DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shams and Large2

DIOPT Version :9

Sequence 1:	NP_001097911.1	Gene:	shams / 43008	FlyBaseID:	FBgn0039273	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	XP_006499317.1	Gene:	Large2 / 228366	MGIID:	2443769	Length:	715	Species:	Mus musculus

Alignment Length:	382	Identity:	93/382 - (24%)
Similarity:	151/382 - (39%)	Gaps:	101/382 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLCLIALAILSYFVH------QRPSWVTEN-----------------------------KGKMLG 37
            :|.|:.|.::.:|:.      :|.||..|.                             :.:.|.
Mouse    14 VLLLLLLLVVGFFLFGRDPDCKRRSWAGEEGTLCDRCLLTPRVFSDGLGTTATLDEDPYRSRNLS 78

  Fly    38 YNELQTGKPP----LYIVVVSCGQRVQETLVMIKSAILFNYDEEYLKFVIFTEDGKGDEFREKL- 97
            .:..|...||    |::.:|..|......::.:..::|| |.:..|...:.| |.......|.|
Mouse    79 ASSPQLLLPPKCEMLHVAIVCAGYNSSREIITLTKSLLF-YRKNPLHLHLIT-DAVARNILETLF 141

  Fly    98 ------------TDWRDIKPFTFDFEILPLKFPSGNEVEWRNLFKPCAAQRLFLPSLL-THVDSL 149
                        .|..::||..   ..:|.|..||       |:   ...:|.|||:| ..:..:
Mouse   142 RTWMVPAVVVSFYDAEELKPLV---SWIPNKHYSG-------LY---GLMKLVLPSILPPSLARV 193

  Fly   150 LYVDTDILFLSPISDIWRFFKKFNETQMSALTPEHENENIGWY--NRFARH---PFYGRLGVNSG 209
            :.:|||:.|.|.|.::|..|..|::.|:..|.   ||:: .||  |.:..|   |..|| |.|:|
Mouse   194 IVLDTDVTFSSDIVELWALFDHFSDKQVVGLV---ENQS-DWYLGNLWKNHRPWPALGR-GFNTG 253

  Fly   210 VMLMNLTRMREMKWEQHIVSIHKEYKLRII---WGDQDIINILFYYHPDKLYIMPCEYNYR-PDH 270
            |:|:.|.|:::..|||......|...|.::   ..||||.|.:...||..::.:||.:|.: .||
Mouse   254 VILLWLDRLQQTGWEQMWKVTAKRELLTLMATSLADQDIFNAVIKEHPHLVHPLPCVWNVQLSDH 318

  Fly   271 CMYMSICNMSQTGVKVIHGNRGYFHSDRQPLFKSIYGAMENYQLGSNANTEFLMPLH 327
            .. ...|.:....:||||.|     |.::...|             |.:.||...||
Mouse   319 TR-AERCYLEAADLKVIHWN-----SPKKLRVK-------------NKHAEFFRNLH 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shams	NP_001097911.1	Glyco_tranf_GTA_type	48..343	CDD:299700	81/303 (27%)
shams	NP_001097911.1	RfaJ	64..>270	CDD:224359	63/228 (28%)
Large2	XP_006499317.1	GT8_LARGE_C	93..372	CDD:133053	81/303 (27%)
Large2	XP_006499317.1	Glyco_transf_49	427..660	CDD:372794
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836166
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3765
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740