca	NP_001287516.1	FH	13..101	CDD:214627	54/87 (62%)
Foxc1	NP_032618.2	Required for transcriptional activation. /evidence=ECO:0000250\|UniProtKB:Q12948	1..51		4/10 (40%)
		FH	78..166	CDD:214627	54/87 (62%)
		Nuclear localization signal 1 (NLS 1). /evidence=ECO:0000250\|UniProtKB:Q12948	78..93		11/14 (79%)
		Nuclear localization signal 2 (NLS 2). /evidence=ECO:0000250\|UniProtKB:Q12948	168..176		6/7 (86%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	173..326		42/219 (19%)
		Required for transcriptional inhibition. /evidence=ECO:0000250\|UniProtKB:Q12948	217..366		38/193 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..393		4/9 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	420..466
		Required for transcriptional activation. /evidence=ECO:0000250\|UniProtKB:Q12948	466..553
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910