Protein Alignment AFDN and SPOM_SPAC25B8.08

DIOPT Version :10

• Sequence 1: XP_047274744.1
• Gene: AFDN / 4301
• HGNCID: 7137
• Length: 1909
• Species: Homo sapiens
• Sequence 2: NP_594468.2
• Gene: SPOM_SPAC25B8.08 / 2542659
• PomBaseID: SPAC25B8.08
• Length: 573
• Species: Schizosaccharomyces pombe
• Alignment Length: 516
• Identity: 108/516 - (20%)
• Similarity: 184/516 - (35%)
• Gaps: 128/516 - (24%)

Human   608 FRESSEDSFLSAIINYTNSSTVHFKLSPTYVLYMACRYVLSNQYRPDISPTERTHKVIAVVNKMV 672
            |.|...||.|...:....:.....:|:|:.:.|:|.|:...  |.|       ..|.:..|
pombe   126 FDEREIDSMLQLFVRDFRADKPALRLAPSKLFYLASRFAFF--YMP-------KEKELGTV---- 177

Human   673 SMMEGVIQEVDQVDQKQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVLAHLV------ 731
             ::...:.||:||.|:..|.......|:||.|.||.::|:|..|..:|:|.|:..:.|:
pombe   178 -LLNAFLCEVNQVTQQHPNDMVLCVQWLANVSLLLFYLKKDNKLDDLTVDIQNRCSELMNSLYIT 241

Human   732 --QMAFKYLVHCLQSELNNY-----MPAFLDDPEENSLQRPKIDD---------------VLHTL 774
              |.|.:.:...|:..:..|     :...|.....|.|:|...:|               :...:
pombe   242 ICQDAMRRMNENLEEGMVKYTGIQGLEDILRSRSWNLLRRRPTNDASTSPRSTPSASPRSITKII 306

Human   775 TGAMSLLRRCRVNAALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAE 839
            ...:.||....::..:..|...|||.::...|||.:::  :....|.......|..:..:|.|::
pombe   307 ASTLHLLEVFYIHPLIRAQCIEQLFSWLGARLFNIVIS--NKKYLSRAAAMETRFNISSLEEWSQ 369

Human   840 KQGLELAADCHLSRIVQATTLLTMDKYAPDDIPNINSTCFKLNSLQLQALLQ-NYHCAPDEPFIP 903
            ....:|......                ||:...::.....|:.:||...|| .|..:.||.  |
pombe   370 TNSPKLQKPFDY----------------PDEDLKVDLISKLLSLVQLLQWLQCLYRLSEDED--P 416

Human   904 TDLIENVVTV-AEN-----TADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQE 962
            ..|.|.:.:: |.|     ||.:|.|.|..|.::.:      .||...|.:..:.:|...|.
pombe   417 RALQETLESLDALNPRQIYTAAKLYRPDITETKVSK------TFLKKLDAFHEEKLREKINS--- 472

Human   963 FLDPLCQRGFCRLIPHTRSPGTWTIYFEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMG 1027
                 ..:|                   ...||..||::.| :..||:       :..|.|....
pombe   473 -----SDKG-------------------DVSYEFELLKDET-VFSPLK-------LPTKAQLINA 505

Human  1028 LS-IVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMT 1087
            .| ||:..|..:|:..::...|..                :.:|.....|||.|| |||.|
pombe   506 YSYIVSGNGFNEDRKIVFQPHVSN----------------ILIDKLEENGLSMER-AELPT 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AFDN	XP_047274744.1	RA1_Afadin	20..132	CDD:340480
		RA2_Afadin	248..348	CDD:340479
		FHA_AFDN	385..503	CDD:438763
		Myo5p-like_CBD_afadin	612..940	CDD:271255	75/362 (21%)
		PDZ_AFDN-like	1013..1100	CDD:467251	18/76 (24%)
		DUF4670	<1470..1688	CDD:464815
SPOM_SPAC25B8.08	NP_594468.2	Myo5p-like_CBD_DIL_ANK	123..507	CDD:271257	92/455 (20%)