Protein Alignment AFDN and afdn

DIOPT Version :10

• Sequence 1: XP_047274744.1
• Gene: AFDN / 4301
• HGNCID: 7137
• Length: 1909
• Species: Homo sapiens
• Sequence 2: XP_031758152.1
• Gene: afdn / 100493083
• XenbaseID: XB-GENE-948333
• Length: 1902
• Species: Xenopus tropicalis
• Alignment Length: 1938
• Identity: 1474/1938 - (76%)
• Similarity: 1650/1938 - (85%)
• Gaps: 68/1938 - (3%)

Human     3 AGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCIRVSSTAT 67
            :|.|:||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||
 Frog     2 SGSREEERRKLADIINHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCIRVSSTAT 66

Human    68 TQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGEERRLDIDEKPLVVQLNWNKDDREGRFVLKNE 132
            ||||||||||||||||||||||:|||||||||||||:||.:||||||||||||||||||||||||
 Frog    67 TQDVIETLAEKFRPDMRMLSSPRYSLYEVHVSGEERKLDFEEKPLVVQLNWNKDDREGRFVLKNE 131

Human   133 NDAIPPKKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQASDKDDRPFQGEDVENS 197
            ||..|.|||||||||||||||||||||||||||||||||:||::.|:|::|.:|||...:|.||.
 Frog   132 NDIFPAKKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKRRERDILKQSTDNEDRPQVRDDSENL 196

Human   198 RLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSSDGRPDSGGTLRIYADSLKPNI 262
            :||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   197 QLAMEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSSDGRPDSGGTLRIYADSLKPNI 261

Human   263 PYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIARVMLPPGAQHSDEKGAKEIILDDDECPL 327
            |||||||||.|.|||||.|||||||:||||||:||||:|:||||||||| ||.||.||||:||||
 Frog   262 PYKTILLSTNDTADFAVIEALEKYGMEKENPKEYCIAKVVLPPGAQHSD-KGMKEFILDDEECPL 325

Human   328 QIFREWPSDKGILVFQLKRRPPDHIPKKTKKHLEGKTPKGKERADGSGYGSTLPPEKLPYLVELS 392
            .|||:|||:||.|||||||||.|.:.|:.:|| |.|:.|.|||  |..|..:|.|:|||||||||
 Frog   326 HIFRDWPSEKGELVFQLKRRPTDSLLKQNRKH-ESKSGKSKER--GDHYSLSLSPDKLPYLVELS 387

Human   393 PGRRNHFAYYNYHTYEDGSDSRDKPKLYRLQLSVTEVGTEKLDDNSIQLFGPGIQPHHCDLTNMD 457
                           .|||||||||||||||.|||||||||..||||||||||||.|||||.|||
 Frog   388 ---------------ADGSDSRDKPKLYRLQPSVTEVGTEKFQDNSIQLFGPGIQHHHCDLNNMD 437

Human   458 GVVTVTPRSMDAETYVEGQRISETTMLQSGMKVQFGASHVFKFVDPSQDHALAKRSVDGGLMVKG 522
            |||||||||:||:|||:|.||||||||.||:.||||:|||||||||:.||.|.||..|.|.:.|.
 Frog   438 GVVTVTPRSIDADTYVDGHRISETTMLHSGVTVQFGSSHVFKFVDPNLDHLLGKRLSDAGQIGKN 502

Human   523 PRHKPGIVQETTFDLGGDIHSGTALPTSKSTTRLDSDRVSSASSTAERGMVKPMIRVEQQPDYRR 587
            .|.|.|: |||||.|.|::.....||.:|..::||:||....:   |||||||:||:::|.|.|.
 Frog   503 QRSKQGL-QETTFGLEGEVLGDVTLPVNKMVSKLDNDRTPGMT---ERGMVKPIIRMDKQQDQRV 563

Human   588 QESRTQDASGPELILPASIEFRESSEDSFLSAIINYTNSSTVHFKLSPTYVLYMACRYVLSNQYR 652
            |..|:||:.|||.:|||:|||||:|||:||||||||||||||||||||||||||.|||||||:||
 Frog   564 QNGRSQDSQGPENVLPANIEFRENSEDAFLSAIINYTNSSTVHFKLSPTYVLYMTCRYVLSNKYR 628

Human   653 PDISPTERTHKVIAVVNKMVSMMEGVIQEVDQVDQKQKNIAGALAFWMANASELLNFIKQDRDLS 717
            ||.||.||||||||||||||.|||.||||:|:.:||||||||||||||||||||||||||||||:
 Frog   629 PDTSPAERTHKVIAVVNKMVGMMESVIQEIDKGNQKQKNIAGALAFWMANASELLNFIKQDRDLN 693

Human   718 RITLDAQDVLAHLVQMAFKYLVHCLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLR 782
            |||||||||||||||||||||||||||||.:.||||:||||||..|||||:||||||||||||||
 Frog   694 RITLDAQDVLAHLVQMAFKYLVHCLQSELTSSMPAFIDDPEENDSQRPKIEDVLHTLTGAMSLLR 758

Human   783 RCRVNAALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAA 847
            |||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||
 Frog   759 RCRVNAALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLAHIEAWAEKQGLELAA 823

Human   848 DCHLSRIVQATTLLTMDKYAPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIENVVT 912
            |||||||||||||||||||:..||||||:||||||||||||||||||||||||:|||:||::||:
 Frog   824 DCHLSRIVQATTLLTMDKYSHQDIPNINNTCFKLNSLQLQALLQNYHCAPDEPYIPTELIDSVVS 888

Human   913 VAENTADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLCQRGFCRLIP 977
            ||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||:|
 Frog   889 VAENTADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLEPLCQRGFCRLVP 953

Human   978 HTRSPGTWTIYFEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMGLSIVAAKGAGQDKLG 1042
            |:||||.||||||||::|::||.:||:|  |||||||||||||||||||||||||||||||:|||
 Frog   954 HSRSPGMWTIYFEGAEFENNLLTDNTDL--PLRKEPEIITVTLKKQNGMGLSIVAAKGAGQEKLG 1016

Human  1043 IYVKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGL 1107
            ||:|||||||||:|||||||||||:||||:|||||||||||||||||.:||||||||||||||||
 Frog  1017 IYIKSVVKGGAAEVDGRLAAGDQLISVDGQSLVGLSQERAAELMTRTGAVVTLEVAKQGAIYHGL 1081

Human  1108 ATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNGSPESPQLPWAEYSEPKKLPGDDRLM 1172
            |||||||||:|||  ||||||||||||||||||||::|||||:|||..|.||:|||||||||:||
 Frog  1082 ATLLNQPSPLMQR--DRRGSGKPRPKSEGFELYNNASQNGSPDSPQTQWPEYTEPKKLPGDDKLM 1144

Human  1173 KNRADHRSSPNVANQPPSPGGKSAYASGTTAKITSVSTGNLCTEEQTPPPRPEAYPIPTQTYTRE 1237
            ||||||||||||||||.|||||:.|:|.:|.||||||||||||||||.|.||||||||||||.||
 Frog  1145 KNRADHRSSPNVANQPQSPGGKTTYSSSSTVKITSVSTGNLCTEEQTAPARPEAYPIPTQTYARE 1209

Human  1238 YFTFPASKSQDRMAPPQNQWPNYEEKPHMHTDSNHS-SIAIQRVTRSQEELREDKAYQLERHRIE 1301
            |||||..|||||:.|.||||..||:...:...:||: :.:.|:|..|:||||::..:|.||.|:|
 Frog  1210 YFTFPTPKSQDRIGPAQNQWQGYEDNFQVQMGNNHARNTSAQQVAYSEEELRDNLTFQSERGRVE 1274

Human  1302 AA----MDRKSDSDMWINQSSSLDSSTSSQEHLNHSSKSVTPASTLTKSGPGRWKTPAAIPATPV 1362
            ..    ::....:|.|.|:.||::||.|.|:..|..:.||   .:|:|:||||||||.:..:..|
 Frog  1275 PQVRKDVEHLDGNDTWFNRGSSMESSASCQDLNNSKTHSV---GSLSKTGPGRWKTPISSQSATV 1336

Human  1363 AVSQPIRTDLPPPPPPPPVHYAGDFDGMSMDLPLPPPPSANQIGL-PSAQVAAAERRKREEHQRW 1426
            .:.||:|||| ||||||||||..:|:|:.:|||||||||.:|:|| .::|.||.||:||||||||
 Frog  1337 LLPQPVRTDL-PPPPPPPVHYGAEFEGVPIDLPLPPPPSESQLGLSTNSQAAALERKKREEHQRW 1400

Human  1427 YEKEKARLEEERERKRREQERKLGQMRTQ--SLNPAPFSPLT--------AQQMKPEKPSTLQRP 1481
            |||||||||||||||||||||||||:|.|  ::.|.|.:|.:        ..|.:.|||:||.|.
 Frog  1401 YEKEKARLEEERERKRREQERKLGQVRPQPPTIPPQPVNPQSPPLIPPPNVAQARTEKPATLPRQ 1465

Human  1482 QETVIRELQPQQQPRTIERRDLQYITVSKEELSSGDSLSPDPWKRDAKEKLEKQQQMHIVDMLSK 1546
            ||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||
 Frog  1466 QETVIRELQPQQQPRTIERRDLQYITVSKEELSSSDSLSPDPWKRDAKEKLEKQQQMHIVDMLSK 1530

Human  1547 EIQELQSKPDRSAEESDRLRKLMLEWQFQKRLQESKQK--DEDDEEEEDDDVDTMLIMQRLEAER 1609
            ||.|||:||||::||:|||||||||||||||||||:||  |:||::::|||||||||||||||||
 Frog  1531 EINELQNKPDRTSEENDRLRKLMLEWQFQKRLQESQQKDDDDDDDDDDDDDVDTMLIMQRLEAER 1595

Human  1610 RAR------------LQDEERRRQQQLEEMRKREAEDRARQEEERRRQEEERTKRDAEEKRRQEE 1662
            :||            ||||||||||.|||.||||||||.|||||.|.|||||.:|:|||||||||
 Frog  1596 KARQTAMPAISILDLLQDEERRRQQHLEEARKREAEDRLRQEEEHRHQEEERARREAEEKRRQEE 1660

Human  1663 GYYSRLEAERRRQHDEAARRLLEPEAPGLCRPPLPRDYEPPSPSPAPGAPPPPPQRNASYLKTQV 1727
            .||:||||||||.|:||.||||:||.|||.||||||:||..||:..|..||||||||.||||||.
 Frog  1661 EYYNRLEAERRRIHEEAERRLLDPEEPGLYRPPLPREYELSSPTLPPNPPPPPPQRNTSYLKTQA 1725

Human  1728 LSPDSLFTAKFVAYNEEEEEEDCSLAGQDKYSSTRKSHGDLLPAPLKPRPPPCQ-PRPASDGVFL 1791
            ||||:::|||||.|.  ::|||.:|:|||||||.|||:|||.||..||:.|..: |||.|||:||
 Frog  1726 LSPDTVYTAKFVTYT--DDEEDTNLSGQDKYSSMRKSYGDLPPAAHKPQLPAARLPRPVSDGIFL 1788

Human  1792 SNSFQPPSAKANSTAHKKGQPLPPPKKSSSYHPSHCKGRGPNSYPGSTGAAVGAHDACRDAKEKR 1856
            |.|||||||.|||||.|.|.|:  ..|.|..|.|..|  |||||.||:||||..::..:|.::.|
 Frog  1789 SGSFQPPSANANSTASKTGPPI--ANKPSFLHYSSSK--GPNSYSGSSGAAVPGNEVYKDPRDVR 1849

Human  1857 SKSQDADSPGSSGAPENLTFKERQRLFSQGQDVSNKVKASRKLTELENELNTK 1909
            .||||.::..:.||||:||||||||||||||||||||||||||.|||||||||
 Frog  1850 LKSQDGEAYSTGGAPESLTFKERQRLFSQGQDVSNKVKASRKLMELENELNTK 1902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AFDN	XP_047274744.1	RA1_Afadin	20..132	CDD:340480	107/111 (96%)
		RA2_Afadin	248..348	CDD:340479	84/99 (85%)
		FHA_AFDN	385..503	CDD:438763	88/117 (75%)
		Myo5p-like_CBD_afadin	612..940	CDD:271255	298/327 (91%)
		PDZ_AFDN-like	1013..1100	CDD:467251	79/86 (92%)
		DUF4670	<1470..1688	CDD:464815	184/231 (80%)
afdn	XP_031758152.1	RA1_Afadin	19..131	CDD:340480	107/111 (96%)
		RA2_Afadin	247..346	CDD:340479	84/99 (85%)
		FHA_AFDN	380..483	CDD:438763	88/117 (75%)
		Myo5p-like_CBD_afadin	587..916	CDD:271255	298/328 (91%)
		PDZ_AFDN-like	987..1074	CDD:467251	79/86 (92%)