Protein Alignment AFDN and SEC3

DIOPT Version :9

• Sequence 1: XP_016866367.1
• Gene: AFDN / 4301
• HGNCID: 7137
• Length: 1832
• Species: Homo sapiens
• Sequence 2: NP_010924.1
• Gene: SEC3 / 856726
• SGDID: S000000810
• Length: 1336
• Species: Saccharomyces cerevisiae
• Alignment Length: 726
• Identity: 151/726 - (20%)
• Similarity: 251/726 - (34%)
• Gaps: 234/726 - (32%)

Human  1151 SPQLPWAEYSEPKKLPGDD-------RLMKNRADHRSSPNV------ANQPPSPGGKSAYASGTT 1202
            |.:.|:...|..::...|:       |.:...:.|.|. ||      ::.||..||..::....:
Yeast     3 SSKSPFKRKSHSRETSHDENTSFFHKRTISGSSAHHSR-NVSQGAVPSSAPPVSGGNYSHKRNVS 66

Human  1203 AKITSVSTGNLCTEEQTPPPRPEAYPIPTQTYTRE-------YFTFPASKSQDRMAPPQN----- 1255
            ....|..|.|...|:                |.|:       .|:.|..|:.:   ||.|
Yeast    67 RASNSSQTSNFLAEQ----------------YERDRKAIINCCFSRPDHKTGE---PPNNYITHV 112

Human  1256 ------QWPNYEEKPHMHTDSNHSSIAIQRVTRSQEELREDKAYQLERHRIEAAMDRKSDSDMWI 1314
                  ::|:....|....::....:.|.....:..:|     .|:.:.|      ..||....|
Yeast   113 RIIEDSKFPSSRPPPDSKLENKKKRLLILSAKPNNAKL-----IQIHKAR------ENSDGSFQI 166

Human  1315 NQSSSLDSSTSSQEHLNHSSKSVTPASTLTKSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPP 1379
            .::..|......::.|     .::....||.|....|:|.:|...| |.:...|..
Yeast   167 GRTWQLTELVRVEKDL-----EISEGFILTMSKKYYWETNSAKERT-VFIKSLITL--------- 216

Human  1380 PVHYAGDFDG-----MSMDLPLPPPPSANQIGLPSAQVAAAERRKREEHQRWYEKEKARLEEERE 1439
               |...|:|     ::.||.|                             :|       .:||.
Yeast   217 ---YIQTFEGHVPELVNWDLSL-----------------------------FY-------LDERS 242

Human  1440 RKRREQERKLGQM-------------RTQSLNPAPFSPLTAQQMKPEKPSTLQRPQETVIRELQP 1491
            .:|.....:.|.:             .|||:...|||..|.:..:.|..|            :.|
Yeast   243 YQRAVITNRPGSVSPIKSPTSNFTTNTTQSVGSVPFSAPTERTRRSETES------------VNP 295

Human  1492 QQQPRTIERRDLQYITVSKEELSSGDSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPD 1556
            ...|.::|.. ....:::|...||..:|:    :.:.:.:||:|||
Yeast   296 VSTPASVEYH-AGMKSLNKAPYSSNSTLN----EVNKRYELEQQQQ------------------- 336

Human  1557 RSAEESDRLRKLMLEWQFQKRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERRARLQDEERRRQ 1621
               :|...||:|    :.|||||..|:.:                |:|||.||  |::.|||:||
Yeast   337 ---QEEAELRRL----EEQKRLQLQKENE----------------MKRLEEER--RIKQEERKRQ 376

Human  1622 QQLEEMRKREAEDRARQEE-ERRRQEEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAARRLLE 1685
            .:||..|:.|.|:|.||.| |.::|.|.:.:|..||::|.:: ....||.:|:::..|.|.||.:
Yeast   377 MELEHQRQLEEEERKRQMELEAKKQMELKRQRQFEEEQRLKK-ERELLEIQRKQREQETAERLKK 440

Human  1686 PEAPGLCRPPLPRDYEPPSPSPAPGAPPPPPQR----NASYLKTQVLS--PDSLFTAKFVAYNEE 1744
            .|...|.:    ::.|..|            :|    |.||  ||.::  .|:|.........||
Yeast   441 EEQEALAK----KEEEEKS------------KRNKVDNESY--TQEINGKVDNLLEDLNAVLAEE 487

Human  1745 EEEEDCSLAGPNSYPGSTGAAVGAHDACRDAKEKRSKSQDADSPGSSGAPENLTFKER------Q 1803
            .|.......|......||..   |||..:    |.......:|.|.|...::::..:.      .
Yeast   488 TETTPTMQNGTYVPERSTAR---AHDQLK----KPLNIAKVESLGGSDLNDSISLSDEIAGLNTS 545

Human  1804 RLFSQGQDVSN 1814
            .|..:.||..|
Yeast   546 NLSGEDQDEKN 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AFDN	XP_016866367.1	None
SEC3	NP_010924.1	PH_Sec3	82..232	CDD:270125	31/181 (17%)
		PTZ00121	<283..478	CDD:173412	71/274 (26%)
		SMC_N	<348..629	CDD:308206	70/253 (28%)
		ARGLU	<358..444	CDD:405931	36/104 (35%)
		Sec3_C	640..1316	CDD:418729

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2286
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030