Protein Alignment shams and LARGE1

DIOPT Version :10

• Sequence 1: NP_001097911.1
• Gene: shams / 43008
• FlyBaseID: FBgn0039273
• Length: 362
• Species: Drosophila melanogaster
• Sequence 2: NP_004728.1
• Gene: LARGE1 / 9215
• HGNCID: 6511
• Length: 756
• Species: Homo sapiens
• Alignment Length: 284
• Identity: 77/284 - (27%)
• Similarity: 131/284 - (46%)
• Gaps: 34/284 - (11%)

  Fly    29 TEN-KGKMLGYNELQTGKPP-------LYIVVVSCGQRVQETLVMIKSAILFNYDEEYLKFVIFT 85
            :|| :..::..|..:.|:.|       :::.:|..|......:|.:..::|| :....|.|.:..
Human   111 SENLRAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLF-HRRNPLHFHLIA 174

  Fly    86 EDGKGDEFREKLTDWRDIKPFTFDF-EILPLKFPSGNEVEW---RNLFKPCAAQRLFLPSLL-TH 145
             |...::....|.....:.....|| ....||    :||.|   ::........:|.|...| .:
Human   175 -DSIAEQILATLFQTWMVPAVRVDFYNADELK----SEVSWIPNKHYSGIYGLMKLVLTKTLPAN 234

  Fly   146 VDSLLYVDTDILFLSPISDIWRFFKKFNETQMSALTPEHENENIGWY--NRFARH---PFYGRLG 205
            ::.::.:||||.|.:.|:::|..|.||...|:..|.   ||:: .||  |.:..|   |..|| |
Human   235 LERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLV---ENQS-DWYLGNLWKNHRPWPALGR-G 294

  Fly   206 VNSGVMLMNLTRMREMKWEQ-HIVSIHKEY--KLRIIWGDQDIINILFYYHPDKLYIMPCEYNYR 267
            .|:||:|:.|.::|:||||| ..::..:|.  .|.....||||.|.:...:|..:|.:||.:|.:
Human   295 YNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQ 359

  Fly   268 -PDHCMYMSICNMSQTGVKVIHGN 290
             .||.. ...|....:.:||||.|
Human   360 LSDHTR-SEQCYRDVSDLKVIHWN 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shams	NP_001097911.1	Glyco_tranf_GTA_type	48..343	CDD:472172	72/257 (28%)
LARGE1	NP_004728.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	43..69
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	81..109
		GT8_LARGE_C	138..417	CDD:133053	72/257 (28%)
		Xylosyltransferase activity. /evidence=ECO:0000305|PubMed:22223806	138..413		72/257 (28%)
		Glucuronyltransferase activity. /evidence=ECO:0000305|PubMed:22223806	414..756
		Glyco_transf_49	473..743	CDD:464027