Protein Alignment AFDN and YPR089W

DIOPT Version :10

• Sequence 1: XP_047274744.1
• Gene: AFDN / 4301
• HGNCID: 7137
• Length: 1909
• Species: Homo sapiens
• Sequence 2: NP_015414.2
• Gene: YPR089W / 856204
• SGDID: S000006293
• Length: 888
• Species: Saccharomyces cerevisiae
• Alignment Length: 1202
• Identity: 210/1202 - (17%)
• Similarity: 356/1202 - (29%)
• Gaps: 455/1202 - (37%)

Human   173 REKEALRQAS----DKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEK 233
            :||.||.:::    |::|||.....|:..:|..:..::...|:|                   ::
Yeast    25 QEKLALVKSTLFKLDQEDRPECDSWVQLVKLICDEDREEEFTTF-------------------KE 70

Human   234 RMQEFRSSDGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCI 298
            .::|.::.:.:..:|..|..|              :...|.||:  .|.|
Yeast    71 LLREVKNVNDKSVTGVALIHY--------------IIVFDRADY--IELL--------------- 104

Human   299 ARVMLPPGAQHSDEKGAK-EIILDDD----------------ECPLQIFREWPSDKGILVFQLKR 346
                      |.:..||| ::.|.||                .|.|::|..:..    :.|.:..
Yeast   105 ----------HDNPSGAKLDLNLVDDIVGYTPLMWSFSLQRRNCCLELFNAFDE----INFNMTN 155

Human   347 RPP----DHIPKKTKKHLEGKTPKGKERADGSGYGSTLPPEKLPYLVELSPGRRNHFAYYN--YH 405
            :..    |.:|                           |...|...:|    :.|.|.|..  .|
Yeast   156 KAGLTAWDMVP---------------------------PYSPLSEFLE----QNNMFRYRTEVKH 189

Human   406 TYEDGSDSRDKPKLYRLQLSVTEVGTEKLDDNSIQLFGPGIQPHHCD----------LTNMDGVV 460
            .....|..:|...|...:.|.|:   |..|:..:|:.|..:.|...|          :.:..|..
Yeast   190 EIPQISQPKDTSLLMSNEDSTTK---ETFDNIDLQVAGLTLSPGANDNMFLDSDEKNMNHSQGAA 251

Human   461 T-VTPRSMDAETYVEGQRISETTMLQSGMKVQFGASHVFKFVDPSQDHALAKRSVD----GGLMV 520
            | :.|      ||.|...                  ..|.:...|.|..|.....|    ..|::
Yeast   252 TLIDP------TYTEDYH------------------GTFDYDKLSPDQYLEFSDFDIPQILNLLI 292

Human   521 KGPRHKPGIVQETTFDLG--------GDIHSGTALPTSKSTTRLDSDRV-SSASSTAERGMVKPM 576
            ..|:.:|.:   ||:..|        .| |...:.|..:|...|...:: :|.||....|:|
Yeast   293 SLPQKEPHM---TTYPAGLIYQCIRYAD-HKIKSKPLVESLINLSLTKILTSVSSNGAAGLV--- 350

Human   577 IRVEQQPDYRRQESRTQDASGPELILP-------ASIEFRESSEDSF-------LSAIINYTNS- 626
                         |........:::|.       :.:.:....:|||       |..:||..:|
Yeast   351 -------------STEASLQAGDIVLQSYWLSCLSFLYYYLCRDDSFFKRHPSVLQELINTIHSI 402

Human   627 -----STVHFKL----SPTYVLYMACRYVLSNQYRPD--ISPTERTHKVIAVVNKMVSMMEGVIQ 680
                 |::|.:|    ..|.:.|...:.|....|:.|  .....:..|::........:.|...:
Yeast   403 IIELTSSIHCRLISLIDSTLLAYTTIQDVKQTLYKRDWNFFKKRKQAKLLLKEKNRKQLKEQQKK 467

Human   681 EVDQVDQKQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVLAHLVQMAFKYLVHCLQSE 745
            |:.:..|.|:|..........|.|:.......|.:.|......:::|.||
Yeast   468 ELHRKSQGQENHEEEEGQQDGNDSDDRASTNDDNNSSVSLFYDKEILRHL--------------- 517

Human   746 LNNYMPAFLDDPEENSLQRP-KIDDVLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINM-W--- 805
               |.|:|    ||.....| ||..:.    ||:|.:    :|...|..:|.|....|:: |
Yeast   518 ---YPPSF----EEQMKPSPLKIVQIF----GALSYV----LNLHQTHPIFQQQCLSISVNWFAT 567

Human   806 -LFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQATTLLTMDKYAPD 869
             |||:::.|......|......||..|..:|:|.:
Yeast   568 TLFNKILKDKKKRSLSRAHAIQIRLNLSTLESWIQ------------------------------ 602

Human   870 DIPNINSTCFKLNSLQLQALLQNYHCAPDEPFI--------PTDLIENVVTVAENTADELARSDG 926
                                 .|..|.|....|        |..||.:|
Yeast   603 ---------------------NNDFCVPKPMLIDDFMWQRFPMTLIRDV---------------- 630

Human   927 REVQLEEDPDLQ-LPFLLPEDGYSCDVVRNIPNGL----------QEFLDPLCQRGFCRLIPHTR 980
            .|:.| .||.|: :....|.|..:.|::.:..|.|          |..|:|:.|     |:
Yeast   631 GEIDL-SDPILRNVATYKPIDENNKDLIYDTSNSLFYYQPFHKIAQIHLEPVFQ-----LL---- 685

Human   981 SPGTWTIYFEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIYV 1045
               .|.......|.|..|:.....|.   |..|..:..:::|.|     ....:.....||..::
Yeast   686 ---QWLQVATTLDSEESLISTMNLLP---RITPVQLLKSMEKYN-----YELNENKFNSKLKKFL 739

Human  1046 KSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATL 1110
            .:.:|      |.:::..|..|           ||                        |.:..|
Yeast   740 NNKIK------DSKMSKADAYL-----------QE------------------------HEIPYL 763

Human  1111 LNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNGSPESPQLPWAEYSEPKKLPGDDRLMKNR 1175
            :   .|.:..::|....|   |.|..|:             |.||.:...:..::  .|...|.|
Yeast   764 V---LPTIPEMTDLYSKG---PDSHSFQ-------------PFLPGSIQDDVYEI--HDVNFKQR 807

Human  1176 ADHRSSPNVANQPPSPGGKSAYASGTT--------AKITSVSTGNLCTEEQTPPPRPEAYPIPTQ 1232
               ::.|.:          |...|||:        |:..:...|......:|..|...|:.:...
Yeast   808 ---QNEPQI----------SRTNSGTSDFTGDEDKAQYETEGVGESIDINETVEPESNAFNVGND 859

Human  1233 TYTREYFTFPASKSQ-------DRMAPPQNQW 1257
            .|.:| ...|:|.:|       |.|  .||.|
Yeast   860 DYFKE-LNIPSSTAQRPAWSNNDDM--EQNPW 888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AFDN	XP_047274744.1	RA1_Afadin	20..132	CDD:340480
		RA2_Afadin	248..348	CDD:340479	19/116 (16%)
		FHA_AFDN	385..503	CDD:438763	24/130 (18%)
		Myo5p-like_CBD_afadin	612..940	CDD:271255	68/361 (19%)
		PDZ_AFDN-like	1013..1100	CDD:467251	11/86 (13%)
		DUF4670	<1470..1688	CDD:464815
YPR089W	NP_015414.2	Ank_2	67..152	CDD:463710	20/148 (14%)
		Myo5p-like_CBD_DIL_ANK	275..776	CDD:271257	119/682 (17%)